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Triptorelin

Triptorelin Struktur
57773-63-4
CAS-Nr.
57773-63-4
Englisch Name:
Triptorelin
Synonyma:
TRIPTORELIN PAMOATE;Triptorelin/GnRH;PGLU-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2;CL-118532;TRIPORELIN;Decapeptyl;Triptoreli;TRIPTORELIN;Tryptorelin;Triprerelin
CBNumber:
CB2366465
Summenformel:
C64H82N18O13
Molgewicht:
1311.45
MOL-Datei:
57773-63-4.mol

Triptorelin Eigenschaften

Schmelzpunkt:
>180°C (dec.)
alpha 
D23 -58.8° (c = 0.33 in acetic acid)
Dichte
1.52±0.1 g/cm3(Predicted)
storage temp. 
-20°C
L?slichkeit
Aqueous Base (Slightly), Methanol (Very Slightly, Heated, Sonicated)
Aggregatzustand
powder
pka
9.82±0.15(Predicted)
Farbe
White to Off-White
Stabilit?t:
Hygroscopic
InChIKey
HPPONSCISKROOD-OYLNGHKZSA-N
CAS Datenbank
57773-63-4(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T
R-S?tze: 60
S-S?tze: 53-22-36/37/39-45
WGK Germany  3
HS Code  2937190000
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H360 Kann die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. Fertility (Fruchtbarkeit) Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" />
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Triptorelin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R60:Kann die Fortpflanzungsf?higkeit beeintr?chtigen.

S-S?tze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Beschreibung

Decapeptyl is a modified (D-Trp6) LH-RH. Like recently marketed buserelin and leuprolide (I), it is useful in achieving medical castration in the treatment of advanced prostate cancer.

Verwenden

Triptorelin is a GnRH agaonist shown to inhibit estradiol-induced cancer cell proliferation.

Definition

ChEBI: An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-tryptophyl, leucyl, arginyl, prolyl and glycinamide residues joined in sequence. It is an agonist analogue of gonadotropin-releasing hormone.

Clinical Use

Triptorelin pamoate is another superagonist of GnRH, which like nafarelin acetate contains only a single amino acid substitution (D-Trp6 for Gly6) when compared to the natural hormone. In the treatment of advanced prostate cancer, it is important to reduce serum testosterone levels to very low levels, which can be achieved surgically by orchiectomy. When this surgical method is unacceptable to the patient, an alternative approach is “chemical castration,” which can be achieved by use of estrogen therapy, leuprolide,goserelin or histrelin acetates, and now, triptorelin pamoate. This product is available for IM depot injection (monthly or every 3 months), wherein serum testosterone concentration drops to a level generally seen in surgically castrated men.

Nebenwirkungen

The side effects of Triptorelin: Painful or difficult urination, burning when you urinate, blood in the urine; bone pain; (in children) new or worsening signs of puberty; a seizure; chest pain or pressure, pain spreading to your jaw or shoulder; sudden numbness or weakness, slurred speech; increased pressure inside the skull - severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes; loss of movement in any part of your body; high blood sugar - increased thirst, increased urination, hunger, dry mouth, fruity breath odor; or nerve problems - back pain, muscle weakness, problems with balance or coordination, severe numbness or tingling in your legs or feet, loss of bladder or bowel control.

Triptorelin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Triptorelin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 347)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Cellmano Biotech Limited
0551-65326643 18156095617
info@cellmano.com China 999 58
Apextide Co Ltd
+86-15300650552 +86-15300650552
info@apextide.com China 92 58
hebei hongtan Biotechnology Co., Ltd
+86-86-1913198-3935 +8617331935328
sales03@chemcn.cn China 970 58
Apeloa production Co.,Limited
+8619933239880
admin@apcl.com.cn China 852 58
Hangzhou Hyper Chemicals Limited
+86-0086-57187702781 +8613675893055
info@hyper-chem.com China 295 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8810 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12835 58
Shanghai Yunao International Trade Co., Ltd
+8617621705551
asdf@shanghaihg.cn China 264 58
qingdao future trading Co., Ltd
+86-13335044410 +86-13335044410
cui56813@163.com China 110 58
Shandong Huisheng Import & Export Co., Ltd.
+86-13176845580 +86-13176845580
da@zhongda-biotech.com China 232 58

