N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
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- CAS-Nr.
- 302964-08-5
- Englisch Name:
- N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
- Synonyma:
- Dasatinib Int N-1;CAY10697;2-((6-ChL;)amino)-N-(2-chL;dasatinib Dichloro;Dasatinib Impurity M;Dasatinib EP Impurity-D;Dasatinib Intermediate 1;Dasatinib Dichloro Impurity;2-(6-Chloro-2-MethylpyriMidin-4-ylaMino)-N-(2-chloro-6-Methyl
- CBNumber:
- CB51473109
- Summenformel:
- C16H13Cl2N5OS
- Molgewicht:
- 394.28
- MOL-Datei:
- 302964-08-5.mol
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N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Eigenschaften
- Schmelzpunkt:
- 333-335°C
- Siedepunkt:
- 566.95° C (Predicted)
- Dichte
- 1.516±0.06 g/cm3(Predicted)
- Brechungsindex
- n20D 1.72 (Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- L?slichkeit
- DMSO (Slightly)
- pka
- 10.92±0.70(Predicted)
- Aggregatzustand
- Solid
- Farbe
- Pale Yellow
- Wasserl?slichkeit
- Slightly soluble in water
- InChI
- InChI=1S/C16H13Cl2N5OS/c1-8-4-3-5-10(17)14(8)23-15(24)11-7-19-16(25-11)22-13-6-12(18)20-9(2)21-13/h3-7H,1-2H3,(H,23,24)(H,19,20,21,22)
- InChIKey
- LMXUWARKUIELGT-UHFFFAOYSA-N
- SMILES
- S1C(C(NC2=C(C)C=CC=C2Cl)=O)=CN=C1NC1C=C(Cl)N=C(C)N=1
- CAS Datenbank
- 302964-08-5(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide is a pharmaceutical intermediate compound used as a synthetic intermediate for dasatinib. Dasatinib is a targeted anticancer drug used to treat chronic myeloid leukaemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukaemia (ALL). It is also a receptor and non-receptor Tyk (tyrosine kinase) inhibitor, which plays an important role in certain cancers and fibrotic diseases.
Chemische Eigenschaften
Pale Yellow Solid
N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 289)Lieferanten
302964-08-5()Verwandte Suche:
- 2-(6-Chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
- 5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-
- Dasatinib Intermediate 1
- 2-(6-Chloro-2-MethylpyriMidin-4-ylaMino)-N-(2-chloro-6-Methyl
- 2-[(6-chloro-2-MethylpyriMidin-4-yl)aMino]-N-(2-chloro-6-Methylphenyl)-1,3-thiazole-5-carboxaMide
- N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-yrimidinyl)amino]-5-thiazolecarboxamide
- N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methylpyrimidin-4-yl)amino]
- CAY10697
- N-(2-Chloro-6-methyl-phenyl)-2-[(6-chloro-2-methyl-pyrimidin-4-yl)amino]thiazole-5-carboxamide
- N-(2-CHLORO-6-METHYLPHENYL)-2-[(6-CHLORO-2-METHYL-4-PYRIMIDINYL)AMINO]-5-THIAZOLECARBOXAMIDE
- 2-[(6-Chloro-2-methyl-4-pyrimidyl)amino]-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
- N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxamide
- Dasatinib Dichloro Impurity
- )amino)-N-(2-chL
- 2-((6-ChL
- N- (2-chloro-6-methylphenyl) -2-[(6-chloro-2-methyl-4-pyrimidinyl) amino] -5-thiazole-formamide
- Dasatinib Impurity M
- N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidi...
- dasatinib Dichloro
- 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide 95%
- Dasatinib Int N-1
- N - (2-chloro-6-methylphenyl) -2- [(6-chloro-2-methyl-4-pyrimidinyl) amino] -5-thiazolamide
- N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)ami]-5-thiazolecarboxamide
- 2-(6-Chloro-2-methyl-pyrimidin-4-ylamino)-thiazole-5-carboxylic acid (2-chloro-6-methyl-phenyl)-amide
- N-(2-Chloro-6-Methylphenyl)-2-[(6-chloro-2-Methyl-4-pyriMidinyl)aMino]-5-thiazolecarboxaMi
- Dasatinib EP Impurity-D
- 302964-08-5
- 2964-08-5
- 964-08-5
- Dasatinib
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Sulfur & Selenium Compounds
