N-ACETYL-4-BENZOQUINONE IMINE
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- CAS-Nr.
- 50700-49-7
- Englisch Name:
- N-ACETYL-4-BENZOQUINONE IMINE
- Synonyma:
- napqi;N-Acetylimidoquinone;N-ACETYL-P-BENZOQUINONE IMINE;N-Acetyl-p-benzoquinonimine;Chebi:29132;acetimidoquinone;n-acetyl-p-quinonimine;N-ACETYLBENZOQUINONE-IMINE;N-ACETYL-PARA-QUINONEIMINE;N-acrtyl Benzoquinoneimine
- CBNumber:
- CB0696629
- Summenformel:
- C8H7NO2
- Molgewicht:
- 149.15
- MOL-Datei:
- 50700-49-7.mol
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N-ACETYL-4-BENZOQUINONE IMINE Eigenschaften
- Schmelzpunkt:
- 74-75
- Siedepunkt:
- 255.6±43.0 °C(Predicted)
- Dichte
- 1.13±0.1 g/cm3(Predicted)
- storage temp.
- -70°C
- L?slichkeit
- Chloroform (Slightly, Sonicated), DMSO (Slightly)
- Aggregatzustand
- Solid
- pka
- -3.37±0.20(Predicted)
- Farbe
- Pale Yellow to Very Dark Red
- Stabilit?t:
- Temperature, Moisture, Light, and Oxygen Sensitive
- CAS Datenbank
- 50700-49-7
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| RTECS-Nr. |
AC6960000 |
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| HS Code |
2902110000 |
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| Toxizit?t |
LD50 i.p. in male BALB/c mice: 20 mg/kg (Dahlin, Nelson) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P332+P313 |
Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P337+P313 |
Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P362 |
Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen. |
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N-ACETYL-4-BENZOQUINONE IMINE Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
N-
Acetyl-
4-
benzoquinone imine (NAPQI) is a cytochrome P450 3A4 and 2E1 metabolite of acetaminophen that can be toxic to the liver when acetaminophen is consumed in large doses. At therapeutic doses of acetaminophen, NAPQI is inactivated by conjugation with glutathione. However, following toxic doses of acetaminophen, available liver reserves of glutathione are quickly depleted due to clearance of excess NAPQI, which enables hepatic proteins to become covalently modified by reactive metabolites and eventually results in hepatocyte necrosis.
Chemische Eigenschaften
Yellow Crystalline Solid
Verwenden
N-Acetyl-4-benzoquinone imine (NAPQI) is a cytochrome P450 3A4 and 2E1 metabolite of acetaminophen that can be toxic to the liver when acetaminophen is consumed in large doses. At therapeutic doses of acetaminophen, NAPQI is inactivated by conjugation with glutathione. However, following toxic doses of acetaminophen, available liver reserves of glutathione are quickly depleted due to clearance of excess NAPQI, which enables hepatic proteins to become covalently modified by reactive metabolites and eventually results in hepatocyte necrosis.
N-ACETYL-4-BENZOQUINONE IMINE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
N-ACETYL-4-BENZOQUINONE IMINE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 89)Lieferanten
50700-49-7()Verwandte Suche:
- N-ACETYLBENZOQUINONE-IMINE
- N-N-Acetyl-4-benzoquinone Imine
- N-ACETYL-PARA-QUINONEIMINE
- N-Acetyl-p-benzoquinone imine (NAPQI), 98%
- 4-(Acetylimino)-2,5-cyclohexadien-1-one
- N-(4-Oxo-1-cyclohexa-2,5-dienylidene)acetamide, N-Acetyl-p-benzo-quinone imine, NAPQI
- N-Acetyl-1,4-benzoquinone imine
- Chebi:29132
- N-(4-Oxocyclohexa-2,5-dien-1-ylidene)acetamide
- N-(4-Oxo-1-cyclohexa-2,5-dienylidene)acetamide
- 4-acetylimino-5-cyclohexadien-1-one
- acetimidoquinone
- n-(4-oxo-2,5-cyclohexadien-1-ylidene)-acetamid
- n-(4-oxo-2,5-cyclohexadien-1-ylidene)acetamide
- n-(4-oxo-2,5-cyclohexadienylidene)acetamide
- n-acetyl-p-quinonimine
- N-ACETYL-4-BENZOQUINONE IMINE
- Phenylephrine Impurity 23(N-Acetyl-4-Benzoquinone Imine)
- N-acrtyl Benzoquinoneimine
- Acetamide, N-(4-oxo-2,5-cyclohexadien-1-ylidene)-
- Phenylephrine Impurity 7 (N-Acetyl-4-Benzoquinone Imine)
- N-ACETYL-P-BENZOQUINONE IMINE
- napqi
- N-Acetyl-p-benzoquinonimine
- N-Acetylimidoquinone
- 50700-49-7
- 50600-49-7
- Organic Building Blocks
- Nitrogen Compounds
- Imines/Amidines
- Building Blocks
- Chemical Synthesis
- Imines/Amidines
- Nitrogen Compounds
- Organic Building Blocks
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- Metabolites & Impurities
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