1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthrachinondihydrochlorid
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1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthrachinondihydrochlorid Eigenschaften
- Schmelzpunkt:
- 203-205 C
- storage temp.
- 2-8°C
- L?slichkeit
- Sparingly soluble in water, slightly soluble in methanol, practically insoluble in acetone.
- Aggregatzustand
- Solid
- Farbe
- Dark Blue to Black
- Wasserl?slichkeit
- Soluble to 5 mM in water and to 75 mM in DMSO
- InChI
- InChI=1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H
- InChIKey
- ZAHQPTJLOCWVPG-UHFFFAOYSA-N
- SMILES
- C1(O)=C2C(C(=O)C3=C(C2=O)C(NCCNCCO)=CC=C3NCCNCCO)=C(O)C=C1.[H]Cl.[H]Cl
- CAS Datenbank
- 70476-82-3(CAS DataBase Reference)
- EPA chemische Informationen
- Mitoxantrone hydrochloride (70476-82-3)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | T,T+ | ||
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R-S?tze: | 46-61-26/27/28 | ||
S-S?tze: | 53-36/37/39-45-22 | ||
RIDADR | 3249 | ||
WGK Germany | 3 | ||
RTECS-Nr. | CB5748500 | ||
HazardClass | 6.1(b) | ||
PackingGroup | III | ||
HS Code | 29146100 | ||
Giftige Stoffe Daten | 70476-82-3(Hazardous Substances Data) |
Bildanzeige (GHS) | ||||||||||||||||||||||
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Alarmwort | Achtung | |||||||||||||||||||||
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Sicherheit |
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1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthrachinondihydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R46:Kann vererbbare Sch?den verursachen.R61:Kann das Kind im Mutterleib sch?digen.
R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S22:Staub nicht einatmen.
Beschreibung
Mitoxantrone hydrochloride is the first of the synthetic anthracenediones related to doxorubicin to reach the marketplace. Mitoxantrone is useful in the treatment of advanced localized and metastatic mammary carcinomas. It is reported to be less cardiotoxic than doxorubicin.Chemische Eigenschaften
Dark blue, electrostatic, hygroscopic powder.Verwenden
analgesic, antipyreticAllgemeine Beschreibung
Mitoxantrone is supplied as a blue aqueous solution in 10-and 20-mg vials for IV administration in the treatment of acute lymphoid leukemia, acute myeloid leukemia, breastcancer, prostate cancer, non-Hodgkin’s lymphoma, andmultiple sclerosis. The mechanisms of resistance are thesame as those seen for the anthracyclines. The distributionhalf-life is 1.1 to 3.1 hours, and the drug has a large volumeof distribution (11 L/kg). The elimination half-life rangedfrom 23 to 215 hours, and elimination was primarily via thebile. Metabolism of the agent involves oxidation of the sidechainalcohols to give the monocarboxylic and dicarboxylicacids.Other toxicities are those seen for the anthracyclinesand include myelosuppression, nausea, vomiting, mucositis,diarrhea, and alopecia. The intense color of the parent drugand metabolites may turn the urine blue.Biologische Aktivit?t
Mitoxantrone hydrochloride (Mitoxantrone dihydrochloride) is a type II DNA topoisomerase inhibitor. Disrupts DNA synthesis and repair and induces damage by DNA cross-linking. Also inhibits PIM1 kinase (IC50 = 51 nM). Immunomodulatory, antineoplastic and chemotherapeutic agent. Also USP11 inhibitor (IC50= 3.15 μM). Induces cell death of pancreatic cancer cell lines expressing wild-type BRCA2.Clinical Use
Mitoxantrone is used in combination with other agents during the initial treatment of acute nonlymphocytic leukemia and hormone-refractory prostate cancer. Recent studies have shown that mitoxantrone also decreases the rate of relapse and disease progression in patients with multiple sclerosis. Although too toxic for use in patients with primary progressive disease, it is available for the treatment of chronic progressive, progressive relapsing, or deteriorating relapsing-remitting multiple sclerosis.Stoffwechsel
