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Tauroursodeoxycholic acid

Tauroursodeoxycholic acid Struktur
14605-22-2
CAS-Nr.
14605-22-2
Englisch Name:
Tauroursodeoxycholic acid
Synonyma:
TUDCA;Taurolite;ursodeoxycholyltaurine;Tauroursodeoxycholic acid-D4;TUDCA Tauroursodeoxycholic Acid;tauroursodeoxycholic acid sodium;Tauroursodeoxycholic Acid (TUDCA);Tauroursodeoxycholic Acid-[d4] Sodium Salt;3a,7b-Dihydroxy-5b-cholan-24-oic Acid N-(2-Sulfoethyl)amide;ur906
CBNumber:
CB0404332
Summenformel:
C26H45NO6S
Molgewicht:
499.7
MOL-Datei:
14605-22-2.mol

Tauroursodeoxycholic acid Eigenschaften

Schmelzpunkt:
173-175°C
Dichte
1.216±0.06 g/cm3(Predicted)
Brechungsindex
46 ° (C=1, EtOH)
storage temp. 
15-25℃
L?slichkeit
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 20 mg/ml with warming)
Aggregatzustand
solid
pka
1.42±0.50(Predicted)
Farbe
White
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey
BHTRKEVKTKCXOH-LBSADWJPSA-N
SMILES
[C@@]12([H])CC[C@H]([C@H](C)CCC(=O)NCCS(=O)(=O)O)[C@@]1(C)CC[C@]1([H])[C@@]3(C)CC[C@@H](O)C[C@@]3([H])C[C@H](O)[C@@]21[H] |&1:0,4,5,18,22,24,28,31,34,36,r|
CAS Datenbank
14605-22-2(CAS DataBase Reference)

Sicherheit

S-S?tze: 22-24/25
WGK Germany  2
RTECS-Nr. KI7372500
HS Code  29242990
Toxizit?t mouse,LD50,intravenous,350mg/kg (350mg/kg),Japanese Kokai Tokyo Koho Patents. Vol. #92-235918,

Tauroursodeoxycholic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid synthesized in hepatocytes by the conjugation of ursodeoxycholic acid (UDCA) with the amino acid taurine. UDCA, which is made by gut bacteria, is FDAapproved in the United States for the treatment of certain cholestatic liver diseases. Humans make TUDCA to some extent, but it is found in copious amounts in the bile of bears. TUDCA is a classic inhibitor of endoplasmic reticulum (ER) stress. Reduces ER stress and adipose tissue inflammation in a mouse model of high fat diet-induced obesity. Blocks ER stress-induced NLRP3 inflammasome activation and hepatocyte death. Attenuates amyloid precursor protein processing and amyloid-β deposition in APP/PS1 mouse model.

Chemische Eigenschaften

Tauroursodeoxycholic acid is an off-White Solid. It is an ambiphilic bile acid. It is mainly found in black bear bile, which is the signature active ingredient in bear bile. It has antispasmodic, anticonvulsant, anti-inflammatory and gallstone dissolving effects.

Verwenden

Tauroursodeoxycholic acid (TUDCA) is a water-soluble bile salt naturally occurring in the body. When bile salts reach the intestines, they can be metabolized by bacteria into ursodeoxycholic acid (UDCA). TUDCA is formed when taurine binds to UDCA. TUDCA is used to treat cholestasis, a condition in which bile fails to flow from the liver to the duodenum. TUDCA, UDCA, and other soluble bile salts can counteract the toxicity of regular bile acids when the latter are backed up in the liver. TUDCA is also used to treat cholesterol gallstones, dissolving them to a size in which they may be passed.

Definition

ChEBI: Tauroursodeoxycholic acid is a bile acid taurine conjugate derived from ursoodeoxycholic acid. It has a role as a human metabolite, an anti-inflammatory agent, a neuroprotective agent, an apoptosis inhibitor, a cardioprotective agent and a bone density conservation agent. It derives from an ursodeoxycholic acid. It is a conjugate acid of a tauroursodeoxycholate.

