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Ginsenoside Rh2

Ginsenoside Rh2 Struktur
78214-33-2
CAS-Nr.
78214-33-2
Englisch Name:
Ginsenoside Rh2
Synonyma:
20(S)-Rh2;GINSENOSIDE RH2;Ginsenoside Rh2-RM;Ginsenoside Rh2(P);GINSENOSIDE Rh2(SH);Ginsenoside Rh2(AS);Ginsenoside Rh2 ,98%;3β-(β-D-Glucopyranosyl;R-form-Ginsenoside Rh2;Ginsenoside Rh2, 20(S)-
CBNumber:
CB3728899
Summenformel:
C36H62O8
Molgewicht:
622.88
MOL-Datei:
78214-33-2.mol

Ginsenoside Rh2 Eigenschaften

Schmelzpunkt:
139-144 °C
Siedepunkt:
726.4±60.0 °C(Predicted)
Dichte
1.19±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
L?slichkeit
DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
Aggregatzustand
Solid
pka
12.91±0.70(Predicted)
Farbe
White
InChIKey
CKUVNOCSBYYHIS-IRFFNABBSA-N
LogP
5.620 (est)
CAS Datenbank
78214-33-2(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22
S-S?tze: 24/25
WGK Germany  3
RTECS-Nr. LZ5776539
HS Code  29389090
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Ginsenoside Rh2 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Ginsenoside Rh2 is a steroid glycoside found in plants of the genus Panax that has diverse biological activities. It inhibits release of β-hexosaminidase from RBL-2H3 cells (IC50 = 100 μM) and inhibits the IgE-dependent passive cutaneous anaphylaxis reaction in mice at a dose of 25 mg/kg. It inhibits growth of HRA ovarian and BxPC-3 pancreatic cancer cells in a dose-dependent manner. In vivo, ginsenoside Rh2 decreases immobility time in the forced swim test in a mouse model of colorectal carcinoma. Ginsenoside Rh2 also reduces infarct volume in a rat model of ischemia-reperfusion-induced brain injury.

Chemische Eigenschaften

White solid

Verwenden

20(S)-Ginsenoside Rh2 is a bioactive metabolite of the ginsenoside component of Panax ginseng that has been shown to exhibit antibacterial effects in vitro.

Definition

ChEBI: A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 3 has been converted to the corresponding beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position.

Biologische Aktivit?t

Ginsenoside-Rh2, a plant glycosidewith a dammarane skeleton, has been shown to induce apoptosis in a caspase 3,8-dependent manner or the activation of cyclinA-Cdk2 by caspase 3-mediated cleavage of p21(WAF1/CIP1). Also, ginsenoside-Rh2 was shown to inhibit proliferation by inducing the protein expression of p21 and reducing the protein levels of cyclin D, which resulted in the downregulation of cyclin/Cdk complex kinase activity, a reduction in phosphorylation of pRb and the inhibition of E2F release or modulation of MAP kinases in various cancer cells[1].

Ginsenoside Rh2 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Ginsenoside Rh2 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 269)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei baicao biology science and technology co., ltd
+86-19131911055 +8617824879454
zhang@hbbocao.com China 1029 58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
+86-18791163155 +86-13119157289
13119157289@163.com China 2971 58
Chengdu Biopurify Phytochemicals Ltd.
+8618080483897
sales@biopurify.com China 3772 58
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +8617865335152
Mandy@hangyubiotech.com China 10986 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3619 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29886 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
sales@dolonchem.com CHINA 2972 58
NanJing Spring & Autumn Biological Engineering CO., LTD.
+8613815430202
sale02@cqherb.com CHINA 376 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58

78214-33-2()Verwandte Suche:


  • b-D-Glucopyranoside, (3b,12b)-12,20-dihydroxydaMMar-24-en-3-yl
  • (3β,12β)-12,20-Dihydroxydammar-24-en-3-yl-β-D-glucopyranoside
  • Ginsenoside Rh2, 20(S)-
  • (3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl beta-d-glucopyranoside
  • GINSENOSIDE RH2
  • dihydroxydammar-24-en-3-yl
  • β-D-Glucopyranoside, (3β,12β)-12,20-
  • R-form-Ginsenoside Rh2
  • 12β,20-Dihydroxy-5α-dammar-24-en-3β-yl β-D-glucopyranoside
  • 3β-(β-D-Glucopyranosyloxy)dammara-24-ene-12β,20-diol
  • 3β-(β-D-Glucopyranosyl
  • GINSENOSIDE Rh2(SH)
  • Ginsenoside Rh2 ,98%
  • 20(S)-Rh2
  • Natural Plant Extracts Ginsenoside Rh2 HPLC 15% 50% 98% 78214-33-2
  • 2-[[12-hydroxy-17-(2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
  • β-D-Glucopyranoside, (3β,12β)-12,20-dihydroxydammar-24-en-3-yl
  • Ginsenoside Rh2 USP/EP/BP
  • (2R,3R,4S,5S,6R)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
  • Ginsenoside Rk1&Rh2&Rg3
  • GINSENOSIDE Rh2 (S-FORM)(AS) 25mg
  • Ginsenoside Rh2-RM
  • Ginsenoside Rh2(AS)
  • Ginsenoside Rh2(P)
  • 78214-33-2
  • C36H62O8
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Inhibitors
  • Ginsenoside series
  • 78214-33-2
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