Nepicastat hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Nepicastat is an inhibitor of dopamine β-hydroxylase (DBH; IC₅₀ = 9 nM for the purified human enzyme). It is selective for DBH over a panel of 12 enzymes and 13 neurotransmitter receptors (IC₅₀s or K_is = >10 μM). Nepicastat dose-dependently reduces norepinephrine content and increases dopamine content in the mesenteric artery, left ventricle, and cerebral cortex in spontaneously hypertensive rats, as well as in the renal artery, left ventricle, and cerebral cortex in beagle dogs. It attenuates increases in diastolic blood pressure and heart rate induced by preganglionic sympathetic nerve stimulation in pithed spontaneously hypertensive rats when administered orally at doses of 10 and 30 mg/kg. Nepicatstat (50 mg/kg) reduces the progressive ratio response for cocaine, but not food or sucrose pellets, in rats. It also reduces reinstatement of cocaine-seeking behavior induced by cues, yohimbine , or foot-shock in rats.

Verwenden

Nepicastat Hydrochloride is a potent and selective dopamine β-hydrolase inhibitor. Used in cardiovascular treatment where deficiencies in ventricles results in heart failure.

Nepicastat hydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Nepicastat hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29811	58
Wuhan Monad Medicine Tech Co.,LTD	02768782018 18771942761	sales01@whmonad.com	CHINA	979	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Apeloa Pharmaceutical Co., Ltd.	+86-0571-87635730 +8615858229168	chem1022@hengdian-group.com	China	1478	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22784	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9911	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19987	58
Alfa Chemistry		Info@alfa-chemistry.com	United States	24072	58

170151-24-3()Verwandte Suche:

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• NEPICASTAT HYDROCHLORIDE
• Nepicastat HCl (SYN-117),Nepicastat hydrochloride,
• Nepicastat (SYN-117) HCl
• (S)-5-(AMinoMethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1H-iMidazole-2(3H)-thione hydrochloride
• Nepicastat (SYN117)HCI
• RS 25560-197 Nepicastat hydrochloride
• 5-(Aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro-2H-imidazole-2-thione hydrochloride
• 5-(Aminomethyl)-1-[5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2(S)-yl]-2,3-dihydro-1H-imidazole-2-thione hydrochloride
• Nepicastat HCl, >=99%
• (S)-5-(Aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1H-imidazole-2(3H)-thio
• Nepicastat HCl (SYN-117)
• 4-(aminomethyl)-3-[(2S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-1H-imidazole-2-thione
• Nepicastat (SYN-117) hydrochloride
• Nepicastat Hydrochloride (SYN-117 hydrochloride
• RS-25560-197 hydrochloride)
• SYN-117 HCl
• SYN-117 hydrochloride
• SYN-117 HYDROCHLORIDE;RS-25560-197 HYDROCHLORIDE
• Nepicastat hydrochloride USP/EP/BP
• 4-(aminomethyl)-3-[(2S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-1H-imidazole-2-thione,hydrochloride
• 2H-Imidazole-2-thione,5-(aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro-,hydrochloride (1:1)
• (S)-5-(Aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1,3-dihydro-2H-imidazole-2-thione hydrochloride
• Dopamine beta-monooxygenase,Dopamine beta-hydroxylase,Dopamine β-monooxygenase,Nepicastat hydrochloride,Nepicastat,SYN117,SYN-117,Dopamine β-hydroxylase,Inhibitor,SYN 117,inhibit
• 170151-24-3
• 70151-24-3
• C14H15F2N3SHCl
• C14H16ClF2N3S
• C14H15F2N3SClH
• Inhibitors
• Inhibitor