quinazoL;oro-4-phenyL;2-CHLORO-4-PHENYLQUIZOLINE;2-CHLORO-4-PHENYLQUINAZOLIN;2-Chloro-4-phenylq inazollne;2-CHLORO-4-PHENYLQUINAZOLINE;Quinazoline,2-chloro-4-phenyl-;2-CHLORO-4-PHENYLQUINAZOLINE ISO 9001:2015 REACH
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
2-Chloro-4-phenylquinazoline acts as a reagent in the synthesis of MTH1 inhibitors that are potential cancer eradicators.
Synthese
A 2 L flask was charged with 35.0 g (175.8 mmol) of 2,4-dichloroquinoline,22.5 g (184.6 mmol) of phenylboronic acid, 6.1 g (5.3 mmol) of tetrakis(triphenylphosphine)palladium(0) were added to 800 mL of tetrahydrofuran and 400 mL of water, and the mixture was heated to 60 ?? C for 12 hours under a nitrogen stream. . The resulting mixture was added to methanol (3000 mL), and the crystallized solid was filtered and dissolved in toluene, filtered through silica gel / celite, and the organic solvent was removed in an appropriate amount, and then recrystallization from methanol gave Intermediate I-A52-1 (36.8 g, 87% yield).
2-CHLORO-4-PHENYLQUINAZOLINE Upstream-Materialien And Downstream Produkte