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(4-Amino-N-pyrimidin-2-ylbenzolsulfonamidato-NN,O1)silber

Silver sulfadiazine Struktur
22199-08-2
CAS-Nr.
22199-08-2
Bezeichnung:
(4-Amino-N-pyrimidin-2-ylbenzolsulfonamidato-NN,O1)silber
Englisch Name:
Silver sulfadiazine
Synonyma:
SILVER SULPHADIAZINE;silvadene;SULFADIAZINE SILVER;SILVER(I) SULFADIAZINE;SD-Ag;geben;Dermazin;Nsc625324;dermazine;flamazine
CBNumber:
CB4744940
Summenformel:
C10H9AgN4O2S
Molgewicht:
357.14
MOL-Datei:
22199-08-2.mol

(4-Amino-N-pyrimidin-2-ylbenzolsulfonamidato-NN,O1)silber Eigenschaften

Schmelzpunkt:
285 °C (dec.)(lit.)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
L?slichkeit
DMSO (Slightly, Heated), Methanol (Slightly)
Aggregatzustand
powder
Farbe
White to Off-White
Merck 
14,8903
Stabilit?t:
Stable. Incompatible with strong oxidizing agents.
InChIKey
UEJSSZHHYBHCEL-UHFFFAOYSA-N
CAS Datenbank
22199-08-2(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 26-36
WGK Germany  2
RTECS-Nr. WP1950000
HazardClass  IRRITANT
HS Code  2935904000
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P332+P313 Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P337+P313 Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

(4-Amino-N-pyrimidin-2-ylbenzolsulfonamidato-NN,O1)silber Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

solid

Verwenden

Silver(I) sulfadiazine (AgSD) is popularly used for treating second-degree burn wounds as it acts as an antimicrobial agent and prevents infections. Silver sulfadiazine-impregnated polyurethane (PU) foam, chitosan/chondroitin sulfate films may be used for wound dressing.

Indications

Silver sulfadiazine (Silvadene, SSD) is a synthetic agent that combines the beneficial properties of silver nitrate and sulfonamides. It acts upon the cell membrane and cell wall. It is used primarily as an adjunct in the prevention and treatment of wound sepsis in patients with second- and third-degree burns and for wound care of chronic ulcers. It is bactericidal against many gram-positive and gram-negative bacteria as well as C. albicans and is reasonably effective against P. aeruginosa and S. aureus.
Bacteria susceptible to sulfadiazine but resistant to silver nitrate, as well as those sensitive to silver nitrate but resistant to sulfadiazine, have shown good response to silver sulfadiazine. It does not stain, is unlikely to produce electrolyte imbalance, and does not cause systemic acidosis. Some patients note a stinging sensation on application, and because this compound can be absorbed, systemic sulfonamide reactions similar to those caused by sulfonamides may occur.

Pharmazeutische Anwendungen

Silver sulfadiazine is extremely insoluble. In addition to the usual activity of sulfonamides it exhibits activity – almost certainly attributable to the silver component – against Ps. aeruginosa and some fungi.
It is variably absorbed after topical application depending on the integrity of the skin. Toxic concentrations may be achieved in patients with extensive burns. It is used topically, mainly for burns, pressure sores and leg ulcers. Central venous catheters impregnated with chlorhexidine and silver sulfadiazine have been developed to reduce bacterial colonization. Other suggested uses include the prevention of infection in skin graft donor sites and cord care in newborn infants.

Clinical Use

The silver salt of sulfadiazine applied in a water-misciblecream base has proved to be an effective topical antimicrobialagent, especially against Pseudomonas spp. This is particularlysignificant in burn therapy because pseudomonadsare often responsible for failures in therapy. The salt is onlyslightly soluble and does not penetrate the cell wall butacts on the external cell structure. Studies using radioactivesilver have shown essentially no absorption into body fluids.Sulfadiazine levels in the serum were about 0.5 to2 mg/100 mL.
This preparation is reported to be easier to use thanother standard burn treatments, such as application offreshly prepared dilute silver nitrate solutions or mafenideointment.

