Aclarubicin
|
|
|
- CAS-Nr.
- 57576-44-0
- Bezeichnung:
- Aclarubicin
- Englisch Name:
- Aclarubicin
- Synonyma:
- ACM;aclacur;Aclacin;Jaclacin;ma144-a1;Aelacinon;nsc-208734;ACLARUBLCIN;Aclaplastin;ACLARUBICIN
- CBNumber:
- CB4188966
- Summenformel:
- C42H53NO15
- Molgewicht:
- 811.88
- MOL-Datei:
- 57576-44-0.mol
|
Aclarubicin Eigenschaften
- Schmelzpunkt:
- 151-153° (dec)
- alpha
- D24 -11.5° (c = 1 in methylene chloride)
- Siedepunkt:
- 756.05°C (rough estimate)
- Dichte
- 1.2261 (rough estimate)
- Brechungsindex
- 1.6220 (estimate)
- storage temp.
- 2-8°C
- L?slichkeit
- Dichloromethane (Slightly), DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Yellow powder with orange cast.
- pka
- 6.41±0.70(Predicted)
- Farbe
- Yellow powder
- Stabilit?t:
- Light Sensitive
- CAS Datenbank
- 57576-44-0(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
T |
|
|
| R-S?tze: |
25 |
|
|
| S-S?tze: |
36/37/39-45 |
|
|
| RIDADR |
3249 |
|
|
| RTECS-Nr. |
QI9279300 |
|
|
| HazardClass |
6.1(a) |
|
|
| PackingGroup |
II |
|
|
| Toxizit?t |
LD50 in mice (mg/kg): 22.6 i.p., 33.7 i.v. (Oki) |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
|
| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P321 |
Besondere Behandlung |
| P330 |
Mund ausspülen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
|
Aclarubicin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R25:Giftig beim Verschlucken.
S-S?tze Betriebsanweisung:
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
Beschreibung
Aclarubicin was found in the culture broth of Streptomyces galilaeus MA144-M1 by Umezawa et al. of the Institute of Microbial Chemistry in 1975. It was produced along with structurally related compounds showing antileukemic activity and named aclacinomycin A. Sanraku-Ocean cooperated in isolating aclacinomycin A as a yellow crystalline powder and evaluated its strong antileukemic activity and low cardiac toxicity. Its generic name was changed to aclarubicin on the recommendation of the World Health Organization.
Verwenden
Antineoplastic.
Definition
ChEBI: An anthracycline antibiotic that is produced by Streptomyces galilaeus and also has potent antineoplastic activity.
Sicherheitsprofil
Poison by ingestion,intraperitoneal, subcutaneous, and intravenous routes. Anexperimental teratogen. Other experimental reproductiveeffects. Mutation data reported. An eye and subcutaneousirritant. When heated to decomposition it emits toxicfumes of
Enzyminhibitor
This non-peptidic aclacinomycin antibiotic (FW = 811.88 g/mol; CAS CAS 57576-44-0; Source: strain of Streptomyces galilaeus), also known as aclarubicin, induces DNA strand scission. Target(s): nitric oxide synthase; RNA biosynthesis; DNA polymerase I; RNA polymerase, Escherichia coli; reverse transcriptase, avian myeloblastosis virus; Na+/K+-exchanging ATPase; Ca2+-transporting ATPase; cyclicnucleotide phosphodiesterase; electron transport and oxidative phosphorylation, mitochondrial; DNA helicase; DNA topoisomerase II; 20S proteasome, chymotrypsin-like activity; DNA topoisomerase I; 3'-5' DNA helicase, Plasmodium falciparum.
Aclarubicin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Aclarubicin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 108)Lieferanten
57576-44-0(Aclarubicin)Verwandte Suche:
Methylacrylat
Bensulfuron methyl
3,6-Bis[(4-chlor-2-phosphonophenyl)azo]-4,5-dihydroxynaphthalin-2,7-disulfonsure
Azithromycin
Kresoxim-methyl
Oxytetracycline dihydrate
Clarithromycin
Gentamicin
[4S-(4α,4aα,5aα,12aα)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacen-2-carboxamidmonohydrochlorid
Clindamycin
N,N-Dimethyl-1,3-diaminopropan
Methyl-4-hydroxybenzoat
Methyl
Brommethan
1-Naphthacencarbonsure, 2-Ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-, Methylester, Hydrochlorid, [1R-(1α,2β,4β)]-
Amrubicin
Aclarubicin
- 1-naphthacenecarboxylicacid,2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6
- aclacur
- aclarubicinfreebase
- antibiotic3082a
- ACLARUBLCIN
- ACLARUNBICIN
- 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-, methyl ester, [1R-(1α,2β,4β)]-
- Jaclacin
- Methyl (1R,2R,4S)-4-[(2R,5S,6S)-4-dimethylamino-5-[(2S,4S,5S,6S)-4-hydroxy-6-methyl-5-[(2R,6S)-6-methyl-5-oxooxan-2-yl]oxyoxan-2-yl]oxy-6-methyloxan-2-yl]oxy-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate
- Aclacin
- Aclaplastin
- Aelacinon
- MA 144A1：NSC-208734
- Aclacinomycin(Aclarubicin)
- Methyl (1R,2R,4S)-4-[4-dimethylamino-5-[4-hydroxy-6-methyl-5-(6-methyl-5-oxo-oxan-2-yl)oxy-oxan-2-yl]oxy-6-methyl-oxan-2-yl]oxy-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate
- antibiotic77-3082a
- antibioticma144a
- antibioticma144a1
- hyl-5-oxo-2h-pyran-2-yl)-alpha-l-lyxo-hexopyranosyl)-3-(dimethylamino)-alpha-
- ma144-a1
- methylester,(1r-(1-alpha,2-beta,4-beta))-l-lyxo-hexopyranosyl)oxy)
- nsc-208734
- ACM
- ACLARUBICIN
- ACLACINOMYCIN A
- ACLACINOMYCIN A, STREPTOMYCES GALILAEUS
- ,11-dioxo-4-((2,3,6-trideoxy-4-o-(2,6-dideoxy-4-o-((2r-trans)-tetrahydro-6-met
- 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-, methyl ester, (1R,2R,4S)-
- Aclarubicin A
- Aclarubicin USP/EP/BP
- Aclidinomycin
- acclarithromycin
- 57576-44-0
- C42H53NO15
- Antibiotics
- Antibiotics A-F
- Antibiotics A to Z
- BioChemical
- Antitumour
- ProteasomeInhibitors
- Interferes with DNA Synthesis
- Antibiotics
- Antibiotics A to
- Antibiotics A-FAntibiotics
- Antibiotics by Application
- Antineoplastic and Immunosuppressive AntibioticsAntibiotics
- Mechanism of Action
