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ERK Inhibitor

ERK Inhibitor Struktur
1049738-54-6
CAS-Nr.
1049738-54-6
Englisch Name:
ERK Inhibitor
Synonyma:
ERK-IN-4;ERK Inhibitor - CAS 1049738-54-6 - Calbiochem;3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione,monohydrochloride;(5Z)-3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione:hydrochloride
CBNumber:
CB13136749
Summenformel:
C14H17ClN2O3S
Molgewicht:
328.81
MOL-Datei:
1049738-54-6.mol

ERK Inhibitor Eigenschaften

storage temp. 
+2C to +8C
L?slichkeit
DMSO: 2 mg/ml
Aggregatzustand
Light yellow solid
Farbe
Off-white to yellow

Sicherheit

ERK Inhibitor Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 μM). This prevents its interaction with protein substrates without inhibiting catalytic activity. ERK inhibitor blocks ERK-specific phosphorylation of ribosomal S6 kinase-1 and ternary complex factor Elk-1 but does not affect ERK1/2 phosphorylation by MEK1/2. Presumably through its effects on ERK, ERK inhibitor completely prevents proliferation of HeLa cells (IC50 = 15-20 μM), A549 lung carcinoma cells (IC50 = 25 μM), Sum-159 estrogen receptor-negative breast cancer cells and HT1080 fibrosarcoma cells.

Allgemeine Beschreibung

A cell-permeable and reversible thiazolidinedione compound that displays anti-proliferative properties (IC50 ≤ 25 μM in HeLa, A549, and SUM-159 tumor cells). Preferentially binds to ERK2 with a KD of ~5 μM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting little effect on ERK1/2 phosphorylation by MEK1/2.

Biochem/physiol Actions

Primary TargetERK

ERK Inhibitor Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


ERK Inhibitor Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 27)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32118 58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
+8618829768577
gao490372054@gamil.com China 1249 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525
masar@topule.com China 8467 58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
+86-18791163155 +86-13119157289
13119157289@163.com China 2973 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Shanghai Run-Biotech Co., Ltd. 021-57171705 13817537615
sales@run-biotech.com China 2432 58
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51456 80
BOC Sciences 16314854226
info@bocsci.com United States 9923 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
info@efebio.com China 9806 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774
sales@glpbio.cn China 6777 58

1049738-54-6()Verwandte Suche:


  • (5Z)-3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione:hydrochloride
  • ERK Inhibitor - CAS 1049738-54-6 - Calbiochem
  • 3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione,monohydrochloride
  • ERK-IN-4
  • 1049738-54-6
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