57773-63-4()Verwandte Suche:


  • PYROGLU-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY NH2
  • PYR-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2
  • PYR-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2 PAMOATE SALT
  • TRIPTORELIN AMIDE
  • TRIPTORELIN, [DTRP6]-LH-RH, AMIDE
  • TRIPTORELINE
  • [D-Trp6]-LH-RH,[D-Trp6]-Luteinizing hormone releasing hormone
  • (D-Trp6)-LHRH Triptorelin, (D-Trp6)-GnRH
  • Triptorelin, (D-Trp6)-GnRH
  • Triptorelin Acetate /GnRH Triptorelin
  • Luteinizing hormone-releasing factor (swine), 6-D-tryptophan-
  • GLP-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2
  • (D-TRP6)-LHRH PAMOATE SALT
  • (D-TRP6)-LUTEINIZING HORMONE-RELEASING FACTOR
  • (D-TRP6)-LUTEINIZING HORMONE-RELEASING HORMONE
  • [DTRP6]-LUTEINIZING HORMONE-RELEASING HORMONE, AMIDE
  • (D-TRP6)-LHRH
  • [D-TRP6]-LH-RH (HUMAN)
  • [DTRP6]-LH-RH AMIDE
  • [D-TRP6]-LUTEINIZING HORMONE-RELEASING HORMONE (HUMAN)
  • TRIPTORELIN
  • (D-TRP6)-GONADOTROPIN-RELEASING HORMONE
  • TRIPTORELIN, 98+%
  • TRIPORELIN
  • TRIPTERYGLLHYPOGLAUCIDRIEDPOWDER
  • 6-D-TRYPTOPHAN-LUTEINIZING HORMONE-RELEASING FACTOR (SWINE)
  • Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2 acetate salt
  • 5-Oxo-L-Pro-L-His-L-Trp-L-Ser-L-Tyr-D-Trp-L-Leu-L-Arg-L-Pro-Gly-NH2
  • CL-118532
  • Decapeptyl
  • GLP-HIS-TRP-SER-TYR-DTRP-LEU-ARG-PRO-GLY-NH2: GLP-HWSW-DW-LRPG-NH2
  • Triptorelin Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2
  • Triptorelin, Triptoreline, Triptorelina, Triptorelinum
  • triptorelinum
  • Tryptorelin
  • Triptorelin-d4 Trifluoroacetate (Mixture ofIsomers)
  • (S)-1-((3S,6S,9S,12S,15R,18S,21S)-3-((1H-imidazol-5-yl)methyl)-6,15-bis((1H-indol-3-yl)methyl)-21-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-(hydroxymethyl)-18-isobutyl-1,4,7,10,13,16,19-heptaoxo-1-((S)-5-oxopyrrolidin-2-yl)-2,5,8,11,14,17,20-heptaazadocosan-22-oyl)-N-(2-amino-2-oxoethyl)pyrrolidine-2-carboxamide
  • Peptides Peptide Triptorelin Powder Triptorelin Acetate 2mg
  • Triptorelin USP/EP/BP
  • Palmitoyl-GQPR / Palmitoyl Tetrapeptide-3
  • Triptoreli
  • Triptorelin Acctate
  • Triptorelin Acetate(GnRH Triptorelin) 2mg
  • Triptorelin Acetate(net)
  • PGLU-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2
  • TRIPTORELIN PAMOATE
  • Triptorelin/GnRH
  • Triptorelin acetate salt
  • Triptorelin Acetate/Pamoate
  • Triprerelin
  • Triptorelin Acetate (1.82 mg) (5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolylglycinamide acetate salt) (COLD SHIPMENT REQUIRED)
  • Triptorelin patch
  • Triptorelin Acetate/GnRH
  • 57773-63-4
  • 149194-24-7
  • C64H83N18O13
  • C64H82N18O13
  • C66H88N18O15
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