2,3-BIS(4-HYDROXYPHENYL)-PROPIONITRILE
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- CAS-Nr.
- 1428-67-7
- Englisch Name:
- 2,3-BIS(4-HYDROXYPHENYL)-PROPIONITRILE
- Synonyma:
- DPN;SC-4473;DPN, 10 mM in DMSO;Diarylpropionitrile;DPN, ERbeta agonist;2,3-bis(p-hydroxyphenyl)propionitrile;propionitrile,2,3-bis(p-hydroxyphenyl);2,3-BIS(4-HYDROXYPHENYL)-PROPIONITRILE;2,3-Bis(4-hydroxyphenyl)propanenitrile;2,3-Bis(4-hydroxyphenyl)propiononitrile
- CBNumber:
- CB2379797
- Summenformel:
- C15H13NO2
- Molgewicht:
- 239.27
- MOL-Datei:
- 1428-67-7.mol
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2,3-BIS(4-HYDROXYPHENYL)-PROPIONITRILE Eigenschaften
- Schmelzpunkt:
- 200.0 to 204.0 °C
- Siedepunkt:
- 449.4±35.0 °C(Predicted)
- Dichte
- 1.256±0.06 g/cm3(Predicted)
- RTECS-Nr.
- UG0900000
- storage temp.
- -20°C
- L?slichkeit
- DMSO: soluble10mg/mL, clear
- Aggregatzustand
- powder
- pka
- 9.41±0.26(Predicted)
- Farbe
- white to beige
- Wasserl?slichkeit
- Soluble in 1eq. NaOH (30 mM), ethanol (100 mM), DMSO (100 mM), DMF (~30 mg/ml), and water (0.5 mg/ml at 25°C).
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
2,3-BIS(4-HYDROXYPHENYL)-PROPIONITRILE Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
2,3-Bis(4-hydroxyphenyl)propionitrile is an estrogen receptor β and α specific with pro- and anti-nociceptive actions in mice.
Definition
ChEBI: A nitrile that is acetonitrile in which one of the hydrogens is replaced by a 4-hydroxyphenyl group while a second hydrogen is replaced by a 4-hydroxybenzyl group. It is a specific agonist for estrogen receptor beta (ERbeta).
Biologische Aktivit?t
Highly potent estrogen ER β receptor agonist with a 70-fold selectivity over ER α (EC 50 values are 0.85 and 66 nM respectively). Relaxes mesenteric arteries in vitro .
2,3-BIS(4-HYDROXYPHENYL)-PROPIONITRILE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2,3-BIS(4-HYDROXYPHENYL)-PROPIONITRILE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 91)Lieferanten
1428-67-7()Verwandte Suche:
- 2,3-BIS(4-HYDROXYPHENYL)-PROPIONITRILE
- 2,3-bis(p-hydroxyphenyl)propionitrile
- propionitrile,2,3-bis(p-hydroxyphenyl)
- SC-4473
- Diarylpropionitrile
- 2,3-Bis(4-hydroxyphenyl)propanenitrile
- 2,3-Bis(4-hydroxyphenyl)propiononitrile
- 4-Hydroxy-alpha-(4-hydroxyphenyl)benzenepropanenitrile
- 2,3-Bis(4-hydroxyphenyl)propionitrile >
- Benzenepropanenitrile, 4-hydroxy-α-(4-hydroxyphenyl)-
- DPN
- inhibit,neuroprotection,estrogen,beta,anti-inflammation,receptor,Autophagy,peptide,amyloid,DPN,Inhibitor,anxiety-like,Estrogen Receptor/ERR,Alzheimer's,Apoptosis,antioxidant,disease,behaviors
- DPN, ERbeta agonist
- DPN, 10 mM in DMSO
- 1428-67-7
- Miscellaneous
- Intracellular receptor
- Nuclear Receptors
- Diarylpropionitrile
