Sodium taurodeoxycholate hydrate
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- CAS-Nr.
- 207737-97-1
- Englisch Name:
- Sodium taurodeoxycholate hydrate
- Synonyma:
- 5β12αsodium 2-[[(3αSodium taurodeoxycholate, ≥99%;SODIUM TAURODEOXYCHOLATE HYDRATE;N-(Deoxycholyl)taurine sodium salt;SODIUM TAURODEOXYCHOLATE HYDRATE BIO;Taurodeoxycholic acid sodium hydrate;Taurodeoxycholic Acid-[d6] Sodium Salt;2H6]-Taurodeoxycholic Acid Sodium Salt
- CBNumber:
- CB2547459
- Summenformel:
- C26H48NNaO7S
- Molgewicht:
- 541.72
- MOL-Datei:
- 207737-97-1.mol
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Sodium taurodeoxycholate hydrate Eigenschaften
- Schmelzpunkt:
- 168 °C (dec.)(lit.)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- L?slichkeit
- H2O: soluble0.5M, clear, colorless to faintly yellow
- Aggregatzustand
- A crystalline solid
- Farbe
- White to off-white
- BRN
- 3901204
- InChIKey
- GFBBTUJLLSJWQW-RIIXSHNENA-N
- SMILES
- C[C@]12[C@H](C[C@]3([H])[C@]4(CC[C@@H](O)C[C@@]4([H])CC[C@@]3([H])[C@]1([H])CC[C@]2([H])[C@H](C)CCC(=O)NCCS(O)(=O)=O)C)O.[NaH].O |&1:1,2,4,6,9,12,16,18,22,24,r|
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| HS Code |
29242998 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P321 |
Besondere Behandlung |
| P332+P313 |
Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P362 |
Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen. |
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Sodium taurodeoxycholate hydrate Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Sodium taurodeoxycholate hydrate is a bile salt-related, anionic detergent used for isolation of membrane proteins including inner mitochondrial membrane proteins. It has also been used in a study to investigate polymorphic behavior in protein surfactant mixtures.
Sodium taurodeoxycholate hydrate has been used in a study to assess the effect of submicellar concentrations of bile salts on the lipid bilayer membrane. It has also been used in a study to investigate polymorphic behavior in protein-surfactant mixtures.
Verwenden
A hydrate form of sodium taurodeoxycholate (T009005), a steroid which rescues human colon cancer cells from apoptosis by activating EGFR-dependent PI3K/Akt signaling.
Allgemeine Beschreibung
Sodium tauroursodeoxycholate is a bile salt which is naturally present in the small bowel.
l?uterung methode
The Na salt is dissolved in the smallest volume of H2O, a saturated solution of aqueous NaCl/Et2O is added and the mixture is stored at 0o for 24hours. Then shake the mixture well, keep it in the cold for another day and filter the crystals with gentle shaking, wash them with ice-cold saturated aqueous NaCl saturated with Et2O, dry them over CaCl2 and extract them with absolute EtOH. Add ~10mL of H2O to the solid followed by enough Et2O to incipient cloudiness. Store it overnight at 0o. Add ice-cold Et2O to make 250mL, collect the crystals, wash them with Et2O then pet ether and dry them in air. The purification can be repeated with NaCl and Et2O with ~85% recovery. NB: precipitation will not occur unless enough H2O is present. Its solubility in H2O is 10%. [Cortese J Am Chem Soc 59 2532 1937.] The free acid has m 141-144o. [Norman Ark Kemi 8 331 1956.] It forms mixed micelles and solubilises some membrane proteins [Hajjar et al. J Biol Chem 2 5 8 192 1983]. [Beilstein 10 IV 1611.]
Mode of action
Sodium taurodeoxycholate hydrate functions as a surfactant in experimental applications. It reduces the surface tension of liquids, allowing for improved solubility and dispersion of substances in aqueous solutions. Sodium Taurodeoxycholate Hydrate interacts with lipid molecules, disrupting their organization and facilitating the emulsification of fats. Sodium taurodeoxycholate hydrate also plays a role in cell membrane permeabilization, aiding in the uptake of hydrophobic compounds by cells. At the molecular level, Sodium taurodeoxycholate hydrate interacts with cholesterol and phospholipids, influencing their arrangement and fluidity within lipid bilayers. It can form micelles, which assist in solubilising poorly water-soluble substances for experimental purposes.
