FLAVOPIRIDOL HYDROCHLORIDE
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- CAS-Nr.
- 131740-09-5
- Englisch Name:
- FLAVOPIRIDOL HYDROCHLORIDE
- Synonyma:
- HL 275;CS-976;L-86-8276;NSC 649890;MDL 107826A;Alvocidib HCL;NSC 649890 HCl;Flavopiridol HC;Flavopiridol HCI;FLAVOPIRIDOL HCL
- CBNumber:
- CB1972179
- Summenformel:
- C21H21Cl2NO5
- Molgewicht:
- 438.3
- MOL-Datei:
- 131740-09-5.mol
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FLAVOPIRIDOL HYDROCHLORIDE Eigenschaften
- Schmelzpunkt:
- 169.5-170°C
- alpha
- 24D -1.73 to -3.9°
- storage temp.
- 2-8°C
- L?slichkeit
- H2O: ~2mg/mL
- pka
- 5.68 ± 0.06(at 25℃)
- Aggregatzustand
- powder
- Farbe
- white to light brown
- Wasserl?slichkeit
- H2O: ~2mg/mL
DMSO: >5mg/mL
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month
- CAS Datenbank
- 131740-09-5
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
DJ2978830 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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FLAVOPIRIDOL HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
Beschreibung
Flavopiridol is an orally bioavailable inhibitor of cyclin dependent kinases (IC
50s = ~100, ~100, ~100, and 300 nM for Cdk1, Cdk2, Cdk4, and Cdk7, respectively). It also inhibits TEFb, a complex composed of Cdk9 and cyclin T1, with a K
i value of 3 nM. Flavopiridol inhibits transcription of a CMV promoter in HeLa nuclear extract (IC
50 = 34 nM), Tat-stimulated transcription of an HIV-1 promotor (IC
50 = 7 nM), and HIV-1 replication in HEK239T cells (IC
50 = <10 nM).
In vivo, flavopiridol (5 mg/kg, i.p.) induces apoptosis and cyclin D1 depletion and delays tumor growth in an HN-12 head and neck carcinoma mouse xenograft model. It also suppresses synovial hyperplasia and joint destruction in a mouse model of collagen-induced arthritis.
Chemische Eigenschaften
Yellow Powder
Verwenden
Flavopiridol hydrochloride hydrate has been used:
- as a cyclin-dependent kinase 9 (CDK9) inhibitor to study its effects on histone H3 methylation at lysine 36 (H3K36) and deactivation of transcription in porcine fetal fibroblasts
- as an RNA polymerase inhibitor to study its effects on hepatic cells
- as RNA transcription inhibitor to study its effects on euchromatin coarsening in zebrafish embryo
Definition
ChEBI: A hydrochloride salt resulting from the formal reaction of equimolar amounts of alvocidib and hydrogen chloride. A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic p
aque formation.
FLAVOPIRIDOL HYDROCHLORIDE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
FLAVOPIRIDOL HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 155)Lieferanten
131740-09-5()Verwandte Suche:
- Flavopiridol (Alvocidib)hcl
- Flavopiridol HCI
- L-86-8276
- 2-(2-chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one hydrochloride
- NSC 649890 HCl
- (-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride Flavopiridol hydrochloride
- Flavopiridol hydrochloride
(-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride
- Flavopiridol hydrochloride, >=98%
- Alvocidib HCL
- Flavopiridol (Alvocidib) hydrochloride
- Flavopiridol hydrochloride hydrate
- FLAVOPIRIDOL HYDROCHLORIDE
- FLAVOPIRIDOL HCL
- Alvocidib Hydrochloride
- HL 275
- MDL 107826A
- NSC 649890
- rel-(-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one Hydrochloride
- L-86-8276, NSC-649890, (-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3s,4r)-3-hydroxy-1-methyl-4-piperidinyl]-4h-1-benzopyran-4-one hydrochloride
- (-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride
- 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-, hydrochloride, (-)-cis-
- 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3R,4S)-3-hydroxy- 1-methyl-4-piperidinyl]-, hydrochloride, rel-
- CS-976
- FLAVOPIRIDOL HYDROCHLORIDE USP/EP/BP
- 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one,hydrochloride
- NSC-649890 hydrochloride
- HL 275; NSC 649890; MDL 107826A; FLAVOPIRIDOL HCL; ALVOCIDIB HYDROCHLORIDE
- Flavopiridol HC
- Flavopiridol (L86-8275) HCl
- Alvocidib Hydrochloride|||NSC 649890|||MDL 107826A|||HL 275|||FLAVOPIRIDOL HCL|||NSC 649890 HCl
- Flavopiridol hydrochloride, 10 mM in DMSO
- 131740-09-5
- C21H20ClNO5HCl
- C21H21Cl2NO5
- Inhibitors
- Aromatics
- Chiral Reagents
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
