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Spectinomycindihydrochlorid

SPECTINOMYCIN DIHYDROCHLORIDE Struktur
21736-83-4
CAS-Nr.
21736-83-4
Bezeichnung:
Spectinomycindihydrochlorid
Englisch Name:
SPECTINOMYCIN DIHYDROCHLORIDE
Synonyma:
SPECTINOMYCIN HYDROCHLORIDE;M 141;stanilo;U-18409AE;NSC 248616;Spectacomycin;SPECTINOMYCIN 2HCL;SPECTINOMYCIN DIHYDROC;Spectinomycin (50mg/ml);Methomycin hydrochloride
CBNumber:
CB3690961
Summenformel:
C14H25ClN2O7
Molgewicht:
368.81
MOL-Datei:
21736-83-4.mol

Spectinomycindihydrochlorid Eigenschaften

Schmelzpunkt:
194°C
storage temp. 
Inert atmosphere,2-8°C
L?slichkeit
H2O: 50 mg/mL, clear, faintly yellow
Aggregatzustand
powder
Farbe
White to Off-White
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
WGK Germany  2
RTECS-Nr. WG7400000
10
Toxizit?t monkey,LD50,oral,500mg/kg (500mg/kg),Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 7, Pg. 100, 1965.
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen. Sensibilisierung der Atemwege Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" /> P261, P285, P304+P341, P342+P311,P501
Sicherheit
P261 Einatmen von Staub vermeiden.
P272 Kontaminierte Arbeitskleidung nicht au?erhalb des Arbeitsplatzes tragen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P285 Bei unzureichender Belüftung Atemschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P304+P341 BEI EINATMEN: Bei Atembeschwerden an die frische Luft bringen und in einer Position ruhigstellen, die das Atmen erleichtert
P321 Besondere Behandlung
P333+P313 Bei Hautreizung oder -ausschlag: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P342+P311 Bei Symptomen der Atemwege: GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P363 Kontaminierte Kleidung vor erneutem Tragen waschen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Spectinomycindihydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

SPECTINOMYCIN DIHYDROCHLORIDE is White Powder

Verwenden

SPECTINOMYCIN DIHYDROCHLORIDE is an antibiotic used in the treatment and control of infectious bacterial enteritis in animals. Used in drug testing against nonreplicating mycobacterium tuberculosis.

Definition

SPECTINOMYCIN DIHYDROCHLORIDE is a hydrochloride obtained by combining spectinomycin with two molar equivalents of hydrochloric acid. An antibiotic that is active against gram-negative bacteria and used (as its pentahydrate) to treat gonorrhea.

Clinical Use

The aminocyclitol antibiotic spectinomycin hydrochloride(Trobicin), isolated from Streptomyces spectabilis andonce called actinospectocin, was first described by Lewisand Clapp. Its structure and absolute stereochemistryhave been confirmed by x-ray crystallography. It occursas the white, crystalline dihydrochloride pentahydrate,which is stable in the dry form and very soluble in water.Solutions of spectinomycin, a hemiacetal, slowly hydrolyzeon standing and should be prepared freshly andused within 24 hours. It is administered by deep intramuscularinjection.
Spectinomycin is a broad-spectrum antibiotic withmoderate activity against many Gram-positive and Gramnegativebacteria. It differs from streptomycin and thestreptamine-containing aminoglycosides in chemical and antibacterialproperties. Like streptomycin, spectinomycininterferes with the binding of transfer RNA (tRNA) to the ribosomesand thus with the initiation of protein synthesis.Unlike streptomycin or the streptamine-containing antibiotics,however, it does not cause misreading of the messenger.Spectinomycin exerts a bacteriostatic action and isinferior to other aminoglycosides for most systemic infections.Currently, it is recommended as an alternative to penicillinG salts for the treatment of uncomplicated gonorrhea.A cure rate of more than 90% has been observed in clinicalstudies for this indication. Many physicians prefer to use atetracycline or erythromycin for prevention or treatment ofsuspected gonorrhea in penicillin-sensitive patients because,unlike these agents, spectinomycin is ineffective againstsyphilis. Furthermore, it is considerably more expensive thanerythromycin and most of the tetracyclines.

