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N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide

N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide Struktur
932986-18-0
CAS-Nr.
932986-18-0
Englisch Name:
N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide
Synonyma:
CS-1554;Azoramide;Azoraminde;N-[2-[2-(4-Chlorophenyl)-4-thiazolyl]ethyl]butanamide;N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide;Butanamide, N-[2-[2-(4-chlorophenyl)-4-thiazolyl]ethyl]-;N-[2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]ethyl]butanamide
CBNumber:
CB32641660
Summenformel:
C15H17ClN2OS
Molgewicht:
308.83
MOL-Datei:
932986-18-0.mol

N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide Eigenschaften

Schmelzpunkt:
90-93°C
Dichte
1.215
storage temp. 
-20°C
L?slichkeit
Soluble in DMSO (up to at least 25 mg/ml) or in ethanol (up to at least 25 mg/ml)
Aggregatzustand
solid
Farbe
Off-white
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The unfolded protein response (UPR) maintains balance between protein synthesis and endoplasmic reticulum (ER) protein-folding by inhibiting translation to decrease global protein synthesis, increasing degradation and disposal of unfolded protein intermediates from the ER, and increasing the folding capacity of the ER by expanding its volume and increasing chaperone synthesis. Chronic ER stress leads to a defective UPR and is strongly associated with neurodegenerative diseases, cancers, and metabolic syndrome. Azoramide is a small molecule that has been shown to improve ER protein-folding ability by dose-dependently (1-25 μM) activating reporter genes whose expression is driven by the cellular UPR response element and the ER stress response element. At 1-25 μM, this compound can also stimulate the expression of multiple chaperone proteins to enhance ER chaperone capacity and induce phosphorylation of eukaryotic translation initiation factor 2α subunit (eIF2α) to reduce protein synthesis. At 150 mg/kg, azoramide exerts antidiabetic activity in both ob/ob and diet-induced obese mice, improving insulin sensitivity and glucose homeostasis, as well as protecting pancreatic β cells against ER stress.

N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 101)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32957 60
career henan chemical co
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factory@coreychem.com China 29811 58
TargetMol Chemicals Inc.
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marketing@targetmol.com United States 32161 58
Shenzhen Shengda Pharma Limited
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sales@shengdapharm.com CHINA 310 58
InvivoChem
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sales@invivochem.cn United States 6391 58
Coresyn Pharmatech Co., Ltd.
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cbc@coresyn.com China 9984 58
Nantong HI-FUTURE Biology Co., Ltd.
+undefined18051384581
sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc.

support@targetmol.com United States 38631 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054
trendseenbio@gmail.com China 11681 58

932986-18-0()Verwandte Suche:


  • Azoramide
  • N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide
  • N-[2-[2-(4-Chlorophenyl)-4-thiazolyl]ethyl]butanamide
  • Azoraminde
  • CS-1554
  • N-[2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]ethyl]butanamide
  • Butanamide, N-[2-[2-(4-chlorophenyl)-4-thiazolyl]ethyl]-
  • 932986-18-0
  • API
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