3-(((1-(((4-((Aminoiminomethyl)-amino)butyl)amino)carbonyl)-3-methylbutyl)amino)carbonyl)oxiran-carbons?ure, (2S-(2 alpha, 3 beta(R*)))
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- CAS-Nr.
- 66701-25-5
- Bezeichnung:
- 3-(((1-(((4-((Aminoiminomethyl)-amino)butyl)amino)carbonyl)-3-methylbutyl)amino)carbonyl)oxiran-carbons?ure, (2S-(2 alpha, 3 beta(R*)))
- Englisch Name:
- (L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE
- Synonyma:
- E-64;CS-1623;E-64 HCl;E64;E-64;E 64;E-64 HEMIHYDRATE;E-64 research grade;E-64 solution (10mM);thiolproteaseinhibitor;proteinaseinhibitore64;E-64 PROTEASE INHIBITOR
- CBNumber:
- CB3667057
- Summenformel:
- C15H27N5O5
- Molgewicht:
- 357.41
- MOL-Datei:
- 66701-25-5.mol
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3-(((1-(((4-((Aminoiminomethyl)-amino)butyl)amino)carbonyl)-3-methylbutyl)amino)carbonyl)oxiran-carbons?ure, (2S-(2 alpha, 3 beta(R*))) Eigenschaften
- Schmelzpunkt:
- >170°C (dec.)
- Dichte
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- H2O: 20 mg/mL, clear, colorless
- pka
- 3.16±0.40(Predicted)
- Aggregatzustand
- White solid
- Farbe
- White or off-white
- Wasserl?slichkeit
- Soluble in DMSO (25mg/ml), or water (20mg/ml)
- Sensitive
- Light Sensitive
- BRN
- 1405664
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied.
- InChIKey
- LTLYEAJONXGNFG-DCAQKATOSA-N
- SMILES
- O1[C@H](C(N[C@H](C(NCCCCNC(N)=N)=O)CC(C)C)=O)[C@H]1C(O)=O
- CAS Datenbank
- 66701-25-5(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| S-S?tze: |
22-24/25 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
RR0390000 |
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| F |
10 |
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| HS Code |
29252900 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H371 |
Kann die Organe sch?digen. |
Spezifische Zielorgan-Toxizit?t |
Kategorie 2 |
Warnung |
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P260, P264, P270, P309+P311, P405,P501 |
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| Sicherheit |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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3-(((1-(((4-((Aminoiminomethyl)-amino)butyl)amino)carbonyl)-3-methylbutyl)amino)carbonyl)oxiran-carbons?ure, (2S-(2 alpha, 3 beta(R*))) Chemische Eigenschaften,Einsatz,Produktion Methoden
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Verwenden
It is used as a broad spectrum cysteine proteinase and calpain activation inhibitor. Additionally, Prevotella intermediate studies report that E-64 blocks the breakdown of methaemoglobin and the oxidation of oxyhaemoglobin by InpA. E-64 has also been used to study excystation in Giardia lamblia. E-64 is an inhibitor of Calpain, cathepsin K and cathepsin S. E-64 is an effective ligand for affinity purification of cysteine proteases. When coupled to a thiolated affinity matrix, binding is no longer irreversible, but specificity is retained
Allgemeine Beschreibung
E-64 is a cysteine protease inhibitor that was isolated from the mold
Aspergillus japonicus TPR-64. E-64 is also known as
N-[
N-(L-3-trans-carboxyoxiran-2-carbonyl)-L-leucyl]-agmatine. E-64 effectively inhibits various cysteine proteases, in particular:
- cathepsin K
- cathepsin L
- cathepsin S
E-64 also acts against other enzymes, such as:
- calpain
- cathepsin B
- cathepsin H
- papain
Hazard
A reproductive hazard.
