GLIOTOXIN
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- CAS-Nr.
- 67-99-2
- Englisch Name:
- GLIOTOXIN
- Synonyma:
- S-82;GLIOTOXIN;s.n.12870;Nsc102866;Aids086418;aspergillin;Aids-086418;Gliotoxin solution;Aspergillin solution;Gliotoxin in Acetonitrile
- CBNumber:
- CB2745332
- Summenformel:
- C13H14N2O4S2
- Molgewicht:
- 326.39
- MOL-Datei:
- 67-99-2.mol
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GLIOTOXIN Eigenschaften
- Schmelzpunkt:
- 221°C (rough estimate)
- Siedepunkt:
- 699.7±55.0 °C(Predicted)
- alpha
- D25 -290° (c = 0.08 in ethanol)
- Dichte
- 1.4069 (rough estimate)
- Brechungsindex
- 1.6510 (estimate)
- Flammpunkt:
- 2℃
- storage temp.
- 2-8°C
- L?slichkeit
- chloroform: 10 mg/mL, clear, colorless
- Aggregatzustand
- White solid
- pka
- 12.90±0.40(Predicted)
- Farbe
- Monoclinic crystals from MeOH
- Merck
- 13,4454
- BRN
- 50675
- Stabilit?t:
- Stable for 2 yeara as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
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GLIOTOXIN Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R25:Giftig beim Verschlucken.
S-S?tze Betriebsanweisung:
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
Chemische Eigenschaften
White powder
Verwenden
Gliotoxin is a sulfur-containing mycotoxin produced by species of fungi and pathogens of humans. Gliotoxin exhibits inhibitory activities against histone H3K9 methyltransferase, a key enzyme in the re
gulation of transcriptional activity by writing epigenetic marks. Gliotoxin also exhibits immunosuppressive properties by causing apoptosis of cells of the immune system. In addition, various studies
suggests Gliotoxin may also be a potential anti-inflammatory, antibiotic, antifungal and antiviral agent.
Definition
ChEBI: A pyrazinoindole with a disulfide bridge spanning a dioxo-substituted pyrazine ring; mycotoxin produced by several species of fungi.
Hazard
Poison.
Biologische Aktivit?t
Immunosuppressive agent; blocks phagocytosis, cytokine production and proliferation of T and B cells. Non-competitively inhibits chymotrypsin-like activity of 20S proteasome; prevents degradation of I κ B α , an endogenous blocker of NF- κ B. Also inhibits farnesyltransferase and geranylgeranyltransferase I (IC 50 values are 80 and 17 μ M respectively) and displays antitumor activity against breast cancer in vivo .
Sicherheitsprofil
Poison by intraperitoneal andintravenous routes. When heated to decomposition itemits very toxic fumes such as SOx and NOx.
l?uterung methode
Purify gliotoxin by recrystallisation from MeOH. Its solubility in CHCl3 is 1%. The dibenzoyl derivative has m 202o (from CHCl3/MeOH). [Glister & Williams Nature 153 651 1944, Elvidge & Spring J Chem Soc Suppl 135 1949, Johnson et al. J Am Chem Soc 65 2005 1943, Bracken & Raistrick Biochem J 41 569 1947.]
GLIOTOXIN Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
GLIOTOXIN Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 128)Lieferanten
67-99-2()Verwandte Suche:
- GLIOTOXIN
- GLIOTOXIN, GLADIOCLADIUM FIMBRIATUM
- 2,3,5A,6-TETRAHYDRO-6-HYDROXY-3(HYROXYMETHYL)-2-METHYL-10H-3A, 10A-EPIDITHIO-PYRAZINOL[1,2ALPHA]INDOLE-1,4-DIONE
- (3r-(3-alpha,5a-beta,6-beta,10a-alpha))-ymethyl)-2-methyl
- 10h-3,10a-epidithiopyrazino(1,2-a)indole-1,4-dione,2,3,5a,6-hydroxy-3-(hydrox
- aspergillin
- s.n.12870
- gliotoxin from gliocladium fimbriatum
- GLIOTOXIN FROM GLIOCLADIUM VIRENS
- 10H-3,10a-Epidithiopyrazino1,2-aindole-1,4-dione, 2,3,5a,6-tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-, (3R,5aS,6S,10aR)-
- (3R)-2-Methyl-3-(hydroxymethyl)-6β-hydroxy-3α,10aα-epidithio-1,2,3,4,5aβ,6,10,10a-octahydropyrazino[1,2-a]indole-1,4-dione
- 2,3,5aβ,6-Tetrahydro-6β-hydroxy-3β-(hydroxymethyl)-2-methyl-10H-3α,10aα-epidithiopyrazino[1,2-a]indole-1,4-dione
- S-82
- 6-Hydroxy-3-(hydroxymethyl)-2-methyl-2,3,6,10-tetrahydro-5ah-3,10A-epidithiopyrazino[1,2-A]indole-1,4-dione
- Aids086418
- Aids-086418
- Nsc102866
- (3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epidithiopyrazino[1,2-a]indole-1,4-dione
- Aspergillin, SN 12879, SN 12870
- Aspergillin solution
- Gliotoxin solution
- Gliotoxin, Gladiocladium fimbriatum - CAS 67-99-2 - Calbiochem
- Gliotoxin, 99%, from Gliocladium fimbriatum
- Gliotoxin, 98%, from Gliocladium fimbriatum
- GliotoxinQ: What is
Gliotoxin Q: What is the CAS Number of
Gliotoxin Q: What is the storage condition of
Gliotoxin Q: What are the applications of
Gliotoxin
- Gliotoxin in Acetonitrile
- Gliotoxin, NF-kappaB inhibitor
- 67-99-2
- C13H14N2O4S2
- Antibiotics
- Antibiotics A to Z
- Antibiotics G-M
- BioChemical
- antibiotic
