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Antidepressant. A selective norepinephrine and serotonin reuptake inhibitor approved for the management of fibromyalgia.
Allgemeine Beschreibung
Milnacipran, sold under the brand names Savella?, Ixel?, Dalcipran?, or Toledomin, is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the treatment of depression. In 2009, the US Food and Drug Administration (FDA) approved milnacipran for management of the chronic pain disorder fibromyalgia, making it only the third drug approved in the US for this indication besides duloxetine and pregabalin.
Biologische Aktivit?t
Orally active 5-HT and noradrenalin re-uptake inhibitor (SNRI) (IC 50 values are 203 and 100 nM respectively) that displays no affinity at a range of other receptors. Causes adaptive changes to α 1 -adrenergic and 5-HT 2A serotonergic systems when administered repeatedly. Exhibits antidepressive and antinociceptive activities in vivo .
(1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride Upstream-Materialien And Downstream Produkte
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Milnacipran hydrochloride
Chiral Reagents
Milnacipran hydrochloride, 98%, Serotonin and norepinephrine reuptake inhibitor
RSYYMilnacipranhydrochloride
Minapram hydrochloride
MLNACIPRAM HCL
Milnacipran hydrochloride in acetonitrile
Milnacipran hydrochloride, Serotonin and norepinephrine reuptake inhibitor
Milnacipran hydrochloride, 10 mM in DMSO
101152-94-7
C15H22N2OHClC15H23ClN2O
C15H23ClN2O
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