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1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthrachinondihydrochlorid

Mitoxantrone hydrochloride Struktur
70476-82-3
CAS-Nr.
70476-82-3
Bezeichnung:
1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthrachinondihydrochlorid
Englisch Name:
Mitoxantrone hydrochloride
Synonyma:
MITOXANTRONE HCL;novantrone;DHAQ;DHAD;Mitozantrone;IMMunex;cl232315;Novantron;Novatrone;Bisantrone
CBNumber:
CB4246424
Summenformel:
C22H30Cl2N4O6
Molgewicht:
517.4028
MOL-Datei:
70476-82-3.mol

1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthrachinondihydrochlorid Eigenschaften

Schmelzpunkt:
203-205 C
storage temp. 
2-8°C
L?slichkeit
Sparingly soluble in water, slightly soluble in methanol, practically insoluble in acetone.
Aggregatzustand
Solid
Farbe
Dark Blue to Black
Wasserl?slichkeit
Soluble to 5 mM in water and to 75 mM in DMSO
InChI
InChI=1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H
InChIKey
ZAHQPTJLOCWVPG-UHFFFAOYSA-N
SMILES
C1(O)=C2C(C(=O)C3=C(C2=O)C(NCCNCCO)=CC=C3NCCNCCO)=C(O)C=C1.[H]Cl.[H]Cl
CAS Datenbank
70476-82-3(CAS DataBase Reference)
EPA chemische Informationen
Mitoxantrone hydrochloride (70476-82-3)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T,T+
R-S?tze: 46-61-26/27/28
S-S?tze: 53-36/37/39-45-22
RIDADR  3249
WGK Germany  3
RTECS-Nr. CB5748500
HazardClass  6.1(b)
PackingGroup  III
HS Code  29146100
Giftige Stoffe Daten 70476-82-3(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H340 Kann genetische Defekte verursachen. Keimzellmutagenit?t Kategorie 1B Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" />
H360 Kann die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. Fertility (Fruchtbarkeit) Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" />
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthrachinondihydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R46:Kann vererbbare Sch?den verursachen.
R61:Kann das Kind im Mutterleib sch?digen.
R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.

S-S?tze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S22:Staub nicht einatmen.

Beschreibung

Mitoxantrone hydrochloride is the first of the synthetic anthracenediones related to doxorubicin to reach the marketplace. Mitoxantrone is useful in the treatment of advanced localized and metastatic mammary carcinomas. It is reported to be less cardiotoxic than doxorubicin.

Chemische Eigenschaften

Dark blue, electrostatic, hygroscopic powder.

Verwenden

analgesic, antipyretic

Allgemeine Beschreibung

Mitoxantrone is supplied as a blue aqueous solution in 10-and 20-mg vials for IV administration in the treatment of acute lymphoid leukemia, acute myeloid leukemia, breastcancer, prostate cancer, non-Hodgkin’s lymphoma, andmultiple sclerosis. The mechanisms of resistance are thesame as those seen for the anthracyclines. The distributionhalf-life is 1.1 to 3.1 hours, and the drug has a large volumeof distribution (11 L/kg). The elimination half-life rangedfrom 23 to 215 hours, and elimination was primarily via thebile. Metabolism of the agent involves oxidation of the sidechainalcohols to give the monocarboxylic and dicarboxylicacids.Other toxicities are those seen for the anthracyclinesand include myelosuppression, nausea, vomiting, mucositis,diarrhea, and alopecia. The intense color of the parent drugand metabolites may turn the urine blue.

Biologische Aktivit?t

Mitoxantrone hydrochloride (Mitoxantrone dihydrochloride) is a type II DNA topoisomerase inhibitor. Disrupts DNA synthesis and repair and induces damage by DNA cross-linking. Also inhibits PIM1 kinase (IC50 = 51 nM). Immunomodulatory, antineoplastic and chemotherapeutic agent. Also USP11 inhibitor (IC50= 3.15 μM). Induces cell death of pancreatic cancer cell lines expressing wild-type BRCA2.

Clinical Use

Mitoxantrone is used in combination with other agents during the initial treatment of acute nonlymphocytic leukemia and hormone-refractory prostate cancer. Recent studies have shown that mitoxantrone also decreases the rate of relapse and disease progression in patients with multiple sclerosis. Although too toxic for use in patients with primary progressive disease, it is available for the treatment of chronic progressive, progressive relapsing, or deteriorating relapsing-remitting multiple sclerosis.

