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Heparin sodium

Heparin sodium Struktur
9041-08-1
CAS-Nr.
9041-08-1
Englisch Name:
Heparin sodium
Synonyma:
SODIUM HEPARIN;HEPARIN SODIUM SALT;PORCINE HEPARIN SODIUM;HEPARIN SODIUM INJECTION;Heparin sodium salt (MW 15kDa);LOW MOLECULAR WEIGHT HEPARIN SODIUM;Heparin for physico-chemical analysis CRS;Fragmin;normiflo;Panheprin
CBNumber:
CB0439583
Summenformel:
(C12H16NS2Na3)20
Molgewicht:
0
MOL-Datei:
Mol file

Heparin sodium Eigenschaften

Schmelzpunkt:
>181°C (dec.)
alpha 
D25 +47° (c = 1.5 in water)
storage temp. 
2-8°C
L?slichkeit
H2O: 50 mg/mL, clear, faintly yellow
Aggregatzustand
crystalline (fine)
Farbe
white
PH
pH (10g/l, 25℃) : 6.0~8.0
Wasserl?slichkeit
Soluble in water, dimethyl sulfoxide and ethanol.
Merck 
14,4653
Stabilit?t:
Stable. Incompatible with strong oxidizing agents, strong bases.
CAS Datenbank
9041-08-1
EPA chemische Informationen
Heparin, sodium salt (9041-08-1)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
R-S?tze: 36/37/38-42/43
S-S?tze: 22-24-26-36/37
WGK Germany  2
RTECS-Nr. MI0850000
3-10
TSCA  Yes
HS Code  30019010
Toxizit?t LD50 oral in rat: > 779000iu/kg
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P271 Nur im Freien oder in gut belüfteten R?umen verwenden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

Heparin sodium Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt m?glich.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24:Berührung mit der Haut vermeiden.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.

Beschreibung

Reviparin sodium, a second-generation low molecular weight heparin produced from porcine mucosal heparin, has been introduced for the prevention of deep vein thrombosis and pulmonary embolism following surgery. It has sustained activity and increased bioavailability over unfractioned heparin. More noticeably, reviparin shows a pronounced inhibitory effect, both in vitro and in vivo , on smooth muscle cell proliferation which plays a predominant role in restenosis following angioplasty. Indeed, a lower incidence of restenosis without major bleeding complications has been reported for reviparin treated patients who successfully underwent percutaneous transluminal coronary angioplasty.

Chemische Eigenschaften

off-white powder

Verwenden

Heparin sodium salt is used as a blood anti-coagulant. It is also used as an effective inhibitor of mesenchymal cell proliferation. Further, it binds to antithrombin III, which inhibits coagulation proteases. It is used as a major component of serum free media for preventing cell aggregation. It is also used as an anti-cancer agent in in vitro cancer research.

Allgemeine Beschreibung

Heparin is mainly responsible for the delay in the coagulation of blood. It enhances the antithrombin-mediated inactivation of proteases in the coagulation pathway.

l?uterung methode

Dissolve the salt in 0.1M NaCl (1g/100mL) and precipitate it by additing EtOH (150mL). [Wolfrom et al. J Org Chem 29 540 1946, Huggard Adv Carbohydr Chem 10 336-368 1955.]

Heparin sodium Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Heparin sodium Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 573)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hubei Xindesheng Material Technology Co., Ltd.
+8618971041571
vickyzhao@whdschem.com China 174 58
Guangzhou TongYi biochemistry technology Co.,LTD
+8613073028829
mack@tongyon.com China 2994 58
Wuhan Fortuna Chemical Co.,Ltd
+8618007136271
hk@fortunachem.com China 5998 58
HUARONG(GUANGDONG) PHARMACEUTICAL CO.,LTD
+86-19925801629 +86-19925801629
eric@huarongpharma.com China 171 58
Guangzhou Tosun Pharmaceutical Ltd
+86-020-61855200-902 +8618124244216
info@upharm.cn China 831 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
Hebei Weibang Biotechnology Co., Ltd
+8617732866630
bess@weibangbio.com China 18151 58
Guangzhou Tengyue Chemical Co., Ltd.
+86-86-18148706580 +8618826483838
evan@tyvovo.com China 148 58
Hebei Jingbo New Material Technology Co., Ltd
+8619931165850
hbjbtech@163.com China 1000 58
Hebei Saisier Technology Co., LTD
+86-18400010335 +86-18034520335
admin@hbsaisier.cn China 1015 58

