Amitriptylin
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- CAS-Nr.
- 50-48-6
- Bezeichnung:
- Amitriptylin
- Englisch Name:
- Amitriptyline
- Synonyma:
- Amitriptylin;amitriptilina;Amitryptiline;Amitryptyline;Elavil;5-(3-dimethylaminopropylidene)-10,11-dihyro-5h-dibenzo(a,d)cycloheptene;5-(3-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptatriene;n750;elani;mk230
- CBNumber:
- CB1159271
- Summenformel:
- C20H23N
- Molgewicht:
- 277.4
- MOL-Datei:
- 50-48-6.mol
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Amitriptylin Eigenschaften
- Schmelzpunkt:
- 196-197°C
- Siedepunkt:
- 410.26°C (rough estimate)
- Dichte
- 0.9415 (rough estimate)
- Brechungsindex
- 1.7500 (estimate)
- storage temp.
- Store at -20°C
- Aggregatzustand
- Liquid
- pka
- 9.4(at 25℃)
- Farbe
- Colorless to light yellow
- Wasserl?slichkeit
- 9.7 mg/mL
- Stabilit?t:
- Light Sensitive
- CAS Datenbank
- 50-48-6(CAS DataBase Reference)
- NIST chemische Informationen
- Amitriptyline(50-48-6)
- EPA chemische Informationen
- Amitriptyline (50-48-6)
Amitriptylin Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Amitriptyline is used for anxious-depressive conditions. It is easier to tolerate than
imipramine.
Definition
ChEBI: An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Weltgesundheitsorganisation (WHO)
Amitriptyline, a tricyclic antidepressant was introduced in 1961
for the management of endogenous depression and is listed in the 8th WHO Model
List of Essential Drugs. Much of the adverse effects are caused by its
antimuscarinic actions. These include dry mouth, cardiac arrhythmias, central
nervous system disturbances, blood disorders and risk of suicide. The risk of
suicide and dangers related to overdosage led the Norwegian Medicines Control
Authority to put the higher strength formulation under prescribing restriction in
1992. The risk of death following overdosage is apparently higher for products
containing tricyclic compounds as compared with nontricyclic products.
Biologische Funktion
Amitriptyline is a tertiary amine dibenzocycloheptadiene TCA with a propylidene side chain extending from the central carbocyclic ring. The diarylpropylideneamine moiety for amitriptyline makes it sensitive to
photo-oxidation; therefore, its hydrochloride solutions should be protected from light to avoid ketone
formation and precipitation.
Pharmakokinetik
Amitriptyline is rapidly absorbed from the GI tract and from parenteral sites.Amitriptyline and its active metabolite, nortriptyline, are distributed into breast milk.
Amitriptyline is primarily (65%) metabolized by N-demethylation by CYP2D6 to nortriptyline and hydroxylation
to its E-10-hydroxy metabolite. Nortriptyline is pharmacologically active as a secondary amine TCA.
Amitriptyline shows approximately equal affinity for 5-HT and NE transporters.
Amitriptylin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Amitriptylin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 100)Lieferanten
50-48-6(Amitriptylin)Verwandte Suche:
Dimethylphthalat
Ethan
Dimethyl ether
Dimethylfumarat
N,N-Dimethylformamid
Propan
Dimethylcarbonat
Dimethylsulfat
Dimethylsulfoxid
Chlorthal-dimethyl
(-)-Methyl(α-methylphenethyl)amin
Amphetamin
3-(10,11-Dihydro-5H-dibenzo(a,d)-cyclohepten-5-yliden)-N,N-dime-thyl-1-propanamin-hydrochlorid
3-(10,11-Dihydro-5H-dibenzo(a,d)-cyclohepten-5-yliden)-N-methyl-1-propanamin-hydrochlorid
Cyclohepten
1,3,5-Cycloheptatrien
10,11-Dihydro-5H-dibenzo[a,d]cyclohepten
Dibenzo[b,f]cycloheptan-1-on
- 5-(3-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene
- 5-(3'-Dimethylaminopropylidene)-dibenzo-(a,d)(1,4)-cycloheptadiene
- 5-(3-Dimethylpropylidene)dibenzo(a,d)(1,4)cycloheptadiene
- 5-(gamma-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene
- 5-(gamma-Dimethylaminopropylidene)-5H-dibenzo(a,d)-10,11-dihydrocycloheptene
- 5-(gamma-Dimethylaminopropylidene)-5H-Dibenzo[a,d][1,4]cycloheptadiene
- 5-(gamma-Dimethylaminopropylidine)-5H-dibenzo(a,d)(1,4)cycloheptadiene
- 3-(10,11-dihydro-5h-dibenzo(a,d)cyclohepten-5-ylidene)-n,n-dimethyl-1-propan
- 5-(3’-dimethylaminopropylidene)-dibenzo-(a,d)(1,4)-cycloheptadiene
- Damitriptyline
- elani
- Elanil
- Flavyl
- Lantron
- Laroxil
- Laroxyl
- Lentizol
- mk230
- MK-230
- N 750
- n750
- Proheptadiene
- 5h-dibenzo(a,d)cycloheptene-delta(5,gamma)-propylamine,10,11-dihydro-n,n-dimet
- 5H-Dibenzo[a,d]cycloheptene-delta5,gamma-propylamine, 10,11-dihydro-N,N-dimethyl-
- Adepress
- Adepril
- Amytriptiline
- d)cyclopheptene-delta(sup5),gamma-propylamine,10,11-dihydro-n,n-5h-dibenzo(
- Damilan
- Damilen
- AMITRIPTYLINE
- AMITRYPTYLLINE NA
- 10,11-Dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo(a,d)cycloheptene
- 10,11-dihydro-n,n-dimethyl-5h-dibenzo(a,d)heptalene-delta(sup5),gamma-propyl
- 10,11-Dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-delta5,gamma-propylamine
- 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-
- redomex
- Ro 4-1575
- ro4-1575
- sarotex
- Seroten
- Triptanol
- Triptisol
- Tryptanol
- Tryptizol
- Larxyl
- 3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethyl-1-propanamine
- 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-diMethylpropan-1-aMine
- 3-(10,11-dihydro-5h-dibenzo[a,d]cyclohepten-5-ylidene)-n,n-dimethyl-1-propanamine
- [3-(10,11-DIHYDRO-DIBENZO[A,D]CYCLOHEPTEN-5-YLIDENE)-PROPYL]-DIMETHYL-AMINE
- AMITRIPTHYLINE
- DIBENZOSUBERONE /AMITRIPTYLINE
- Amitriptyline (base and/or unspecified salts)
- MK-230, N-750, Ro41575
- 3-(5,6-DIHYDRODIBENZO[2,1-B:2',1'-F][7]ANNULEN-11-YLIDENE)-N,N-DIMETHYLPROPAN-1-AMINE
- Amitriptyline USP/EP/BP
- 1-Methyl-6-oxo-1
- 6-dihydropyridine-3-carboxylic acid