(4-Amino-N-pyrimidin-2-ylbenzolsulfonamidato-NN,O1)silber Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


(4-Amino-N-pyrimidin-2-ylbenzolsulfonamidato-NN,O1)silber Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 385)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Wuhan Fortuna Chemical Co., Ltd
+86-027-59207850
info@fortunachem.com China 5986 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5893 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971
deasea125996@gmail.com China 2472 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20288 58
Sigma Audley
+86-15937194204 +86-18126314766
nova@sh-teruiop.com China 493 58
airuikechemical co., ltd.
+undefined86-15315557071
sales02@sdzhonghuimaterial.com China 983 58
Hangzhou Hyper Chemicals Limited
+86-0086-57187702781 +8613675893055
info@hyper-chem.com China 295 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58
Hebei Zhuanglai Chemical Trading Co.,Ltd
+8613343047651
admin@zlchemi.com China 3002 58
Shanghai Bojing Chemical Co.,Ltd.
+86-86-02137122233 +8613795318958
bj1@bj-chem.com China 299 55

22199-08-2((4-Amino-N-pyrimidin-2-ylbenzolsulfonamidato-NN,O1)silber)Verwandte Suche:


  • silver (4-aminophenyl)sulfonyl-pyrimidin-2-yl-azanide
  • SILVER SULFADIAZINE
  • SULPHADIAZINE-AG
  • 4-amino-n-(2-pyrimidinyl)benzenesulfonamidesilversalt
  • 4-amino-n-2-pyrimidinylbenzenesulfonamide monosilver salt
  • (4-amino-N-pyrimidin-2-ylbenzenesulphonamidato-NN,O1)silver
  • [4-Amino-N-(2-pyrimidinyl-kN1)benzenesulfonamidato-kO]silver
  • 4-Amino-N-2-pyrimidinylbenzenesulfonamide Silver Complex
  • Dermazin
  • Flammazine
  • Silver, 4-amino-N-(2-pyrimidinyl-.kappa.N1)benzenesulfonamidato-.kappa.O-
  • SILVERSULFADIAZINE,MICRONIZED
  • SILVERSULFADIAZINE,MICRONIZED,USP
  • sulfadiazine silver,SD-Ag
  • Sulfadiazine,Siliver salt
  • 4-Amino-N-2-pyrimidinylbenzenesulfonamide monosilver(1+) salt
  • Sulfadiazine sailver salt
  • Benzenesulfonamide,4-amino-N-2-pyrimidinyl-, silver complex
  • Nsc625324
  • Silver,(4-amino-N-2-pyrimidinylbenzenesulfonamidato-nn,o1)-
  • Sulfadiazine silversilvadene
  • Silver Sulfdiazine
  • SD-Ag
  • Silver Sulfadiazine (200 mg)
  • 3-(4-aMinophenyl)-3-oxo-1H,4H-2$l^{3},3$l^{6},4,5,9000000$l^{5},1-pyriMido[2,1-d]1$l^{3}-oxa-2$l^{6}-thia-3,5$l^{5}-diaza-6-argentacyclohexan-1-yliuM-4-id-9-yl
  • SILVER(I) SULFADIAZINE 98%
  • Silver suifadiazine
  • Silver,[4-aMino-N-(2-pyriMidinyl-kN1)benzenesulfonaMidato-kO]-
  • 4-amino-n-2-pyrimidinyl-benzenesulfonamidmonosilver(1+)salt
  • dermazine
  • flamazine
  • geben
  • n(sup1)-2-pyrimidinyl-sulfanilamidmonosilver(1+)salt
  • sulfadiazinesilversalt
  • (4-aminophenyl)sulfonyl-pyrimidin-2-ylazanide
  • Sulfadiazine silver Sulfadiazine Silver Salt SD-Ag
  • silver(1+) sulfadiazinate
  • silver 4-amino-N-(2-pyrimidinyl)benzenesulfonamide
  • silver sulfadiazine powder
  • Silver(1+) [(4-aminophenyl)sulfonyl](2-pyrimidinyl)azanide
  • SilverSulfadiazine>
  • Sulfadiazine Silver RS
  • Silver sulfadiazine USP/EP/BP
  • Silver(I) ((4-Aminophenyl)sulfonyl)(pyrimidin-2-yl)amide
  • Silver Sulfadiazine ExiPlus, Multi-Compendial, 98%
  • Silver Sulfadiazine (1612608)
  • SILVER(I) SULFADIAZINE
  • SILVER SULPHADIAZINE
  • SULFADIAZINE SILVER
  • silvadene
  • SILVER SULPHADIAIZINE
  • Silver Sulfadiazine, ≥ 98.0%
  • SuIfadiazine Silver
  • Silvadene|||Dermazin|||Flamazine
  • 22199-08-2
  • 722199-08-2
  • 1715998-31-4
  • C10H9AgN4O2S
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