Sodium taurodeoxycholate hydrate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Sodium taurodeoxycholate hydrate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 168)Lieferanten
207737-97-1()Verwandte Suche:
- 2-[[(3alpha,5beta,12alpha)-3,12-Dihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid monosodium salt hydrate
- TAURODEOXYCHOLIC ACID SODIUM SIGMAULTRA
- 2-([3α,12α-dihydroxy-24-oxo-5β-cholan-24-yl]amino)ethanesulfonic acid
- Taurodeoxycholic acid hydrate sodium salt, 2-([3α,12α-Dihydroxy-24-oxo-5β-cholan-24-yl]amino)ethanesulfonic acid
- N-(Deoxycholyl)taurine sodium salt, Taurodeoxycholic acid sodium salt, 3α,12α-Dihydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide sodium salt
- Sodium taurodeoxycholate hydrate,2-([3α,12α-Dihydroxy-24-oxo-5β-cholan-24-yl]amino)ethanesulfonic acid, Taurodeoxycholic acid sodium salt hydrate
- Ethanesulfonic acid,2-[[(3a,5b,12a)-3,12-dihydroxy-24-oxocholan-24-yl]aMino]-, sodiuM salt, hydrate (1:1:)
- 3α,12α-Dihydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide sodium salt
- N-(Deoxycholyl)taurine sodium salt
- 2-([3α,12α-Dihydroxy-24-oxo-5β-cholan-24-yl]amino)ethanesulfonic acid, Taurodeoxycholic acid sodium salt hydrate
- SODIUM TAURODEOXYCHOLATE HYDRATE BIO
- SODIUM TAURODEOXYCHOLATE HYDRATE
- Taurodeoxycholic Acid sodium salt hydrat
- Taurodeoxycholic Acid-[d6] Sodium Salt
- Taurodeoxycholic acid sodium hydrate
- Sodium Taurodeoxycholate Hydrate
See T009005
- Sodium taurodeoxycholate, ≥99%
- Taurodeoxycholic Acid-D4 Sodium Salt DiHydrateQ: What is
Taurodeoxycholic Acid-D4 Sodium Salt DiHydrate Q: What is the CAS Number of
Taurodeoxycholic Acid-D4 Sodium Salt DiHydrate Q: What is the storage condition of
Taurodeoxycholic Acid-D4 Sodium Salt DiHydrate Q: What are the applications of
Taurodeoxycholic Acid-D4 Sodium Salt DiHydrate
- Sodium Taurodeoxycholate HydrateQ: What is
Sodium Taurodeoxycholate Hydrate Q: What is the CAS Number of
Sodium Taurodeoxycholate Hydrate Q: What is the storage condition of
Sodium Taurodeoxycholate Hydrate Q: What are the applications of
Sodium Taurodeoxycholate Hydrate
- sodium 2-{[(3alpha,5beta,12alpha)-3,12-dihydroxy-24-oxocholan-24-yl]amino}ethanesulfonate hydrate
- Sodium Taurodeoxycholate Hydrate (STDC Hydrate) extrapure, 97%
- Sodium 2-[[(3α,5β,12α)-3,12-dihydroxy-24-oxocholan-24-yl]amino]ethanesulfonate hydrate (1:1:?)
- Sodium 2-((R)-4-((3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)ethanesulfonate xhydrate
- 2H6]-Taurodeoxycholic Acid Sodium Salt
- 12α
- 5β
- sodium 2-[[(3α
- Taurodeoxycholic Acid-[d6] Sodium Salt in Methanol
- Taurodeoxycholic Acid Sodium Salt Hydrate in Methanol
- 207737-97-1
- C26H46NO6SxH2ONa
