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Sulfamethoxypyridazin

Sulfamethoxypyridazine Struktur
80-35-3
CAS-Nr.
80-35-3
Bezeichnung:
Sulfamethoxypyridazin
Englisch Name:
Sulfamethoxypyridazine
Synonyma:
Sulphamethoxypyridazine;Sulfamethoxypyridazine-d3;SMPZ;Paramid;Sulfametoxipiridazine;6-Sulfanilamido-3-methoxypyridazine;N1-(6-Methoxy-3-pyridazinyl)sulfanilamide;Durox;Kinex;Kynex
CBNumber:
CB1107025
Summenformel:
C11H12N4O3S
Molgewicht:
280.3
MOL-Datei:
80-35-3.mol

Sulfamethoxypyridazin Eigenschaften

Schmelzpunkt:
182-183°
Siedepunkt:
564.9±60.0 °C(Predicted)
Dichte
1.3936 (rough estimate)
Brechungsindex
1.6200 (estimate)
storage temp. 
2-8°C
L?slichkeit
DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
Crystalline Powder
pka
6.7(at 25℃)
Farbe
White to yellow
Wasserl?slichkeit
579.5mg/L(25 ºC)
Merck 
14,8919
BRN 
277076
CAS Datenbank
80-35-3(CAS DataBase Reference)
NIST chemische Informationen
Pyridazine, sulfamethoxy-(80-35-3)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 37/38-41
S-S?tze: 26-39
WGK Germany  2
RTECS-Nr. WP0400000
10
HS Code  29350090
Toxizit?t LD50 orally in mice: 1750 mg/kg, (Seki)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen. Sensibilisierung der Atemwege Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" /> P261, P285, P304+P341, P342+P311,P501
Sicherheit
P261 Einatmen von Staub vermeiden.
P272 Kontaminierte Arbeitskleidung nicht au?erhalb des Arbeitsplatzes tragen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P284 Atemschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P333+P313 Bei Hautreizung oder -ausschlag: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Sulfamethoxypyridazin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R37/38:Reizt die Atmungsorgane und die Haut.
R41:Gefahr ernster Augensch?den.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S39:Schutzbrille/Gesichtsschutz tragen.

Chemische Eigenschaften

White or slightly yellow crystalline powder; odorless, bitter taste; discolored when exposed to light. The product is slightly soluble in acetone, very slightly soluble in ethanol, almost insoluble in water; easily soluble in dilute hydrochloric acid or alkali hydroxide solution.

Verwenden

Sulfamethoxypyridazine is a long-acting sulfonamide antibiotic with anti-inflammatory and antibacterial effects, mainly used for streptococcus, staphylococcus, Escherichia coli and other infections, especially for urinary tract infections.

Application

Sulfamethoxypyridazine may be used as a reference standard for the determination of sulfamethoxypyridazine in pharmaceutical formulations by liquid chromatography method.

Definition

ChEBI: Sulfamethoxypyridazine is a sulfonamide consisting of pyridazine having a methoxy substituent at the 6-position and a 4-aminobenzenesulfonamido group at the 3-position. It has a role as an antiinfective agent, an EC 2.5.1.15 (dihydropteroate synthase) inhibitor and a drug allergen. It is a member of pyridazines, a sulfonamide and a sulfonamide antibiotic. It derives from a sulfanilamide.

Indications

This drug possesses antibacterial activity with respect to a few cocci and colon bacillus. It is a long-lasting drug. It is used for treating pneumonia, bronchitis, tonsillitis, purulent otitis and meningitis, purulent infections of the urinary tract, dysentery, and others. Synonyms of this drug are sulfapyridazine, sufalex, retasulfin, and many others.

Weltgesundheitsorganisation (WHO)

Sulfamethoxypyridazine, a sulfonamide anti-infective agent, was introduced in 1957 for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. The sulfonamides are known to cause serious adverse effects such as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Commercial manufacture of the drug has been discontinued by at least one major manufacturer but supplies can still be obtained on special request, particularly for patients with dermatitis herpetiformis in which condition it has been claimed to be beneficial.

