10-((1-Methyl-3-piperidinyl)-methyl)-10H-phenothiazin-monohydrochlorid
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- CAS-Nr.
- 2975-36-2
- Bezeichnung:
- 10-((1-Methyl-3-piperidinyl)-methyl)-10H-phenothiazin-monohydrochlorid
- Englisch Name:
- 10-[(1-methyl-3-piperidyl)methyl]-10H-phenothiazine monohydrochloride
- Synonyma:
- Mepazine hydrochloride;10-((1-methylpiperidin-3-yl)methyl)-10H-phenothiazine hydrochloride;10-[(1-methyl-3-piperidyl)methyl]-10H-phenothiazine monohydrochloride;10H-Phenothiazine, 10-[(1-methyl-3-piperidinyl)methyl]-,monohydrochloride
- CBNumber:
- CB3921722
- Summenformel:
- C19H23ClN2S
- Molgewicht:
- 346.91732
- MOL-Datei:
- 2975-36-2.mol
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10-((1-Methyl-3-piperidinyl)-methyl)-10H-phenothiazin-monohydrochlorid Eigenschaften
- Schmelzpunkt:
- 180-181 °C
- Siedepunkt:
- 180-183 °C(Press: 0.5 Torr)
- storage temp.
- Store at -20°C
- L?slichkeit
- DMSO: 50 mg/mL (144.13 mM)
- Aggregatzustand
- Solid
- Farbe
- White to off-white
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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10-((1-Methyl-3-piperidinyl)-methyl)-10H-phenothiazin-monohydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden
Originator
Pacatal,Warner Lambert,US,1957
Manufacturing Process
A 500 cc flask equipped with a mechanical stirrer, reflux condenser and a soda-lime tube was filled with 230 cc of absolute xylene, 27.5 g of 1-methyl3-bromomethylpiperidine, 53.3 g of phenothiazine and 14.2 g of finely powdered sodium amide, and the solution was heated under reflux for 6 hours. After cooling water was added and the batch was extracted with ether. As the hydrochloric acid salt of the obtained phenothiazine derivative is difficultly soluble in water, the further processing was carried out by way of the acetate. The etheric solution was extracted several times in a separating funnel with dilute acetic acid. The combined aqueous extracts were basified, extracted with ether, dried with potassium carbonate and, after removal of the ether, distilled in vacuo.
Yield = 64%; boiling point 230°C to 235°C at 4 mm; melting point of
hydrochloride is 180°C to 181°C.
Therapeutic Function
Tranquilizer
10-((1-Methyl-3-piperidinyl)-methyl)-10H-phenothiazin-monohydrochlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
10-((1-Methyl-3-piperidinyl)-methyl)-10H-phenothiazin-monohydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 26)Lieferanten
- 10-[(1-methyl-3-piperidyl)methyl]-10H-phenothiazine monohydrochloride
- 10-((1-methylpiperidin-3-yl)methyl)-10H-phenothiazine hydrochloride
- 10H-Phenothiazine, 10-[(1-methyl-3-piperidinyl)methyl]-,monohydrochloride
- Mepazine hydrochloride
- 2975-36-2
