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N-Hydroxysuccinimid

N-Hydroxysuccinimide Struktur
6066-82-6
CAS-Nr.
6066-82-6
Bezeichnung:
N-Hydroxysuccinimid
Englisch Name:
N-Hydroxysuccinimide
Synonyma:
NHS;HOSU;1-HYDROXY-PYRROLIDINE-2,5-DIONE;Hydroxysuccinimide;HONSU;2,5-PYRROLIDINEDIONE, 1-HYDROXY-;N-HYDROXYSUCCINIMDE;N-HYDROXYSUCCINAMIDE;1-Hydroxysuccinimide;1-HYDROXY-2,5-PYRROLIDINEDIONE
CBNumber:
CB0391283
Summenformel:
C4H5NO3
Molgewicht:
115.09
MOL-Datei:
6066-82-6.mol

N-Hydroxysuccinimid Eigenschaften

Schmelzpunkt:
95-98 °C(lit.)
Siedepunkt:
215.33°C (rough estimate)
Dichte
1.4769 (rough estimate)
Dampfdruck
0Pa at 25℃
Brechungsindex
1.4080 (estimate)
storage temp. 
Store at +2°C to +8°C.
L?slichkeit
DMSO (Soluble), Methanol (Slightly)
Aggregatzustand
Liquid or Solid
pka
7.81±0.20(Predicted)
Farbe
Clear yellow-brown to brown
PH
5-7 (50g/l, H2O, 20℃)
Wasserl?slichkeit
SOLUBLE
Sensitive 
Hygroscopic
BRN 
113913
Stabilit?t:
Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, strong bases. Protect from moisture.
InChIKey
NQTADLQHYWFPDB-UHFFFAOYSA-N
LogP
-2.01
CAS Datenbank
6066-82-6(CAS DataBase Reference)
NIST chemische Informationen
N-hydroxylsuccinimide(6066-82-6)
EPA chemische Informationen
2,5-Pyrrolidinedione, 1-hydroxy- (6066-82-6)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 22-24/25-26-36
WGK Germany  3
Hazard Note  Irritant
TSCA  Yes
HS Code  29251995
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H318 Verursacht schwere Augensch?den. Schwere Augensch?digung Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS05.jpg" width="20" height="20" /> P280, P305+P351+P338, P310
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P332+P313 Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

N-Hydroxysuccinimid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

N-hydroxysuccinimide is a synthetic ingredient used in cosmetics as an ester to soften and condition skin. It's also a reagent, a substance used to trigger a reaction that leads to a new substance, such as peptides and polymers.
N-Hydroxysuccinimide is used in cosmetics and beauty products as an ester often seen in eye creams. N-hydroxysuccinimide activates the elimination of blood originated pigments responsible for dark color and inflammation that causes under eye circles. "Infra-orbital shadows are due to the accumulation of hemoglobin and its coloured degradation products - biliverdin, bilirubin and iron - in the dermis and epidermis ... N-hydroxysuccinimide renders the iron soluble for natural elimination" (source).

Chemische Eigenschaften

White to pale yellow

Verwenden

N-hydroxysuccinimide (NHS) is often used to assist carbodiimide-mediated peptide coupling by forming an active ester intermediate via condensation of the surface carboxyl group and NHS. The NHS-reactive ester intermediate is susceptible to nucleophilic attack by primary amines and results in the formation of stable amide bonds between the biomaterial surface and the N-terminus of the peptide.

Application

N-Hydroxysuccinimide has been used in the synthesis of intermediates such as:
N-succinimidyl 3-(di-tert-butylfluorosilyl)benzoate
4-[2,2-bis[(p-tolylsulfonyl)-methyl] acetyl]benzoic acid-NHS ester
N-succinimidyl 3-iodobenzoate
It has also been used in a protocol for the surface modification of microchannels of a microfluidic-integrated surface plasmon resonance (SPR) platform for the detection and quantification of bacterial pathogens.
Additive used in the carbodiimide method for improved amidations and peptide couplings.
N-Hydroxysuccinimide can be used in the synthesis of N-hydroxysuccinimide ester via dehydration reaction in the presence of dicyclohexylcarbodiimide in carboxylic acid.

l?uterung methode

Recrystallise the imide from EtOH/ethyl acetate [Manesis & Goodmen J Org Chem 52 5331 1987]. [Beilstein 21/9 V 498.]

