N-Hydroxysuccinimid
|
|
N-Hydroxysuccinimid Eigenschaften
- Schmelzpunkt:
- 95-98 °C(lit.)
- Siedepunkt:
- 215.33°C (rough estimate)
- Dichte
- 1.4769 (rough estimate)
- Dampfdruck
- 0Pa at 25℃
- Brechungsindex
- 1.4080 (estimate)
- storage temp.
- Store at +2°C to +8°C.
- L?slichkeit
- DMSO (Soluble), Methanol (Slightly)
- pka
- 7.81±0.20(Predicted)
- Aggregatzustand
- Liquid or Solid
- Farbe
- Clear yellow-brown to brown
- PH
- 5-7 (50g/l, H2O, 20℃)
- Wasserl?slichkeit
- SOLUBLE
- Sensitive
- Hygroscopic
- BRN
- 113913
- Stabilit?t:
- Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, strong bases. Protect from moisture.
- InChIKey
- NQTADLQHYWFPDB-UHFFFAOYSA-N
- LogP
- -2.01
- CAS Datenbank
- 6066-82-6(CAS DataBase Reference)
- NIST chemische Informationen
- N-hydroxylsuccinimide(6066-82-6)
- EPA chemische Informationen
- 2,5-Pyrrolidinedione, 1-hydroxy- (6066-82-6)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | Xi | ||
---|---|---|---|
R-S?tze: | 36/37/38 | ||
S-S?tze: | 22-24/25-26-36 | ||
WGK Germany | 3 | ||
Hazard Note | Irritant | ||
TSCA | Yes | ||
HS Code | 29251995 |
Bildanzeige (GHS) | ||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Alarmwort | Achtung | |||||||||||||||||||||
Gefahrenhinweise |
|
|||||||||||||||||||||
Sicherheit |
|
N-Hydroxysuccinimid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.S24/25:Berührung mit den Augen und der Haut vermeiden.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
N-hydroxysuccinimide is a synthetic ingredient used in cosmetics as an ester to soften and condition skin. It's also a reagent, a substance used to trigger a reaction that leads to a new substance, such as peptides and polymers.N-Hydroxysuccinimide is used in cosmetics and beauty products as an ester often seen in eye creams. N-hydroxysuccinimide activates the elimination of blood originated pigments responsible for dark color and inflammation that causes under eye circles. "Infra-orbital shadows are due to the accumulation of hemoglobin and its coloured degradation products - biliverdin, bilirubin and iron - in the dermis and epidermis ... N-hydroxysuccinimide renders the iron soluble for natural elimination" (source).
Chemische Eigenschaften
White to pale yellowVerwenden
N-hydroxysuccinimide (NHS) is often used to assist carbodiimide-mediated peptide coupling by forming an active ester intermediate via condensation of the surface carboxyl group and NHS. The NHS-reactive ester intermediate is susceptible to nucleophilic attack by primary amines and results in the formation of stable amide bonds between the biomaterial surface and the N-terminus of the peptide.Application
N-Hydroxysuccinimide has been used in the synthesis of intermediates such as:N-succinimidyl 3-(di-tert-butylfluorosilyl)benzoate
4-[2,2-bis[(p-tolylsulfonyl)-methyl] acetyl]benzoic acid-NHS ester
N-succinimidyl 3-iodobenzoate
It has also been used in a protocol for the surface modification of microchannels of a microfluidic-integrated surface plasmon resonance (SPR) platform for the detection and quantification of bacterial pathogens.
Additive used in the carbodiimide method for improved amidations and peptide couplings.
N-Hydroxysuccinimide can be used in the synthesis of N-hydroxysuccinimide ester via dehydration reaction in the presence of dicyclohexylcarbodiimide in carboxylic acid.