3-(((1-(((4-((Aminoiminomethyl)-amino)butyl)amino)carbonyl)-3-methylbutyl)amino)carbonyl)oxiran-carbons?ure, (2S-(2 alpha, 3 beta(R*))) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-(((1-(((4-((Aminoiminomethyl)-amino)butyl)amino)carbonyl)-3-methylbutyl)amino)carbonyl)oxiran-carbons?ure, (2S-(2 alpha, 3 beta(R*))) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 225)Lieferanten
66701-25-5(3-(((1-(((4-((Aminoiminomethyl)-amino)butyl)amino)carbonyl)-3-methylbutyl)amino)carbonyl)oxiran-carbons?ure, (2S-(2 alpha, 3 beta(R*))))Verwandte Suche:
- (2S,3S)-3-(((S)-1-((4-Guanidinobutyl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)oxirane-2-carboxylic acid
- (2S,3S)-3-(((S)-1-((4-Guanidinobutyl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)oxirane-2-carb
- oxiranecarboxylicacid,3-(((1-(((4-((aminoiminomethyl)amino)butyl)amino)carbon
- proteinaseinhibitore64
- thiolproteaseinhibitor
- TRANS-EPOXYSUCCINYL-L-LEUCYLAMIDO-*(4-GU ANIDINO)BUT
- (2S, 3S)-TRANS-EPOXY SUCCINYL-L-LEUCYLAMIDO-(4-GUANIDINO) BUTANE
- L-TRANS-3-CARBOXYOXIRAN-2-CARBONYL-L-LEUCYLAGMATINE
- L-TRANS-EPOXYSUCCINYL-LEU-4-GUANIDINOBUTYLAMIDE
- L-TRANS-EPOXYSUCCINYL-LEU-AGMATINE
- (L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE (E-64)
- E-64, L-trans-Epoxysuccinyl-Leu-agMatine
- 2-Oxiranecarboxylic acid, 3-[[[(1S)-1-[[[4-[(aMinoiMinoMethyl)aMino]butyl]aMino]carbonyl]-3-Methylbutyl]aMino]carbonyl]-, (2S,3S)-
- L-TRANS-EPOXYSUCCINYL-LEUCYLAMIDE-(4-GUANIDO)-BUTANE
- TRANS-EPOXYSUCCINYL-LEUCYLAMIDO-[4-GUANIDINO]BUTANE
- TRANS-EPOXYSUCCINYL-L-LEUCYL-AMIDO(4-GUANDINO)BUTANE
- TRANS-EPOXYSUCCINYL-L-LEUCYLAMIDO-(4-GUANIDINO)BUTANE
- TRANS-3-CARBOXYOXIRANE-2-CARBONYL-L-LEUCYLAGMATINE
- (2s-(2-alpha,3-beta(r*)))-yl)-3-methylbutyl)amino)carbonyl)
- e64(proteinaseinhibitor)
- 3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-(2S,3S)-oxiranecarboxylic acid
- trans-Epoxysuccinyl-L-leucylaMido(4-guanidino)butane, L-trans-3-Carboxyoxiran-2-carbonyl-L-leucylagMatine, N-(trans-Epoxysuccinyl)-L-leucine 4-guanidinobutylaMide
- (2S,3S)-3-(((S)-1-((4-Guanidinobutyl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)oxirane-2-carboxy
- EPOXYSUCCINYL-L-LEUCYLAMIDO-(4-GUANIDINO)BUTANE
- E-64 HEMIHYDRATE
- E-64 PROTEASE INHIBITOR
- EXPOXY[L-3-TRANS-CARBOXYOXIRAN-2-CARBONYL]-L-LEU-AGMATIN
- [L-3-TRANS-CARBOXY-OXIRAN-2-CARBONYL]-LEU-AGMATIN
- (L-3-TRANS-CARBOXYOXIRAN-2-CARBONYL)-L-LEUCYL-AGMATIN
- (L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYL-AGMATINE
- (L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE
- N-(TRANS-EPOXYSUCCINYL)-L-LEUCINE 4-GUANIDINOBUTYLAMIDE
- N-[N-(L-3-TRANS-CARBOXIRANE-2-CARBONYL)-L-LEUCYL]-AGMATINE
- N-[N-(L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL]-L-LEUCYL)-AGMATINE
- E-64 research grade
- CS-1623
- E64;E-64;E 64
- E-64 Protease Inhibitor - CAS 66701-25-5 - Calbiochem
- (2S,3S)-3-[[[(1S)-1-[[[4-(Aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-2-oxiranecarboxylic acid
- (L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE USP/EP/BP
- E-64 HCl
- 3-[[1-[4-(diaminomethylideneamino)butylamino]-4-methyl-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylic acid
- E-64
- Cathepsin,Inhibitor,Proteinase inhibitor E-64,inhibit,Proteinase inhibitor E64,E-64,Bacterial,Autophagy
- E-64 solution (10mM)
- 66701-25-5
- C15H27N5O5
- Biochemicals and Reagents
- BioChemical
- A to C
- Organic Covalent Modifiers
- Enzyme Inhibitors
- Enzyme Inhibitors by Type
- Enzyme Inhibitors by Enzyme
- Enzymes, Inhibitors, and Substrates
- Pepetides
- ProteaseInhibitors
- Inhibitors