Mitoxantrone excretion primarily is biliary. Both the unchanged drug and inactive metabolites resulting from N-dealkylation, deamination, and oxidation of the resultant aldehyde to the carboxylic acid are observed. Both arms of the structure can be metabolized, leading to mono- or dicarboxylic acid metabolites, which are excreted as the glucuronide conjugate. The conjugated metabolites are an intense, dark blue in color and will result in blue-green urine.1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthrachinondihydrochlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Tetrachlor-p-benzochinon
2-(2-Aminoethylamino)ethanol
Dihydro-1,4,5,8-tetrahydroxyanthraquinone
N,N,N',N'-Tetramethylethylendiamin
Downstream Produkte
1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthrachinondihydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 334)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Jinan Good Medical Technology Co.,Ltd | +86-53155562571 +86-008613553167512 |
13553167512@139.com | China | 23 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21634 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3009 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29880 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39894 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49374 | 58 |
Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 |
sales@chemnorm.com | CHINA | 2935 | 58 |
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD | +8615377521700 |
wangwendy93@gmail.com | China | 868 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 32161 | 58 |
70476-82-3(1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthrachinondihydrochlorid)Verwandte Suche:
2-(Methylsulfonyl)ethanol
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Mitoxantrone HCL for Injection (Lyophilized Power)
Diethylether
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Tramadol hydrochloride
1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthrachinondihydrochlorid
- 1,4-dihydroxy-5,8-bis(2-(2-hydroxyethylamino)ethylamino)anthracene-9,10-dione dihydrochloride
- Mitoxantrone hydrochloride 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthraquinone dihydrochloride
- Mitoxantrone dihydrochloride, >=99%
- MITOXANTRONE HYDROCHLORIDE
- MITOXANTRONE HYDROCHLORIDE SALT
- MITOXANTHRONE HCL
- mitozantrone hydrochloride
- DHAQ DIHYDROCHLORIDE
- 1,4-DIHYDROXY-5,8-BIS[2-[(2-HYDROXYETHYL)AMINO]ETHYL]AMINO]-9,10-ANTHRACENEDIONE DIHYDROCHLORIDE
- 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthraquinone dihydrochloride
- 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)aMino]ethyl]aMino]-9,10-anthracenedione Hydrochloride
- Bisantrone
- IMMunex
- NCI 301739
- Novantron
- Novatrone
- Mitoxantrone hydrochloride(Mitozantrone hydrochloride
- 1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-anthracenedion
- cl232315
- 1,4-DIHYDROXY-5,8-BIS-[2-(2-HYDROXYETHYLAMINO)ETHYLAMINO]ANTHRAQUINONE 2HCL
- 1,4-Dihydroxy-5,8-bis-[2-(2-
- NSC-301739
- MITOXANTRONE HCL USP
- Mitoxantrone2Hcl
- MitoxantroneHclEp5
- 1,4-Dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)anthrachinondihydrochlorid
- Mitoxantron HCl
- Mitoxantrone dihydrochloride,1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride
- Mitoxantrone Hydrochloride (400 mg)
- Mitoxantrone hydroch
- Mitroxantreone hydrochloride
- 1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)aMino]ethyl}aMino)-9,10-dihydroanthracene-9,10-dione dihydrochloride
- MITOXANTRONE DIHYDROCHLORIDE
- mitozantrone dihydrochloride
- Mitoxanthrone hydrochloride
- Mitoxantrone hydrochlorid
- 9,10-Anthracenedione,1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-, dihydrochloride
- Mitoxantrone hydrochloride CRS
- Mitoxantrone hydrochloride USP/EP/BP
- Mitoxantrone HCl (mitozantrone)
- Mitoxantrone-D8 hydrochloride
- Mitoxantrone Hydrochloride (1445200)
- novantrone
- MITOXANTRONE HCL
- DHAQ
- DHAD
- Mitozantrone
- Mitoxantrone Hydrochloride General Notices
- Mitoxantrone DiHCl
- 1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)anthracene-9,10-dione hydrochloride
- Mitoxantrone (NSC-301739)2HCl
- 70476-82-3
- 704766-82-3
- C22H28N4O62ClH
- C22H28N4O62HClC22H30Cl2N4O6
- C22H30Cl2N4O6
- C22H28N4O62HCl
- C22H28N4O6x2HCL