Sicherheitsprofil

Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx and HCl.

l?uterung methode

The salt is purified by recrystallisation from aqueous Me2CO and is soluble in H2O, MeOH and dilute acid and base, but only slightly soluble in Me2CO, EtOH, CHCl3 and *C6H6. The free base is an amorphous solid, m 184-194o with []D -20o (H2O). [Wiley et al. J Am Chem Soc 93 2652 1963, X-ray: Cochran et al. J Chem Soc Chem Commun 494 1972.] It is an aminoglycoside antibiotic which interacts with 16S ribosomal RNA [Moazet & Noller Nature 327 389 1987] and is used for the treatment of gonorrhea [Rinehart J Infect Dis 119 345 1969].

Spectinomycindihydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Spectinomycindihydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 282)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Jiangsu Guotai Guomian Trading Co. Ltd.
+86-512-58916079 +86-13601562190
pharmachem@gtgmt.com China 148 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8810 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-81148696 +86-15536356810
1022@dideu.com China 3882 58
shandong perfect biotechnology co.ltd
+86-53169958659 +86-13153181156
sales@sdperfect.com China 294 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
bruce@xrdchem.cn CHINA 566 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 296 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58

21736-83-4(Spectinomycindihydrochlorid)Verwandte Suche:


  • 8-beta,9-alpha,9a-alpha,10a-beta))-t
  • 8-bis(methylamino)-,dihydrochloride,(2r-(2-alpha,4a-beta,5a-beta,6-beta,7-be
  • (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-decahydro-4a,7,9-trihydroxy-2-Methyl-6,8-bis(MethylaMino)-4H-pyrano[2,3-b][1,4]benzodioxin-4-one Hydrochloride
  • SpectinoMycinHydrochloride for Injection
  • 4H-Pyrano[2,3-b][1,4]benzodioxin-4-one,decahydro-4a,7,9-trihydroxy-2-Methyl-6,8-bis(MethylaMino)-, hydrochloride(1:2), (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-
  • (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-4H-pyrano[2,3-b][1,4]benzodioxin-4-one, hydrochloride (1:2)
  • U-18409AE
  • SPECTINOMYCIN DIHYDROCHLORIDE
  • SPECTINOMYCIN 2HCL
  • ACTINOSPECTACIN DIHYDROCHLORIDE
  • stanilo
  • SPECTINOMYCIN READY MADE SOLUTION
  • Spectinomycin2HClpentahydrate
  • SPECTINOMYCINHYDROCHLORIDEANHYDROUS
  • 4H-Pyrano[2,3-b][1,4]benzodioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-, dihydrochloride, (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)- (9CI)
  • 4H-Pyrano[2,3-b][1,4]benzodioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-, dihydrochloride, [2R-(2a,4ab,5ab,6b,7b,8b,9a,9aa,10ab)]- (8CI)
  • NSC 248616
  • M 141
  • Raw Material Spectinomycin Dihydrochloride / Spectinomycin HCL CAS 21736-83-4
  • Spectinomycin dihydrochloride, >98%
  • SPECTINOMYCIN DIHYDROC
  • Spectinomycin Hydrochloride and Lincomycin Hydrochloride Soluble Powder
  • SPECTINOMYCIN DIHYDROCHLORIDE USP/EP/BP
  • (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-4a,7,9-Trihydroxy-2-methyl-6,8-bis(methylamino)decahydro-4H-benzo[b]pyrano[2,3-e][1,4]dioxin-4-one dihydrochloride
  • SPECTINOMYCIN HYDROCHLORIDE
  • Methanomycin hydrochloride
  • Spectinomycin (50mg/ml)
  • Spectacomycin
  • (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)octahydro-2H-benzo[b]pyrano[2,3-e][1,4]dioxin-4(3H)-one hydrochloride
  • Methomycin hydrochloride
  • SPECTINOMYCIN DIHYDROCHLORIDEv
  • Gentamicin hydrochloride
  • 21736-83-4
  • 21736-83-5
  • C14H26Cl2N2O7
  • C14H24N2O72ClH
  • C14H24N2O7HClH2O
  • C14H25ClN2O7
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