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2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E

2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E Struktur
141286-78-4
CAS-Nr.
141286-78-4
Englisch Name:
2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E
Synonyma:
PEPA,inhibit,Inhibitor,iGluR,Ionotropic glutamate receptors;2-[2,6-Difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]acetamide;Acetamide, 2-[2,6-difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]-;2,6-Difluoro-4-[2-(phenylsul-fonyl-amino)-ethyl-thio]-phenoxy-acet-amide (PEPA)
CBNumber:
CB0972925
Summenformel:
C16H16F2N2O4S2
Molgewicht:
402.44
MOL-Datei:
141286-78-4.mol

2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E Eigenschaften

Siedepunkt:
617.6±65.0 °C(Predicted)
Dichte
1.47±0.1 g/cm3(Predicted)
storage temp. 
protect from light
L?slichkeit
DMSO: >20mg/mL
Aggregatzustand
solid
pka
10.44±0.40(Predicted)
Farbe
white
InChIKey
GTACSIONMHMRPD-UHFFFAOYSA-N

Sicherheit

WGK Germany  3

2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

PEPA is an allosteric potentiator of AMPA desensitization.

Biologische Aktivit?t

Novel allosteric potentiator of AMPA receptor desensitization. Slows the rate of onset of desensitization and potentiates steady-state equilibrium currents induced by glutamate with subunit (GluR3/4 > GluR1) and splice variant (flop > flip) selectivity. Ameliorates post-ischemic memory impairment in rats following i.v. administration.

Biochem/physiol Actions

2,6-Difluoro-4-[2-(phenylsul-fonyl-amino)-ethyl-thio]-phenoxy-acet-amide is a structurally novel, selective, high affinity AMPA ionotropic glutamate receptor agonist that reduces ischemia-induced performance deficits in rats.

2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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141286-78-4()Verwandte Suche:

  • 2-[2,6-Difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]acetamide
  • 2,6-Difluoro-4-[2-(phenylsul-fonyl-amino)-ethyl-thio]-phenoxy-acet-amide (PEPA)
  • PEPA,inhibit,Inhibitor,iGluR,Ionotropic glutamate receptors
  • Acetamide, 2-[2,6-difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]-
  • 141286-78-4
  • C16H16N2O4S2F2
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