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Primidon

Primidone Struktur
125-33-7
CAS-Nr.
125-33-7
Bezeichnung:
Primidon
Englisch Name:
Primidone
Synonyma:
Cyral;Sertan;roe101;Midone;Roe 101;Mizodin;Mizolin;Mysedon;Misoline;Mizoline
CBNumber:
CB1161900
Summenformel:
C12H14N2O2
Molgewicht:
218.25
MOL-Datei:
125-33-7.mol

Primidon Eigenschaften

Schmelzpunkt:
281-282°C
Siedepunkt:
358.94°C (rough estimate)
Dichte
1.1402 (rough estimate)
Brechungsindex
1.6660 (estimate)
Flammpunkt:
9℃
storage temp. 
Sealed in dry,Room Temperature
L?slichkeit
Very slightly soluble in water, slightly soluble in ethanol (96 per cent). It dissolves in alkaline solutions.
Aggregatzustand
Solid
pka
12.26±0.40(Predicted)
Farbe
White to Off-White
Wasserl?slichkeit
<0.1 g/100 mL at 19 ºC
Merck 
14,7746
BCS Class
2
InChIKey
DQMZLTXERSFNPB-UHFFFAOYSA-N
CAS Datenbank
125-33-7(CAS DataBase Reference)
NIST chemische Informationen
Primidone(125-33-7)
IARC
2B (Vol. 108) 2016
EPA chemische Informationen
Primidone (125-33-7)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn,T,F
R-S?tze: 22-40-39/23/24/25-23/24/25-11
S-S?tze: 22-36-45-36/37-16-7
RIDADR  3249
WGK Germany  3
RTECS-Nr. UV9100000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29335990
Giftige Stoffe Daten 125-33-7(Hazardous Substances Data)
Toxizit?t child,TDLo,oral,625mg/kg (625mg/kg),BEHAVIORAL: SLEEPBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)BEHAVIORAL: GENERAL ANESTHETIC,British Medical Journal. Vol. 1, Pg. 90, 1957.
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H351 Kann vermutlich Krebs verursachen. Karzinogenit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Primidon Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.
R40:Verdacht auf krebserzeugende Wirkung.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Beschreibung

Primidone is chemically and structurally similar to phenobarbital with the exception that the carbonyl group on C2 is replaced by a methylene group. This modification leads to the production of a drug with strong anticonvulsant properties without expressed soporific effects.

Chemische Eigenschaften

Crystalline Solid

Verwenden

Primidone is mainly used for major attacks.

Definition

ChEBI: A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an anticonvulsant for treatment of various types of seizures.

Allgemeine Beschreibung

Odorless white crystalline powder. Slightly bitter taste. No acidic properties.

Air & Water Reaktionen

Insoluble in water.

Reaktivit?t anzeigen

Primidone is an amide. May react with azo and diazo compounds to generate toxic gases. May react with strong reducing agents to form flammable gases. A very weak base. The Combustion generates toxic mixed oxides of nitrogen (NOx).

Brandgefahr

Flash point data for Primidone are not available; however, Primidone is probably combustible.

Biologische Aktivit?t

Anticonvulsant.

Clinical Use

Primidone is the 2-deoxy derivative of phenobarbital and is approved by the U.S. FDA for initial or adjunctive treatment of simple partial, complex partial, and tonic-clonic seizures. It is less effective against these types of seizures than is phenytoin or CBZ, and it shares the antiseizure and sedative actions of phenobarbital. Although not approved for the purpose, it often is used to treat benign familial tremor (essential tremor).

Nebenwirkungen

As with phenobarbital, serious toxicity for primidone is rare, although it may cause disabling sedation, irritability, and decreased mental functioning in a number of persons. Ataxia, dysphoria, idiosyncratic rash, leukopenia, agranulocytosis, lymphadenopathy, hepatitis, and a systemic lupus erythematosus–like syndrome have been reported adverse effects for primidone. Deficiencies of folic acid and of vitamins D and K are possible with long-term therapy of primidone, as is a folateresponsive megaloblastic anemia. Measurement of the complete blood cell count should be performed at 6-month intervals.