N-Hydroxysuccinimid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


N-Hydroxysuccinimid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 881)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
PRISUN PHARMATECH CO.,LTD
+86-021-54326183-8001 +8618917565227
prisun@prisunpharma.com China 215 58
Chemtour Biotech Co., Ltd
+8617327281506
market@chemtour.com China 1460 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8817 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12795 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5858 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5893 58
airuikechemical co., ltd.
+undefined86-15315557071
sales02@sdzhonghuimaterial.com China 983 58
hebei hongtan Biotechnology Co., Ltd
+86-86-1913198-3935 +8617331935328
sales03@chemcn.cn China 970 58
Hebei Zhuanglai Chemical Trading Co.,Ltd
+8613343047651
admin@zlchemi.com China 3002 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60

6066-82-6(N-Hydroxysuccinimid)Verwandte Suche:


  • N-HYDROXY-2,5-PYRROLIDINEDIONE
  • N-HYDROXYSUCCINIMIDE
  • N-HYDROXYSUCCINIMIDE POLYMER-BOUND
  • NHS N-HYDROXYSUCCINIMIDE,
  • NHS OR HONSU
  • HOSu~1-Hydroxy-2,5-pyrrolidinedione
  • N-Hydroxysuccinimide (HOSu)
  • N-HYDROXYSUCCINIMIDE, 99+%
  • N-HYDROXYSUCCINIMIDE, 98+%
  • Hosu,Nhs(N-Hydroxysuccinimide)
  • 9,10-Bis(Phenthynyl)Anthracene
  • HOSU (N-Hydroxysuccinimide)
  • N-HYDOXYSUCCINIMIDE, NHS
  • HOSU (N-HYDROXYSUCCINIMIDE,NHS)
  • N-Hydroxysuccinimide >97%
  • N-HYDROXYSUCCINIMIDE pure
  • 1-Hydroxy-2,5-pyrrolidinedione, HOSu
  • N-Hydroxysuccinic acid imide
  • Succinimidyl alcohol
  • N-Hydroxysuccinimide [Coupling Reagent for Peptide]
  • O-Hydroxysucc Inimide
  • N-Hydroxysuccinimide,1-Hydroxy-2,5-pyrrolidinedione, HOSu, NHS
  • N-Hydroxysuccinimide≥ 99% (Assay)
  • HOSu Novabiochem
  • 1-hydroxy-5-pyrrolidinedione
  • 5-Pyrrolidinedione,1-hydroxy-2
  • Succinimide, N-hydroxy-
  • AKOS 91864
  • 4-HYDROXY-2,5-PYRROLIDINEDIONE
  • N-HydroxysucciniMide, 98+% 100GR
  • N-HydroxysucciniMide, 98+% 250GR
  • N-HydroxysucciniMide, 98+% 25GR
  • N-Hydroxy-2,5-dioxopyrrolidine
  • N-HYDROXYSUCCINIMIDE FOR SYNTHESIS
  • 1-Hydroxy-2,5-pyrrolidione
  • 1-Hydroxypyrrolidine-2,5-dione, 2,5-Dioxo-1-hydroxypyrrolidine
  • N-HydroxysucciniMide 98%
  • N-HydroxysucciniMide puruM, >=97.0% (T)
  • N - butyl hydroxy diiMide
  • N-Hydroxysuccinimide
  • N- hydroxyl Ji Dingya diamide
  • 1-Hydroxy-2,5-pyrrolidinedione, NHS, N-Hydroxybutanimide, N-гидроксибутанимид
  • N-Hydroxysuccinimide>
  • N-Hydroxysuccinimide [Coupling Reagent for Peptide]>
  • NHS N-Hydroxysuccinimide,98%
  • HOSU 25 G
  • HOSU/NHS
  • N-Hydroxysuccinimide USP/EP/BP
  • NHS
  • N-HYDROXYSUCCINIMDE
  • N-HYDROXYSUCCINAMIDE
  • 1-Hydroxysuccinimide
  • Hydroxysuccinimide
  • 1-HYDROXY-PYRROLIDINE-2,5-DIONE
  • HONSU
  • HOSU
  • 1-HYDROXY-2,5-PYRROLIDINEDIONE
  • 2,5-PYRROLIDINEDIONE, 1-HYDROXY-
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