Allgemeine Beschreibung

Sulfamethoxypyridazine is a sulfonamide antibiotic mainly used to prevent infections as well as conditions such as coccidiosis, diarrhea and gastroenteritis.

Pharmazeutische Anwendungen

3-Sulfanilamido-6-methoxypyridazine. Properties are similar to those of sulfadimethoxine. A rapidly absorbed, long-acting compound (half-life 38 h) with a high degree of protein binding (96%). A 1 g oral dose achieves a peak plasma concentration of around 100 mg/L after 5 h. Its use has been largely discontinued because of frequent adverse effects, but there are reports of benefit in dermatitis herpetiformis. It has been used in combination with trimethoprim.

Sulfamethoxypyridazin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Sulfamethoxypyridazin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 312)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8806 58
Hebei Mujin Biotechnology Co.,Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12831 58
Hebei Yanxi Chemical Co., Ltd.
+8617531153977
allison@yan-xi.com China 5856 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29793 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +8618949832763
info@tnjchem.com China 2986 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29879 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8618959220845
sales@amoychem.com China 6383 58
Shanghai Longyu Biotechnology Co., Ltd.
+8619521488211
info@longyupharma.com China 2558 58

80-35-3(Sulfamethoxypyridazin)Verwandte Suche:


  • Sulfanilamide, N1-(6-methoxy-3-pyridazinyl)-
  • Sulfapyridazine
  • Sulfdurazin
  • Sulfozona
  • Sultirene
  • Surirene
  • Vinces
  • Sulfamethoxopyridazine
  • SULFAMETHOXYPYRIDAZINE STANDARD SOLUTION
  • SULFAMETHOXYPYRIDAZINE VETRANAL, 250
  • sulfamethoxypyridazine solution
  • SULPHAMETHOXYPYRIDAZINE(SMP)
  • sulfadimoxine, SASP
  • N1-(6-methoxypyridazin-3-yl)sulphanilamide
  • Sulfamethoxyp
  • Sulfamethoxypyridazine Solution, 100ppm
  • sulfmethoxypyridazine
  • Sulphanyl acid N-(6-methoxypyridazin-3-yl) amide
  • 4-Amino-N-(6-methoxy-3-pyridazinyl)benzenesulfonamide N-(6-Methoxy-3-pyridazinyl)sulfanilamide
  • Depovernil
  • Durox
  • Kineks
  • Kinex
  • Kynex
  • Lederkyn
  • Lentac
  • Lisulfen
  • Longin
  • Medicel
  • Midikel
  • Myasul
  • Mylosul
  • n(sup1)-(6-methoxy-3-pyridazinyl)-sulfanilamid
  • n(sup1)-(6-methoxy-3-pyridazinyl)sulfanilamide
  • N1-(6-Methoxy-3-pyridazinyl)sulfanilamide
  • Opinsul
  • Paramid supra
  • paramidsupra
  • Petrisul
  • Piridolo
  • Quinoseptyl
  • Retamid
  • Retasulfin
  • RP 7522
  • rp7522
  • Slosul
  • Spofadazine
  • Sulfalex
  • 7522RP
  • Exazol
  • Grosul
  • 4-amino-N-(6-methoxypyridazin-3-yl)benzenesulfonamide
  • 4-azanyl-N-(6-methoxypyridazin-3-yl)benzenesulfonamide
  • N1-(6-Methoxy-d3-3-pyridazinyl)sulfanilamide, 4-Amino-N-(6-methoxy-d3-3-pyridazinyl)benzenesulfonamide
  • 3-Methoxy-6-sulfanilamidopyridazine
  • 3-Methoxy-6-sulfanylamidopyridazine
  • 3-p-Aminobenzenesulphonamido-6-methoxypyridazine
  • 3-Sulfa-6-methoxypyridazine
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