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Acetazolamid

Acetazolamide Struktur
59-66-5
CAS-Nr.
59-66-5
Bezeichnung:
Acetazolamid
Englisch Name:
Acetazolamide
Synonyma:
6063;Diamox;Acetazolamid;Acetazolamide for system suitability CRS;N-(5-SULFAMOYL-1,3,4-THIADIAZOL-2-YL)ACETAMIDE;N-(5-[AMINOSULFONYL]-1,3,4-THIADIAZOL-2-YL)ACETAMIDE;Didoc;Donmox;Edemox;Glupax
CBNumber:
CB0430959
Summenformel:
C4H6N4O3S2
Molgewicht:
222.25
MOL-Datei:
59-66-5.mol

Acetazolamid Eigenschaften

Schmelzpunkt:
258-259 °C
Dichte
1.610 (estimate)
Brechungsindex
1.6270 (estimate)
storage temp. 
2-8°C
L?slichkeit
Soluble in NH4OH (50 mg/mL), DMSO, Methanol and slightly soluble in Ethanol.
pka
7.2(at 25℃)
Aggregatzustand
solid
Farbe
White to Off-White
Wasserl?slichkeit
<0.1 g/100 mL at 22 ºC
maximale Wellenl?nge (λmax)
265nm(H2O)(lit.)
Merck 
14,53
BRN 
212994
BCS Class
4
Stabilit?t:
Hygroscopic
InChIKey
BZKPWHYZMXOIDC-UHFFFAOYSA-N
CAS Datenbank
59-66-5(CAS DataBase Reference)
NIST chemische Informationen
2-Acetylamino-1,3,4-thiadiazole-5-sulfonamide(59-66-5)
EPA chemische Informationen
Acetazolamide (59-66-5)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/38-36/37/38
S-S?tze: 26-36
RIDADR  2811
WGK Germany  2
RTECS-Nr. AC8225000
TSCA  Yes
HazardClass  6.1
PackingGroup  III
HS Code  29350090
Giftige Stoffe Daten 59-66-5(Hazardous Substances Data)
Toxizit?t LD50 oral in mouse: 4300mg/kg
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P332+P313 Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P337+P313 Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Acetazolamid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/38:Reizt die Augen und die Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Acetazolamide is a weak diuretic with limited use in edema associated with cardiac insufficiency, glaucoma, minor epileptic attacks, and altitude sickness.

Chemische Eigenschaften

White Solid

Verwenden

Acetazolamide is used for epilepsy in the absence of attacks and also in conjunction with other antiepileptic drugs.

Allgemeine Beschreibung

White to yellowish-white fine crystalline powder. No odor or taste.

Air & Water Reaktionen

Insoluble in water.

Reaktivit?t anzeigen

A weak acid and a diazo derivative. Azo, diazo, azido compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids. Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides.

Brandgefahr

Flash point data for Acetazolamide are not available; however, Acetazolamide is probably combustible.

Mechanism of action

Acetazolamide is an aromatic sulfonamide used as a carbonic anhydrase inhibitor. It facilitates production of alkaline urine with an elevated biocarbonate, sodium, and potassium ion concentrations. By inhibiting carbonic anhydrase, the drug suppresses reabsorption of sodium ions in exchange for hydrogen ions, increases reflux of bicarbonate and sodium ions and reduces reflux of chloride ions. During this process, chloride ions are kept in the kidneys to cover of insufficiency of bicarbonate ions, and for keeping an ion balance. Electrolytic contents of fluid secreted by the kidneys in patients taking carbonic anhydrase inhibitors are characterized by elevated levels of sodium, potassium, and bicarbonate ions and a moderate increase in water level. Urine becomes basic, and the concentration of bicarbonate in the plasma is reduced.

Clinical Use

Acetazolamide was the first of the carbonic anhydrase inhibitors to be introduced as an orally effective diuretic, with a diuretic effect that lasts approximately 8 to 12 hours. As mentioned earlier, its diuretic action is limited because of the systemic acidosis it produces. Acetazolamide reduces the rate of aqueous humor formation and is used primarily for reducing intraocular pressure in the treatment of glaucoma. The dose is 250 mg to 1 g per day.

Sicherheitsprofil

Poison by subcutaneous and intravenous routes. Moderately toxic by intraperitoneal route. Human systemic effects by ingestion: dyspnea. An experimental teratogen by many routes. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx, and SOx,. A carbonic anhydrase inhibitor and dmretic used to treat glaucoma.

l?uterung methode

It is recrystallised from water. [Roblin & Clapp J Am Chem Soc 72 4890 1950, Beilstein 27 III/IV 8219.]

Acetazolamid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Acetazolamid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 409)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8810 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12835 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5857 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Nanjing Gold Pharmaceutical Technology Co. Ltd.
025-84209270 15906146951
CHINA 115 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555 +8617317452075
jack.li@time-chemicals.com China 1803 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 9087 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
sales@fine-chemtech.com CHINA 885 55
Shanxi Naipu Import and Export Co.,Ltd
+86-13734021967 +8613734021967
kaia@neputrading.com China 1001 58

59-66-5(Acetazolamid)Verwandte Suche:


  • N-[5-(AMINOSULFONYL)-1,3,4-THIADIOZOL-2-YL]-ACETAMIDE
  • N-(5-SULFAMOYL-1,3,4-THIADIAZOL-2-YL)ETHANAMIDE
  • DIACARB
  • LABOTEST-BB LT00012571
  • 2-ACETAMINO-1,3,4-THIADIAZOLE-5-SULFONAMIDE
  • 2-acetamido-5-sulfamoyl-1,3,4-thiadiazole
  • 2-ACETYLAMINO-1,3,4-THIADIAZOLE-5-SULFONAMIDE
  • 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE
  • ACETAZOLAMIDE
  • ACETAMIDE N-(5-(AMINO SULPHONYL)-1,3,4 THIADIAZOL-2-YL)
  • 1,3,4-Thiadiazole-2-sulfonamide, 5-acetamido-
  • 2-Acetamido-5-sulfonamido-1,3,4-thiadiazole
  • 4-Diamox
  • 4-thiadiazole-2-sulfonamide,5-acetamido-3
  • 5-Acetamide-1,3,4-thiadiazole-2-sulfonamide
  • 5-Acetamido-1,3,4-thiadiazol-2-sulfonamide
  • Acetamide, N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-
  • Acetamide, N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]-
  • Acetamidothiadiazolesulfonamide
  • Acetamox
  • Acetazoleamide
  • Acetozalamide
  • Atenezol
  • Carbonic anhydrase inhibitor
  • Carbonic anhydrase inhibitor 6063
  • Carbonic anhydrase inhibitor no. 6063
  • carbonicanhydraseinhibitorno.6063
  • carbonicanhydraseinhibitorno6063
  • Cidamex
  • Defiltran
  • Dehydratin
  • Diakarb
  • Didoc
  • Diluran
  • Diuramid
  • Diureticum-holzinger
  • Diuriwas
  • Diutazol
  • Donmox
  • Duiramid
  • Edemox
  • Eumicton
  • Fonurit
  • Glaupax
  • Glupax
  • n-(5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl)-acetamid
  • n-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-acetamid
  • n-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]-acetamid
  • Natrionex
  • Nephramid
  • Nephramide
  • Phonurit
  • SK-acetazolamide
  • Acetamidothiadiazolesu
  • Acetazolamide IMP
  • WLN: T5NN DSJ CSZW EMV1
  • Acetazolamine
  • Vetamox
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