Sicherheitsprofil

Poison by ingestion and intraperitoneal routes. Human teratogenic effects include developmental abnormalities of the craniofacial area, skin and skin appendages, and cardlovascular system. Human reproductive effects: effects on newborn, including unusual growth statistics, drug dependence, physical and other neonatal changes. Experimental teratogenic and reproductive effects. Human mutation data reported. An addictive drug. When heated to decomposition it emits toxic fumes of NOx. See also BARBITURATES.

Primidon Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Primidon Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 290)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21638 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 9219 55
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8618959220845
sales@amoychem.com China 6383 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32063 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6312 58
AFINE CHEMICALS LIMITED
+86-0571-85134551
sales@afinechem.com China 15356 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6391 58
Shaanxi Didu New Materials Co. Ltd
+86-89586680 +86-13289823923
1026@dideu.com China 8670 58
LEAP CHEM CO., LTD.
+86-852-30606658
market18@leapchem.com China 24727 58

125-33-7(Primidon)Verwandte Suche:


  • Resimatil
  • Roe 101
  • roe101
  • Sertan
  • 5-ETHYLDIHYDRO-5-PHENYL-4,6(1H,5H)-PYRIMIDINEDIONE
  • 5-phenyl-5-ethyl-hexahydropyrimidine-4,6-dione
  • PRIMIDONE
  • 5-ethyl-5-phenylperhydropyrimidine-4,6-dione
  • PRIMIDONE,USP
  • 4,6-PYRIMIDINEDIONE,5-ETHYLDIHYDRO-5-PHENYL
  • 5-ETHYLDIHYDRO-5-PHENYL-4,6-PYRIMIDINEDIONE
  • 5-Ethyl-5-phenyl-1,3-diazinane-4,6-dione
  • Misoline
  • Mizoline
  • 5-Ethyldiiodro-5-phenyl-4,6(1H,5H)-pyrimidinedione
  • 5-ethyl-5-phenyl-hexahydropyrimidine-4,6-quinone
  • Primidone (200 mg)H0D3991.000mg/mg(dr)
  • PriMidone API
  • 5-Ethyl-5-phenylhexahydropyrimidine-4,6-dione 2-Deoxyphenobarbital
  • PriMidone (Mysoline)
  • 5-ethyl-5-phenyldihydropyriMidine-4,6(1H,5H)-dione
  • Primidone solution
  • 2-deoxyphenobarbital
  • 2-DESOXYPHENOBARBITAL
  • 4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-phenyl-
  • 5-Aethyl-5-phenyl-hexahydropyrimidin-4,6-dion
  • 5-Ethyl-5-phenyldihydro-4,6(1H,5H)-pyrimidinedione
  • 5-Ethyl-5-phenylhexahydropyrimidine-4,6-dione
  • 5-ethylhexahydro-4,6-dioxo-5-phenylphrimidine
  • 5-Ethylhexahydro-4,6-dioxo-5-phenylpyrimidine
  • 5-Ethylhexahydro-5-phenylpyrimidine-4,6-dione
  • 5h)-pyrimidinedione,5-ethyldihydro-5-phenyl-6(1h
  • 5-Phenyl-5-aethylhexahydropyrimidindion-(4,6)
  • Cyral
  • Desoxyphenobarbitone
  • Hexadiona
  • hexamidine(theantispasmodic)
  • Lepimidin
  • Lepsiral
  • Liskantin
  • Majsolin
  • Medi-Pets
  • Midone
  • Milepsin
  • Misodine
  • Misolyne
  • Mizodin
  • Mizolin
  • Mylepsin
  • Mylepsinum
  • Mysedon
  • Mysoline
  • NCI-C56360
  • Neurosyn
  • Prilepsin
  • Primacione
  • Primaclone
  • Primacone
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