Amifostine
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- CAS-Nr.
- 20537-88-6
- Englisch Name:
- Amifostine
- Synonyma:
- Ethyol;γphos;sapep;Ethyo;WR2721;apaetp;CS-271;wr2721c;Ethiotas;ym-08310
- CBNumber:
- CB1316377
- Summenformel:
- C5H15N2O3PS
- Molgewicht:
- 214.22
- MOL-Datei:
- 20537-88-6.mol
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Amifostine Eigenschaften
- Schmelzpunkt:
- 160-1610C
- Siedepunkt:
- 441.7±51.0 °C(Predicted)
- Dichte
- 1.367±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- Soluble in Water.
- Aggregatzustand
- powder
- pka
- 1.28±0.10(Predicted)
- Farbe
- White
- Wasserl?slichkeit
- Soluble to 100 mM in water
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
- CAS Datenbank
- 20537-88-6(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P330 |
Mund ausspülen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Amifostine Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Amifostine, an organic thiophosphate, was introduced for the reduction
of cisplatin-induced renal toxicity in patients with advanced ovarian cancer. It is also a
radio-protective agent. Amifostine is a prodrug which is rapidly dephosphorylated,
preferentially in non-tumor tissues to the active thiol. This agent binds to
chemotherapeutic drugs and free radicals released by radiotherapy. The protective
effect of amifostine was observed in a wide range of normal organs including bone
marrow and gastrointestinal mucosa without interfering with the anti-tumor effect of
chemohadiotherapy, indicating an increased therapeutic index for existing cancer
treatment. Amifostine is also being evaluated as a cytoprotective in other types of
tumors including lung, breast, head and neck cancers. It was reported to be a potent
mucolytic with potential in cystic fibrosis.
Chemische Eigenschaften
White Solid
Verwenden
It is a thiophosphate derivative of cysteamine; provides normal cells with selective protection against the toxic effects of cancer chemotherapy and radiation treatment
Definition
ChEBI: An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.
Sicherheitsprofil
Poison by intravenous,intramuscular, and intraperitoneal routes. Moderately toxicby ingestion. An experimental teratogen. Otherexperimental reproductive effects. Mutation data reported. When heated todecomposition it emits very toxic fumes of SOx, PO
Amifostine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Amifostine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 232)Lieferanten
20537-88-6()Verwandte Suche:
- γphos
- Fosteamine
- 2-(3-Aminopropyl)aminoethyl phosphorothioate, WR2721
- Ethiotas
- S-2-[(3-Aminopropyl)amino]ethanethiol dihydrogen phosphate ester
- Amifostine,2-(3-Aminopropyl)aminoethyl phosphorothioate, WR2721
- AMifostine anhydrous
- AMifostine(Ethiofos)
- AMIFOSTIN
- AMINOPROPYL AMINOETHYLTHIOPHOSPHATE
- AaMifostine
- 2-(3-aminopropylamino)ethylsulfanylphosphonic acid
- WR2721
- 2-((3-aminopropyl)amino)-ethanethiodihydrogenphosphate(ester)
- 2-[3-AMINOPROPYL]AMINOETHYL PHOSPHOROTHIOATE
- S-2-(3-AMINOPROPYLAMINO)ETHYL O,O-DIHYDROGEN PHOSPHOROTHIOATE
- sapep
- s-omega-(3-aminopropylamino)ethyldihydrogenphosphorothioate
- wr2721c
- ym-08310
- 2-[(3-Aminopropyl)-amino]ethanethiol Dihydrogen Phosphate
- CSC-296961
- Ethyo
- 2-(3-aminopropyl)-aminoethyl-phosphorothioate (Amifostin)
- Ethanethiol, 2-[(3-aminopropyl)amino]-, 1-(dihydrogen phosphate)
- Amifostine
- Ethiofos
- Phosphorothioic acid S-(2-((3-aminopropyl)amino)ethyl) ester
- 2-((3-aminopropyl)amino)-ethanethiol,dihydrogenphosphateester
- 2-(3-aminopropylamino)ethylthiophosphate
- acide((amino-3propylamino)-2ethyl)-s-phosphorothioique
- apaetp
- au-95722
- gammaphos
- nsc-296961
- s-(2-(3-aminopropylamino)ethyl)phosphorothioate
- s,2-(3-aminopropylamino)ethyl-phosphorothioicacid
- CS-271
- Amifostine USP/EP/BP
- Amifostine impurity
- AmifostineQ: What is
Amifostine Q: What is the CAS Number of
Amifostine Q: What is the storage condition of
Amifostine Q: What are the applications of
Amifostine
- TIANFUCHEM--20537-88-6--High purity Amifostine factory price
- Ethyol
- Ethyol|||WR2721|||Gammaphos
- 20537-88-6
- C5H15N2O3PS
- Cancer Research
- Antitumor Agents
- BioChemical
- Therapy Adjuncts
- Active Pharmaceutical Ingredients
- Radioprotective Agent
- Intermediates & Fine Chemicals
- Pharmaceuticals
- TIAPRIDAL
- Sulfur & Selenium Compounds
