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Pyridoxal 5’-Phosphate

Pyridoxal 5’-Phosphate Struktur
853645-22-4
CAS-Nr.
853645-22-4
Englisch Name:
Pyridoxal 5’-Phosphate
Synonyma:
Pyridoxal 5’3-Hydroxy-2-methyl-5;-phosphate (hydrate);PYRIDOXAL-5-PHOSPHATE;pyridoxa 5' phosphate;PYRIDOXAL-5'-PHOSPHATE;Pyridoxaol-5-phosphate;rubber accelerator MBTS;Pyridoxal-[d3] Phosphate;Pyridoxal 5'-phosphate hydrate
CBNumber:
CB22131140
Summenformel:
C8H10NO6P
Molgewicht:
247.14
MOL-Datei:
853645-22-4.mol

Pyridoxal 5’-Phosphate Eigenschaften

Schmelzpunkt:
140-143 ºC
storage temp. 
-20°C
L?slichkeit
DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly)
pka
pKa 8.69(H2O t = 25 I = 0.15)(Approximate)
Aggregatzustand
powder
Farbe
White to Pale Yellow
Geruch (Odor)
Odorless
BRN 
234749
Stabilit?t:
Hygroscopic
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
WGK Germany  3
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Pyridoxal 5’-Phosphate Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Enzyme cofactor.Normal coenzyme form of Vitamin B6

Allgemeine Beschreibung

Pyridoxal 5′-phosphate (PLP) is synthesized in a multiple-step process. The two pathways inlcude pyridoxal phosphate biosynthetic protein (PdxA)- pyridoxine-5′-phosphate synthase (PdxJ) pathway and the pyridoxal 5′-phosphate synthase subunit PDX1/PDX2 pathway. It is the active form of pyridoxine.

Biochem/physiol Actions

Pyridoxal 5′-phosphate (PLP) aids in carbohydrate and fat metabolism by serving as a cofactor. It is majorly responsible for catalyzing the enzymatic reactions involved in sphingolipid synthesis and neurotransmitter (dopamine and serotonin) synthesis. PLP is used in the studies of PLP-dependent enzyme active sites. PLP is also a cofactor for a wide range of enzymes including mitochondrial 5-Aminolevulinic acid synthase (ALAS) cysteine desulfurase, cystathionine γ-synthase (CGS), ornithine 4,5-aminomutase (OAM), and D-serine dehydratase.

Synthese

A process for the synthesis ofpyridoxal5' -phosphate, comprising the steps of:
a) adding phenetidine into pyridoxal solution, and reacting to generate pyridoxal Schiff base;
b) adding pyridoxal Schiff base into ionic liquid, and stirring until the pyridoxal Schiff base is fully dissolved to obtain an ion mixed solution; adding pyridoxal Schiff base into ionic liquid, stirring at 35-45 ℃, and cooling the obtained ionic mixed solution to room temperature after the pyridoxal Schiff base is completely dissolved;
c) adding polyphosphoric acid into the ion mixed solution in which the pyridoxal Schiff base is dissolved, stirring for reaction, cooling after the reaction is finished, and separating out solids from the ion mixed solution; filtering solid particles separated out from the ion mixed solution, wherein the solid obtained by filtering is pyridoxal 5' -phosphate Schiff base, and the obtained liquid is phosphorus-containing ionic liquid; the weight ratio of pyridoxal Schiff base dissolved in the ion mixed solution to the polyphosphoric acid is within the range of 1:1-1:3, the reaction time is within the range of 8-12h, the reaction temperature is within the range of 25-40 ℃, and the temperature is reduced to 10 ℃ after the reaction is finished; the phosphorus-containing ionic liquid obtained by filtering can be recycled;
d) carrying out hydrolysis purification reaction on the pyridoxal 5 '-phosphate Schiff base obtained in the step c) to obtain a final product pyridoxal 5' -phosphate.

Pyridoxal 5’-Phosphate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Pyridoxal 5’-Phosphate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 108)Lieferanten
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853645-22-4()Verwandte Suche:


  • Phosphoric acid 2-methyl-3-hydroxy-4-formylpyridine-5-yl ester
  • Pyridoxaol-5-phosphate
  • 3-Hydroxy-2-methyl-5
  • (4-ForMyl-5-hydroxy-6-Methylpyridin-3-yl)Methyl dihydrogen phosphate
  • PYRIDOXAL 5'-PHOSPHATE HYDRATE POWDE
  • PYRIDOXAL 5'-PHOSPHATE HYDRATE, >=98
  • (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate hydrate(1:x)
  • PYRIDOXAL-5'-PHOSPHATE
  • PYRIDOXAL-5-PHOSPHATE
  • 3-Hydroxy-2-methyl-5-([phosphonooxy]methyl)-4-pyridinecarboxaldehyde
  • 3-Hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde
  • 5-(Phosphonooxy)-3-hydroxy-2-methylpyridine-4-carbaldehyde
  • Pyridoxal-5-phosphateQ: What is Pyridoxal-5-phosphate Q: What is the CAS Number of Pyridoxal-5-phosphate Q: What is the storage condition of Pyridoxal-5-phosphate Q: What are the applications of Pyridoxal-5-phosphate
  • Pyridoxal 5’-Phosphate ISO 9001:2015 REACH
  • Pyridoxal-[d3] Phosphate(Vitamin B6-[d3])
  • Pyridoxal 5'-phosphate hydrate powder, BioReagent, suitable for cell culture
  • -phosphate (hydrate)
  • Pyridoxal 5&rsquo
  • Pyridoxal-[d3] Phosphate
  • (4-formyl-5-hydroxy-6-methyl-3-pyridinyl)methyl dihydrogen phosphate
  • rubber accelerator MBTS
  • pyridoxa 5' phosphate
  • Pyridoxal 5'-phosphate hydrate
  • 853645-22-4
  • Chemical Synthesis
  • Cofactors
  • Enzymes
  • Inhibitors
  • Nutrition Research
  • Organic Building Blocks
  • Vitamins
  • Other Cofactors
  • Vitamin B
  • Vitamin B6
  • Aldehydes
  • and Substrates
  • Biochemicals and Reagents
  • Building Blocks
  • C8
  • Carbonyl Compounds
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