Paromomycinsulfate
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Paromomycinsulfate Eigenschaften
- Schmelzpunkt:
- 145 °C (decomp)
- alpha
- D25 +50.5° (c = 1.5 in water pH 6)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- L?slichkeit
- H2O: 50 mg/mL store stock solution at 2-8°C. Stable at 37°C for 5 days.
- Aggregatzustand
- powder
- Farbe
- White to Off-White
- Wasserl?slichkeit
- Soluble in water
- Merck
- 14,7041
- BRN
- 5715182
- Stabilit?t:
- Hygroscopic
- InChIKey
- LJRDOKAZOAKLDU-UDXJMMFXSA-N
- CAS Datenbank
- 1263-89-4
- EPA chemische Informationen
- Paromomycin sulfate (1263-89-4)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | Xi | ||
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R-S?tze: | 23/24/25-36/38-39/23/24/25-61-36/37/38 | ||
S-S?tze: | 26-36/37-45-38-36 | ||
WGK Germany | 2 | ||
RTECS-Nr. | WK2320000 | ||
HS Code | 2941901010 | ||
Toxizit?t | LD50 in mice (mg/kg): ~15,000 orally; 700 s.c.; 110 i.v. (Di Marco, Bertazzoli) |
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Paromomycinsulfate Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.R36/38:Reizt die Augen und die Haut.
R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
R61:Kann das Kind im Mutterleib sch?digen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S38:Bei unzureichender Belüftung Atemschutzger?t anlegen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Paromomycin was found in the culture broth of Streptomyces rimosus forma paromomycinus by Parke Davis & Co. in 1959. In the same year it was found in the culture broth of S. Crestomyceticus by Farmitalia and named amminosidin. Paromomycin is related structurally to neomycin, but it has a hydroxyl group at the 6 position, whereas neomycin has an amino group. Its antibacterial activity is weaker than that of neomycin, but its toxicity is much less. Paromomycin is used by intramuscular injection for therapy of respiratory, urinary, and surgical infections and by oral administration to treat dysentery and salmonellosis.Chemische Eigenschaften
PAROMOMYCIN SULFATE is White to Off-White SolidVerwenden
PAROMOMYCIN SULFATE is an aminogycoside antibiotic designed to fight intestinal infections such as cryptosporidiosis, amoebiasis, and leishmaniasis. Its antiprotozoal activity makes it an effecive histomonostatic feed addit ive in turkey poults experimentally infected with Histomonas meleagridis.Definition
ChEBI: An aminoglycoside sulfate salt resulting from the treatment of paromomycin with sulfuric acid. A broad-spectrum antibiotic, it is used for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoa infections. It is also used as a therapeutic against visceral leishmaniasis.Allgemeine Beschreibung
Chemical structure: aminoglycosideClinical Use
The isolation of paromomycin (Humatin) was reported in1956 from a fermentation with a Streptomyces sp. (PD04998), a strain said to resemble S. rimosus very closely.The parent organism had been obtained from soil samplescollected in Colombia. Paromomycin, however, moreclosely resembles neomycin and streptomycin in antibioticactivity than it does oxytetracycline, the antibiotic obtainedfrom S. rimosus.Paromomycin has broad-spectrum antibacterial activityand has been used for the treatment of GI infections causedby Salmonella and Shigella spp., and enteropathogenic E.coli. Currently, however, its use is restricted largely to thetreatment of intestinal amebiasis. Paromomycin is soluble inwater and stable to heat over a wide pH range.