l?uterung methode
Recrystallise the imide from EtOH/ethyl acetate [Manesis & Goodmen J Org Chem 52 5331 1987]. [Beilstein 21/9 V 498.]N-Hydroxysuccinimid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Bernsteinsureanhydrid
Hydroxylammoniumchlorid
NSC81536
estradiol-3-sulfate
1-Pyrrolidinecarboxylic acid, 2,5-dioxo-, 1,1-dimethylethyl ester
1-Hydroxypiperidine-2,6-dione
N-Hydroxysuccinimidyl-(4-azido-benzoat)
Di(succinimido)carbonat
N-(3-aminopropyl)benzamide
BZ-OSU
(Hydrazinocarbonylmethyl)trimethylammoniumchlorid
N-Succinimidyl 3-maleimidopropionate
2-Methylbutylamin
Downstream Produkte
N-Hydroxysuccinimid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 884)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
PRISUN PHARMATECH CO.,LTD | +86-021-54326183-8001 +8618917565227 |
prisun@prisunpharma.com | China | 215 | 58 |
Chemtour Biotech Co., Ltd | +8617327281506 |
market@chemtour.com | China | 1460 | 58 |
Hebei Weibang Biotechnology Co., Ltd | +8615531157085 |
abby@weibangbio.com | China | 8806 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12834 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5857 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5889 | 58 |
Hebei Weibang Biotechnology Co., Ltd | +8617732866630 |
bess@weibangbio.com | China | 18151 | 58 |
airuikechemical co., ltd. | +86-18353166132 +86-18353166132 |
sales02@airuikechemical.com | China | 983 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 |
sales03@chemcn.cn | China | 970 | 58 |
Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 |
admin@zlchemi.com | China | 3002 | 58 |
6066-82-6(N-Hydroxysuccinimid)Verwandte Suche:
1,1'-(Methylendi-p-phenylen)bismaleimid
Ethylsuccinylsuccinat
N-Chlorsuccinimid
3,6-Bis[(4-chlor-2-phosphonophenyl)azo]-4,5-dihydroxynaphthalin-2,7-disulfonsure
1-Iodpyrrolidin-2,5-dion
N-Bromsuccinimid
Succinimid
Dispersing agent 155
Phthalimid
N-Methyldiallylamin
2-Oxoimidazolidin-1-carbonylchlorid
2-Anilinoethanol
tert-Butyl-N-hydroxycarbamat
N-Octadecylstearamid
Benzylchlorid
Malonyldichlorid
2,6-Dichlorpyrimidin-4-amin
Benzyl(methyl)amin
- N-HYDROXY-2,5-PYRROLIDINEDIONE
- N-HYDROXYSUCCINIMIDE
- N-HYDROXYSUCCINIMIDE POLYMER-BOUND
- NHS N-HYDROXYSUCCINIMIDE,
- NHS OR HONSU
- HOSu~1-Hydroxy-2,5-pyrrolidinedione
- N-Hydroxysuccinimide (HOSu)
- N-HYDROXYSUCCINIMIDE, 99+%
- N-HYDROXYSUCCINIMIDE, 98+%
- Hosu,Nhs(N-Hydroxysuccinimide)
- 9,10-Bis(Phenthynyl)Anthracene
- HOSU (N-Hydroxysuccinimide)
- N-HYDOXYSUCCINIMIDE, NHS
- HOSU (N-HYDROXYSUCCINIMIDE,NHS)
- N-Hydroxysuccinimide >97%
- N-HYDROXYSUCCINIMIDE pure
- 1-Hydroxy-2,5-pyrrolidinedione, HOSu
- N-Hydroxysuccinic acid imide
- Succinimidyl alcohol
- N-Hydroxysuccinimide [Coupling Reagent for Peptide]
- O-Hydroxysucc Inimide
- N-Hydroxysuccinimide,1-Hydroxy-2,5-pyrrolidinedione, HOSu, NHS
- N-Hydroxysuccinimide≥ 99% (Assay)
- HOSu Novabiochem
- 1-hydroxy-5-pyrrolidinedione
- 5-Pyrrolidinedione,1-hydroxy-2
- Succinimide, N-hydroxy-
- AKOS 91864
- 4-HYDROXY-2,5-PYRROLIDINEDIONE
- N-HydroxysucciniMide, 98+% 100GR
- N-HydroxysucciniMide, 98+% 250GR
- N-HydroxysucciniMide, 98+% 25GR
- N-Hydroxy-2,5-dioxopyrrolidine
- N-HYDROXYSUCCINIMIDE FOR SYNTHESIS
- 1-Hydroxy-2,5-pyrrolidione
- 1-Hydroxypyrrolidine-2,5-dione, 2,5-Dioxo-1-hydroxypyrrolidine
- N-HydroxysucciniMide 98%
- N-HydroxysucciniMide puruM, >=97.0% (T)
- N - butyl hydroxy diiMide
- N-Hydroxysuccinimide
- N- hydroxyl Ji Dingya diamide
- 1-Hydroxy-2,5-pyrrolidinedione, NHS, N-Hydroxybutanimide, N-гидроксибутанимид
- N-Hydroxysuccinimide>
- N-Hydroxysuccinimide [Coupling Reagent for Peptide]>
- NHS N-Hydroxysuccinimide,98%
- HOSU 25 G
- HOSU/NHS
- N-Hydroxysuccinimide USP/EP/BP
- NHS
- N-HYDROXYSUCCINIMDE
- N-HYDROXYSUCCINAMIDE
- 1-Hydroxysuccinimide
- Hydroxysuccinimide
- 1-HYDROXY-PYRROLIDINE-2,5-DIONE
- HONSU
- HOSU
- 1-HYDROXY-2,5-PYRROLIDINEDIONE
- 2,5-PYRROLIDINEDIONE, 1-HYDROXY-