N-Hydroxyphthalimid
|
|
|
- CAS-Nr.
- 524-38-9
- Bezeichnung:
- N-Hydroxyphthalimid
- Englisch Name:
- N-Hydroxyphthalimide
- Synonyma:
- nhpi;2-hydroxyisoindoline-1,3-dione;hydroxyphthalimide;2-hydroxyisoindole-1,3-dione;1H-Isoindole-1,3(2H)-dione, 2-hydroxy-;HOPHT;H-HYDROXY PHTHALIMIDE;2-Hydroxy-1H-isoindole-1,3(2H)-dione;2-hydroxy-2,3-dihydro-1H-isoindole-1,3-dione;f802
- CBNumber:
- CB2332640
- Summenformel:
- C8H5NO3
- Molgewicht:
- 163.13
- MOL-Datei:
- 524-38-9.mol
|
N-Hydroxyphthalimid Eigenschaften
- Schmelzpunkt:
- 233 °C (dec.) (lit.)
- Siedepunkt:
- 290.19°C (rough estimate)
- Dichte
- 1.64 g/cm3
- Dampfdruck
- 0Pa at 25℃
- Brechungsindex
- 1.5510 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- pka
- 6.10±0.20(Predicted)
- Aggregatzustand
- Powder
- Farbe
- Yellow
- Wasserl?slichkeit
- Slightly soluble in water.
- Merck
- 14,4838
- BRN
- 131208
- InChIKey
- CFMZSMGAMPBRBE-UHFFFAOYSA-N
- LogP
- 0.14
- CAS Datenbank
- 524-38-9(CAS DataBase Reference)
- EPA chemische Informationen
- 1H-Isoindole-1,3(2H)-dione, 2-hydroxy- (524-38-9)
N-Hydroxyphthalimid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
N-Hydroxyphthalimide is yellow moist powder
Verwenden
N-Hydroxyphthalimide，additives in to DCC method of peptide synthesis used to improve yield of optically pure product.
Application
N-Hydroxyphthalimide is used in the synthesis of a new class of antibacterials potent against macrolide resistant bacteria. Also used in the synthesis of pyrazolidines, isoxazolidines and tetrahydrooxazines.
l?uterung methode
N -Hydroxyphthalimide [524-38-9] M 163.1, m 230o, ~235o(dec), 237-240o, 7.0. Dissolve the imide in H2O by adding Et3N to form the salt and while hot, acidify, cool and pour into a large volume of H2O. Filter off the solid, wash it with H2O and dry it over P2O5 in a vacuum. [Nefken & Teser J Am Chem Soc 83 1263 1961, Fieser 1 485 1976, Nefkens et al. Recl Trav Chim, Pays-Bas 81 683 1962] The O-acetyl derivative has m 178-180o (from EtOH). [Beilstein 21/11 V 100.]
N-Hydroxyphthalimid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
2H-Isoindole-2-carboxylic acid, 1,3-dihydro-1,3-dioxo-, 1,1-dimethylethyl ester
1,3-dioxoisoindolin-2-yl acetate
Benzenebutanoic acid, α-methylene-, ethyl ester
Benzoic acid, 2-[(hydroxyamino)carbonyl]-
2,4-DIPHENYL-1-BUTENE-D5
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-phenyl-L-alanin
2-phenylmethoxyisoindole-1,3-dione
1,1'-(1,1-Dimethyl-3-methylen-1,3-propandiyl)bisbenzol
Phthaloyldichlorid
Downstream Produkte
N-Hydroxyphthalimid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 589)Lieferanten
524-38-9(N-Hydroxyphthalimid)Verwandte Suche:
- TIMTEC-BB SBB009098
- N-HYDROXY-PHTALIMIDE
- N-HYDROXYPHTHALIMIDE
- 2-hydroxy-1h-isoindole-3(2h)-dione
- N-Hydroxyphthalimide, remainder 10-15% moisture
- N-Hydroxyphehtalimide
- N-HYDROXYMETHYL-3-METHYLOXETANE
- N-Hydroxyphthalimide(Nop)
- N-Hydroxyphthalimide,98+%
- N-Hydroxyphthalimide,99%
- N-Hydroxymethyl-3-methyloxetane（N-Hydroxyphthalimide
- N-(hydroxy)phthaltmde
- N-HYDROXYPHTHALIMIDE pure
- PHTHALOXIME
- 2-Hydroxy-2H-isoindole-1,3-dione
- Phthalimidyl alcohol
- NHPI NOP
- N-Hydroxyphthalimide, remainder 10-15% moisture,99%
- N-(hydroxy)phthaltmd
- N-(HYDROCU)PHTHALIMDE
- 2-hydroxyphthalimide
- Phthalimide,N-hydroxy-
- N-Hydroxyphthalimide
- N-Hydroxyphthalimide Vetec(TM) reagent grade, 97%
- N-Hydroxyphthalimide≥ 99% (Assay)
- f802
- n-hydroxy-phthalimid
- AURORA KA-3774
- LABOTEST-BB LT00005723
- N-HYDROXYPHTHALIMIDE FOR SYNTHESIS
- 2-Hydroxy-1H-isoindole-1,3(2H)-dione, 2-Hydroxyisoindolin-1,3-dione
- N - hydroxy phthalates forMyl aMine
- N-HydroxyphthaL
- N-Hydroxyphthalimide>
- N-Hydroxyphthalimide, 98%, for synthesis
- Droxidopa Impurity 14
- N-Hydroxyphthalimide USP/EP/BP
- 1H-Isoindole-1,3(2H)-dione, 2-hydroxy-
- nhpi
- 2-hydroxyisoindole-1,3-dione
- 2-hydroxyisoindoline-1,3-dione
- 2-Hydroxy-1H-isoindole-1,3(2H)-dione
- hydroxyphthalimide
- HOPHT
- H-HYDROXY PHTHALIMIDE
- 2-hydroxy-2,3-dihydro-1H-isoindole-1,3-dione
- N-Hydrophthalimide
- 524-38-9
- Carbon Radical Producing Catalysts (Environmentally-friendly Oxidation)
- Peptide Synthesis
- Condensation & Active Esterification
- Coupling Reactions (Peptide Synthesis)
- Coupling
- Synthetic Reagents
- Environmentally-friendly Oxidation
- N-Substituted Maleimides, Succinimides & Phthalimides
- N-Substituted Phthalimides
- Active Esters/Additives