Sicherheitsprofil
Poison by intravenous,subcutaneous, and intramuscular routes. Mildly toxic byingestion. Mutation data reported. When heated to decomposition it emits very toxic fumesof SOx and NOx.l?uterung methode
Purify it by dissolving it in H2O (0.5g/10mL) and adding excess EtOH, filter or collect and wash with EtOH, then Et2O by centrifugation, and dry it in vacuo. An aqueous solution is stable at 37o for a week but longer at 0-5o. The free base [7542-37-2] is a white amorphous powder which should be stored under N2 because it is strongly basic and can absorb CO2 from the atmosphere. It is soluble in MeOH (less soluble in EtOH) and has [] D 25 +65o (c 1.5, MeOH). It is an antimicrobial against Gram +ve and Gram –ve bacteria and is antiamoebic. It inhibits initiation and peptide elongation during protein synthesis. [Haskell et al. J Am Chem Soc 8 1 , 3480, 3482 1959, Hichens & Rinehart J Am Chem Soc 85 1547 1963, Beilstein 18 III/IV 7534.]Paromomycinsulfate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Paromomycinsulfate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 356)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Hebei Weibang Biotechnology Co., Ltd | +8615531157085 |
abby@weibangbio.com | China | 8806 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 |
1022@dideu.com | China | 3882 | 58 |
Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12831 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531153977 |
allison@yan-xi.com | China | 5856 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5889 | 58 |
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 +86-18600796368 |
sales@sjar-tech.com | China | 484 | 58 |
Hangzhou FandaChem Co.,Ltd. | +8615858145714 |
FandaChem@Gmail.com | China | 8771 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29879 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28172 | 58 |
Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8618959220845 |
sales@amoychem.com | China | 6383 | 58 |
1263-89-4(Paromomycinsulfate)Verwandte Suche:
o-[N-(5-Nitrothiazol-2-yl)carbamoyl]phenylacetat
Spiramycin
Ribostamycinsulfat
Spectinomycindihydrochlorid
Bis(2-ammonio-2-desoxy-D-glucose)sulfat
Paromomycinsulfate
Paromomycin
Methyl-β-D-ribofuranosid
- PAROMOMYCIN SULFATE
- aminosidinesulfate
- aminosidinesulphate
- aminosidinsulfate
- fi5853
- gabbroral
- D-Streptamine, O-2,6-diamino-2,6-dideoxy-b-L-idopyranosyl-(13)-O-b-D-ribofuranosyl-(15)-O-[2-amino-2-deoxy-a-D-glucopyranosyl-(14)]-2-deoxy-, sulfate (salt) (8CI)
- D-Streptamine, O-2-amino-2-deoxy-a-D-glucopyranosyl-(14)-O-[O-2,6-diamino-2,6-dideoxy-b-L-idopyranosyl-(13)-b-D-ribofuranosyl-(15)]-2-deoxy-, sulfate (salt) (9CI)
- Farmiglucin
- Farminosidin
- Humagel
- Paramicina
- Pargonyl
- Paricina
- Sinosid
- Paromomycin Sufate
- D00868
- Humatin (tn)
- Paromomycin sulfate (jan/usp)
- Paromomycin sulfate ,98%
- Paromomycin Sulfate (125 mg)
- PayoMoMycin Sulfate
- O-2,6-DiaMino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-aMino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-D-StreptaMine Sulfate
- humycinsulfate
- streptamine,o-2,6-diamino-2,6-dideoxy-beta-l-idopyranosyl-(1-3)-o-beta-d-ribof
- paromomycin sulfate cell culture tested
- paromomycin sulfate plant cell*culture tested
- paromomycin sulphates
- D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:1)
- Barone sulfate kanamycin Solution, 100ppm
- PAROMOMYCIN SULFATE CELL CULTURE REAGENT 97+%
- PAROMOMYCIN SULFATE USP 97+%
- Paramomycinsulfate
- 1600 Antibiotic
- Aminosidin sulphate
- Aminoxidin
- O-2-AMino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diaMino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-D-streptaMine Sulfate
- Paromomycin sulphate solution,1000ppm solution
- Paromomycin sulphate solution,100ppm
- Paromomycin Sulfate - CAS 1263-89-4 - Calbiochem
- Framycetin EP Impurity E
- Paromomycin Sulfate >
- PAROMOMYCIN SULFATE USP/EP/BP
- Paromomycin Sulfater
- Framycetin sulfate EP Impurity E
- (2S,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-(((2R,3S,4R,5S)-5-(((1R,2R,3S,5R,6S)-3,5-diamino-2-(((2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-6-hydroxycyclohexyl)oxy)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)tetrahydro-2H-pyran-3,4-diol sulfate(1:x)
- Paromomycin Sulfate (PRM)
- Paromomycin Sulfate (1500003)
- O - 2, 6 - Diamino - 2, 6 - dideoxy - b - L - idopyranosyl - (1,3) - O - b - D - ribofuranosyl - (1,5) - O - [2 - amino - 2 - deoxy - a - D - glucopyranosyl - (1,4) ] - 2 - deoxy - streptamine sulfate
- humatin
- sulf
- Neomycin Sulfate EP Impurity E
- PAROMOMYCIN SULPHATE
- PAROMOMYCIN SULFATE SALT
- NEOMYCIN E
- Paromomycine sulphate
- Baromycin sulfate
- Paromomycin Sulfate, ≥ 94.0%