3-Maleimidopropionic acid
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- CAS-Nr.
- 7423-55-4
- Englisch Name:
- 3-Maleimidopropionic acid
- Synonyma:
- 3-(2,5-DIOXO-2,5-DIHYDRO-1H-PYRROL-1-YL)PROPANOIC ACID;BMPA;3-(2,5-DIOXO-2,5-DIHYDRO-PYRROL-1-YL)-PROPIONIC ACID;MPA-OH;3-Maleimidopropionic;AKOS BC-0729;Mal-(CH2)2-COOH;n-maleoyl-β-alanine;MALEOYL-BETA-ALA-OH;RARECHEM AL CD 0912
- CBNumber:
- CB1371466
- Summenformel:
- C7H7NO4
- Molgewicht:
- 169.13
- MOL-Datei:
- 7423-55-4.mol
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3-Maleimidopropionic acid Eigenschaften
- Schmelzpunkt:
- 103-106 °C (lit.)
- Siedepunkt:
- 382.5±25.0 °C(Predicted)
- Dichte
- 1.473±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- pka
- 4.18±0.10(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White
- Wasserl?slichkeit
- Soluble in methanol, dimethyl formamide, alcohol and dimethyl sulfoxide. Slightly soluble in water.
- Sensitive
- Moisture Sensitive
- BRN
- 1528952
- InChIKey
- IUTPJBLLJJNPAJ-UHFFFAOYSA-N
- CAS Datenbank
- 7423-55-4(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
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| R-S?tze: |
36/37/38 |
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| S-S?tze: |
26-36 |
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| WGK Germany |
3 |
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| F |
10-21 |
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| HS Code |
29252900 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P271 |
Nur im Freien oder in gut belüfteten R?umen verwenden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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3-Maleimidopropionic acid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White to Pale Yellow Solid
Verwenden
3-Maleimidopropionic acid is a sulfhydryl reactive heterobifunctional crosslinking reagent.
Application
3-Maleimidopropionic acid (3MP) is a molecule that can be used for the treatment of cancer. 3MP has been shown to inhibit the growth of tumor cells and induce apoptosis. It also inhibits the production of reactive oxygen species, which are produced by cancer cells as a result of chemotherapy. 3MP has potent inhibitory activity against bacterial organisms such as methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium perfringens and antiviral properties against HIV infection. This molecule can also be used in conjunction with monoclonal antibodies or other immunotherapy techniques to improve their efficacy.
Allgemeine Beschreibung
N-Maleoyl-β-alanine (3-maleimidopropanoic acid) is an aliphatic
N-substituted maleimide. It is one of the component of the stabilizing solution for EC145 (a folate-targeted vinca alkaloid conjugate) used in rodent pharmacokinetic studies.
Synthese
An acetic acid solution of maleic anhydride (5.00 g in 50 mL) was added dropwise to an acetic acid solution of β-alanine (4.54 g in 50 mL). The mixture was stirred at room temperature. After 3 h, AcOH (70 mL ) was added and the temperature was raised to 115 °C under stirred overnight. After 1 hour, an orange oil was obtained. The solvent excess was removed under reduced pressure and the product was washed with toluene (3 × 30 mL). The product was then purified by flash chromatography using a silica column (DCM/ethylacetate 9:1) to obtain the white solid 3-Maleimidopropionic acid.
3-Maleimidopropionic acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-Maleimidopropionic acid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 315)Lieferanten
7423-55-4()Verwandte Suche:
- N-(2-CARBOXYETHYL)MALEIMIDE
- N-BETA-MALEIMIDOPROPIONIC ACID
- N-MALEOYL-BETA-ALANINE
- RARECHEM AL CD 0912
- AKOS BC-0729
- 3-MALEIMIDOPROPIONIC ACID
- MALEOYL-BETA-ALA-OH
- BETA-MALEIMIDOPROPIONIC ACID
- B-MALEIMIDOPROPIONIC ACID
- 3-Maleinimidopropionicacid
- n-maleoyl-β-alanine
- 3-MALEIMIDOPROPIONOIC ACID DIHYDRATE
- 3-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-prop
- 3-Maleimidopropionic acid, N-(2-Carboxyethyl)maleimide
- N-Maleoyl-β-ananine
- 3-Maleimidopropionic acid ,98%
- N-Maleoyl-β-alanine,3-Maleimidopropionic acid, N-(2-Carboxyethyl)maleimide
- Mal-(CH2)2-COOH (MPA)
- N-(2-Carboxyethyl)maleimide, 3-Maleimidopropionic acid
- 2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-propanoic Acid
- Maleoyl-bAla-OH, MPA-OH, 3-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-propionic acid
- 3-MaleiMidopropioniccid (BMPA)
- Mal-(CH2)2-COOH
- MPA 3-Maleimidopropionic acid
- 3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propa
- N-Maleoyl-beta-alanine 97%
- 3-maleimidopropropionic acid
- 3-(2,5-Dioxo-2,5-dihydropyrrol-1-yl)propanoic acid
- 3-(2,5-Dioxopyrrol-1-yl)propanoic acid
- 3-Maleimidopropionic acid(MPA)
- Maleimide-(CH2)2-COOH
- 3-MaleimidopropionicAcid>
- 1H-Pyrrole-1-propanoic acid, 2,5-dihydro-2,5-dioxo-
- 3-(2,5-DIOXO-2,5-DIHYDRO-PYRROL-1-YL)-PROPIONIC ACID
- 3-(2,5-DIOXO-2,5-DIHYDRO-1H-PYRROL-1-YL)PROPANOIC ACID
- BMPA
- MPA-OH
- 3-Maleimidopropionic
- [MAL-PA] 3-Maleimide propionic acid
- 3-maleimide propionic acid
- N-Maleoyl-β-alanine
- 3-Maleimidopropionic acid dihydrate
- 7423-55-4
- Organic Building Blocks
- Cyclic Imides
- Building Blocks
- Carbonyl Compounds
- Maleimide Derivatives
- N-Substituted Maleimides
- N-Substituted Maleimides, Succinimides & Phthalimides
- Cross Linking Reagents
- MTS & Sulfhydryl Active Reagents
- Heterobifunctional Crosslinker
- Building Blocks
- Carbonyl Compounds
- Chemical Synthesis
- Cyclic Imides
- Organic Building Blocks
