(S)-2-AMINO-3-(5-FLUORO-1H-INDOL-3-YL)-PROPIONIC ACID
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- CAS-Nr.
- 16626-02-1
- Englisch Name:
- (S)-2-AMINO-3-(5-FLUORO-1H-INDOL-3-YL)-PROPIONIC ACID
- Synonyma:
- L-Trp(5-F)-OH;H-L-Trp(5-F)-OH*H2O;L-5-FLUOROTRYPTOPHAN;5-FLUORO-L-TRYPTOPHAN;H-5-FLUORO-TRP-OH H2O;Tryptophan Impurity 54;5-fluoro-L-tryptophans;L-Tryptophan, 5-fluoro-;5-Fluoro-tryptophan monohydrate;L-5-fluorotryptophan monohydrate
- CBNumber:
- CB1274150
- Summenformel:
- C11H11FN2O2
- Molgewicht:
- 222.22
- MOL-Datei:
- 16626-02-1.mol
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(S)-2-AMINO-3-(5-FLUORO-1H-INDOL-3-YL)-PROPIONIC ACID Eigenschaften
- Schmelzpunkt:
- 238-239 °C
- Siedepunkt:
- 450.7±45.0 °C(Predicted)
- Dichte
- 1.442±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 2.21±0.10(Predicted)
- BRN
- 5052680
(S)-2-AMINO-3-(5-FLUORO-1H-INDOL-3-YL)-PROPIONIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Verwenden
Exogenous 5-fluoro-Trp is incorporated into proteins in normal protein synthesis. Since
19F is a useful reporter group, this provides a method for studying enzyme mechanisms by NMR.
Biochem/physiol Actions
5-Fluoro-Trp is nonspecifically cytotoxic. It is believed this is due to malfunctioning enzymes that have had replacements of Trp residues by 5-fluoro-Trp. However, at least one case is known where 5-fluoro-Trp substitution leads to significantly greater catalytic activity.
l?uterung methode
Recrystallise it from EtOH, aqueous EtOH or AcOH. Also purify it by passage through a Dowex AG1x2 (acetate form) column and recrystallise the L-enantiomer (from enzymic enrichment) from H2O/EtOH, m 158-163o(dec), [] D -8.3o (c 2.5, N NaOH). [Coy et al. Biochemistry 13 3550 1974, Beilstein 22/14 V 116.]
(S)-2-AMINO-3-(5-FLUORO-1H-INDOL-3-YL)-PROPIONIC ACID Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(S)-2-AMINO-3-(5-FLUORO-1H-INDOL-3-YL)-PROPIONIC ACID Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 82)Lieferanten
16626-02-1()Verwandte Suche:
- 5-FLUORO-L-TRYPTOPHAN
- 5-FLUORO-L-TRYPTOPHAN MONOHYDRATE
- H-5-FLUORO-TRP-OH H2O
- L-5-FLUOROTRYPTOPHAN
- (S)-2-AMINO-3-(5-FLUORO-1H-INDOL-3-YL)-PROPIONIC ACID
- 5-Fluoro-tryptophan monohydrate
- H-L-Trp(5-F)-OH*H2O
- L-5-fluorotryptophan monohydrate
- (S)-5-Fluoro-α-amino-1H-indole-3-propionic acid
- (S)-α-Amino-5-fluoro-1H-indole-3-propionic acid
- (S)-2-AMino-3-(5-fluoro-1H-indol-3-yl)propanoic acid
- L-Tryptophan, 5-fluoro-
- (2S)-2-amino-3-(5-fluoro-1H-indol-3-yl)propanoic acid
- 5-Fluoro-L-tryptophan >=98.0% (HPLC)
- Tryptophan Impurity 54
- 5-fluoro-L-tryptophans
- L-Trp(5-F)-OH
- 16626-02-1
- C11H11FN2O2H2O
- BioChemical
- Biochemicals and Reagents
- Enzyme Inhibitors
- Enzyme Inhibitors by Type
- Enzymes, Inhibitors, and Substrates
- Substrate Analogs
- Unnatural Amino Acid Derivatives
- Tryptophan Derivatives
- F
- Enzyme Inhibitors by Type
- Alphabetic
- Substrate AnalogsPeptide Synthesis
- FA - FLEnzyme Inhibitors
- Indoles and derivatives
