Nocodazol Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R61:Kann das Kind im Mutterleib sch?digen.
R40:Verdacht auf krebserzeugende Wirkung.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R34:Verursacht Ver?tzungen.
R11:Leichtentzündlich.
S-S?tze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S16:Von Zündquellen fernhalten - Nicht rauchen.
Beschreibung
Nocodazole reversibly binds tubulin and alters tubulin-
associated GTP hydrolysis as well as microtubule dynamics. While nocodazole is used to study many aspects on microtubule function, it is most commonly used to synchronize cell cycling in culture. Typically, nanomolar concentrations of nocodazole reduce both microtubule elongation and shortening velocities, resulting in arrest of cycling in a G
2/M phase. Nocodazole is also used to induce the formation of Golgi ministacks in eukaryotic cells.
Chemische Eigenschaften
Amber Powder
Verwenden
Nocodazole has been shown to enhance CRISPR genome editing efficiency. To see other small molecule CRISPR enhancers, visit
sigma.com/CRISPR-enhancers.
Definition
ChEBI: A member of the class of benzimidazoles that is benzimidalole which is substituted at position 2 by a (methoxycarbonyl)amino group and at position 5 by a 2-thienoyl group. It is an antineoplastic agent that exerts its effect by depolymerising microtubules.
Allgemeine Beschreibung
White powder.
Air & Water Reaktionen
Insoluble in water.
Reaktivit?t anzeigen
NOCODAZOLE may be sensitive to heat. .
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition NOCODAZOLE emits toxic fumes of sulfur oxides and nitrogen oxides.
Brandgefahr
Flash point data for NOCODAZOLE are not available; however, NOCODAZOLE is probably combustible.
Biologische Aktivit?t
Microtubule inhibitor; inhibits mitosis.
Sicherheitsprofil
Poison by intraperitoneal route.An experimental teratogen. Other experimentalreproductive effects. Human mutation data reported.When heated to decomposition it emits toxic fumes ofSOx and NOx. See also CARBAMATES
Nocodazol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