Stoffwechsel

Mitoxantrone excretion primarily is biliary. Both the unchanged drug and inactive metabolites resulting from N-dealkylation, deamination, and oxidation of the resultant aldehyde to the carboxylic acid are observed. Both arms of the structure can be metabolized, leading to mono- or dicarboxylic acid metabolites, which are excreted as the glucuronide conjugate. The conjugated metabolites are an intense, dark blue in color and will result in blue-green urine.

1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthrachinondihydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthrachinondihydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 334)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Jinan Good Medical Technology Co.,Ltd
+86-53155562571 +86-008613553167512
13553167512@139.com China 23 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3009 60
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
Wuhan ChemNorm Biotech Co.,Ltd.
+86-27-8439 4403 18971486879
sales@chemnorm.com CHINA 2935 58
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
+8615377521700
wangwendy93@gmail.com China 868 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58

70476-82-3(1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthrachinondihydrochlorid)Verwandte Suche:


  • 1,4-dihydroxy-5,8-bis(2-(2-hydroxyethylamino)ethylamino)anthracene-9,10-dione dihydrochloride
  • Mitoxantrone hydrochloride 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthraquinone dihydrochloride
  • Mitoxantrone dihydrochloride, >=99%
  • MITOXANTRONE HYDROCHLORIDE
  • MITOXANTRONE HYDROCHLORIDE SALT
  • MITOXANTHRONE HCL
  • mitozantrone hydrochloride
  • DHAQ DIHYDROCHLORIDE
  • 1,4-DIHYDROXY-5,8-BIS[2-[(2-HYDROXYETHYL)AMINO]ETHYL]AMINO]-9,10-ANTHRACENEDIONE DIHYDROCHLORIDE
  • 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthraquinone dihydrochloride
  • 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)aMino]ethyl]aMino]-9,10-anthracenedione Hydrochloride
  • Bisantrone
  • IMMunex
  • NCI 301739
  • Novantron
  • Novatrone
  • Mitoxantrone hydrochloride(Mitozantrone hydrochloride
  • 1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-anthracenedion
  • cl232315
  • 1,4-DIHYDROXY-5,8-BIS-[2-(2-HYDROXYETHYLAMINO)ETHYLAMINO]ANTHRAQUINONE 2HCL
  • 1,4-Dihydroxy-5,8-bis-[2-(2-
  • NSC-301739
  • MITOXANTRONE HCL USP
  • Mitoxantrone2Hcl
  • MitoxantroneHclEp5
  • 1,4-Dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)anthrachinondihydrochlorid
  • Mitoxantron HCl
  • Mitoxantrone dihydrochloride,1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride
  • Mitoxantrone Hydrochloride (400 mg)
  • Mitoxantrone hydroch
  • Mitroxantreone hydrochloride
  • 1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)aMino]ethyl}aMino)-9,10-dihydroanthracene-9,10-dione dihydrochloride
  • MITOXANTRONE DIHYDROCHLORIDE
  • mitozantrone dihydrochloride
  • Mitoxanthrone hydrochloride
  • Mitoxantrone hydrochlorid
  • 9,10-Anthracenedione,1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-, dihydrochloride
  • Mitoxantrone hydrochloride CRS
  • Mitoxantrone hydrochloride USP/EP/BP
  • Mitoxantrone HCl (mitozantrone)
  • Mitoxantrone-D8 hydrochloride
  • Mitoxantrone Hydrochloride (1445200)
  • novantrone
  • MITOXANTRONE HCL
  • DHAQ
  • DHAD
  • Mitozantrone
  • Mitoxantrone Hydrochloride General Notices
  • Mitoxantrone DiHCl
  • 1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)anthracene-9,10-dione hydrochloride
  • Mitoxantrone (NSC-301739)2HCl
  • 70476-82-3
  • 704766-82-3
  • C22H28N4O62ClH
  • C22H28N4O62HClC22H30Cl2N4O6
  • C22H30Cl2N4O6
  • C22H28N4O62HCl
  • C22H28N4O6x2HCL
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