9041-08-1()Verwandte Suche:


  • HEPARINSODIUM(FDA)
  • HEPARIN SODIUM SALT, FROM PORCINE MUCOSA
  • HEPARINNA OR CA SALT (CRUDE: 100 USP U/MG): PORCINE INTESTINAL MUCOSA
  • Hoechst ,Na
  • Heparin sodium salt from bovine lung
  • Nadroparine sodium
  • Heparin Sodium Identification (50 mg) (COLD SHIPMENT REQUIRED)
  • Heparin sodiuM salt ,0% [>170 units/Mg]
  • Dalteparin sodiuM(Parnaparin SodiuM)
  • Heparin sodium salt from swine mucosa
  • Heparin SodiuM, injectable grade
  • Nadroparin CalciuM EP
  • Heparin SodiuM Identification
  • Heparin sodium 180 U/mg
  • Heparin sodium for assays
  • Heparin for physico-chemical analysis
  • Heparin sodium for NMR identification
  • Heparin sodium porcine mucosa
  • Enoxaparin Sodium (300 mg)
  • Enoxaparin Sodium Molecular Weight Calibrant A (8.0 mg)
  • Enoxaparin Sodium Molecular Weight Calibrant B (6.0 mg)
  • Low Molecular Weight Heparin for Bioassays
  • Low Molecular Weight Heparin Molecular Weight Calibrant (10.6 mg)
  • Heparin sodium salt, derived from porcine intestinal mucosa
  • Heparin sodium saltfrom porcine intestinal mucosa≥ 180?USP units/mg
  • SODIUM HEPARINATE
  • BOVINE HEPARIN SODIUM
  • HEP, NA, BOVINE
  • HEP, NA, PORCINE
  • HEPARIN PORCINE SODIUM SALT
  • HEPARIN SODIUM
  • HEPARIN SODIUM (BOVINE)
  • HEPARIN SODIUM LMW
  • HEPARIN SODIUM, PORCINE
  • HEPARIN, SODIUM SALT, BOVINE
  • HEPARIN, SODIUM SALT, PORCINE
  • HEPARIN, SODIUM SALT, PORCINE INTESTINAL MUCOSA
  • HEPARIN, SODIUM SALT, PORCINE INTESTINAL MUCOSA, LOW MOLECULAR WEIGHT
  • alfa87-120
  • alfa87-163
  • alfa87-198
  • alfa87-247
  • alfa87-81
  • dalteparinsodium
  • inno-hep
  • ro11
  • rp54563
  • sodiumacidheparin
  • HEPARIN SODIUM SALT FROM BOVINE LUNG, ~140 U/MG*
  • HEPARIN SODIUM FROM PORCINE*INTESTINAL M UCOSA
  • HEPARIN SODIUM FROM OVINE INTESTINAL*MUC OSA
  • HEPARIN SODIUMSALT F. PORCINE INTEST. MUCOSA, ~140 U/MG*
  • HEPARIN LOW MOLECULAR WEIGHT SODIUM*FROM PORCINE
  • HEPARIN SODIUM CRUDE UNBLEACHED FROM*POR CINE INTEST
  • HEPARIN LOW MOLECULAR WEIGHT SODIUM AV. MOL. WT. AP
  • HEPARIN SODIUM SALT F. PORCINE INTEST. MUCOSA, PH EUR
  • HEPARIN SODIUM GRADE I-A FROM PORCINE*IN TESTINAL MU
  • HEPARIN SODIUM SALT FROM PORCINE INTEST. MUCOSA, ~170 U/MG
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