Nebenwirkungen

TUDCA is safe and well-tolerated in patients with liver transplants, liver cirrhosis, and other diseases, but no clinical data exist for treatments longer than 1 year.
There were no significant differences in adverse events between those receiving standard immunosuppressants versus those receiving bile acids in addition. Other trials in liver cirrhosis (up to 6 months) and ALS (1 year) have also reported that TUDCA is well-tolerated with diarrhea being the only side effect (Elia et al., 2016; Ma et al., 2016; Pan et al., 2013; Crosignani et al., 1996).
Tauroursodeoxycholic-Acid-Cognitive-Vitality-For-Researchers

Mode of action

Tauroursodeoxycholic acid is a bile acid taurine conjugate derived from ursodeoxycholic acid. Bile acid is made by the liver and stored in the gallbladder and helps with digestion. It has a role as a human metabolite, an anti-inflammatory agent, a neuroprotective agent, an apoptosis inhibitor, a cardioprotective agent and a bone density conservation agent. TUDCA is found in small quantities in human bile but at a higher concentration in the bile of black bears, which is the signature active ingredient in bear bile. It demonstrates anti-apoptotic activity in rodent models of tauopathy, Huntington's disease, ischemic brain injury, and retinal disorders.

Tauroursodeoxycholic acid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Tauroursodeoxycholic acid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 551)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
SICHUAN XIELI PHARMACEUTICAL CO.,LTD.
+86-028-60118998 +8615830127659
sales7@xielipharm.com China 31 58
Shandong Natural Micron Pharm Tech Co.,LTD
+86-18653895227
info@nmpharmtech.com China 94 58
Wuhan senwayer century chemical Co.,Ltd
+undefined-27-86652399 +undefined13627115097
market02@senwayer.com China 902 58
Firsky International Trade (Wuhan) Co., Ltd
+8615387054039
admin@firsky-cn.com China 427 58
Shaanxi Xianhe Biotech Co., Ltd
+8617709210191
Jerry@xhobio.com China 484 58
HUBEI VITORCOME PHARMACEUTICAL CO.,LTD
+8615629646827
hgsk@saikangpharm.com China 8 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8816 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5858 58
Shanghai UCHEM Inc.
+862156762820 +86-13564624040
sales@myuchem.com China 7388 58
Wuhan Fortuna Chemical Co., Ltd
+86-027-59207850
info@fortunachem.com China 5986 58

14605-22-2()Verwandte Suche:


  • yl)amino)-
  • Ursodeoxycholyltaurin
  • 3α,7β-dihydroxy-5β-cholan-24-oic acid n-(2-sulfoethyl)amide
  • TUDCA Soduim Salt
  • TAUROURSODEOXYCHOLIC ACID DIHYDRATE: 90%
  • 2-[[(3a,5,7)-3,7-Dihydroxy-24-oxocholan-24-yl]amino]ethanesulfonic Acid Sodium Salt
  • 3a,7-Dihydroxy-5-cholan-24-oic Acid N-(2-Sulfoethyl)amide
  • Tauroursodeoxycholic acid sodium salt, 3α,7β-Dihydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide
  • 2-[(3α,7β-Dihydroxy-24-oxo-5β-cholan-24-yl)amino]ethanesulfonic acid
  • 2-[[(3α,5β,7β)-3,7-Dihydroxy-24-oxocholan-24-yl]amino]ethanesulfonic acid
  • N-(2-Sulfoethyl)-3α,7β-dihydroxy-5β-cholan-24-amide
  • 3ALPHA,7BETA-DIHYDROXY-5BETA-CHOLAN-24-OIC ACID N-(2-SULFOETHYL)AMIDE
  • TAUROURSODEOXYCHOLIC ACID
  • TAUROURSODESOXYCHOLIC ACID
  • 2-(((3-alpha,5-beta,7-beta)-3,7-dihydroxy-24-oxocholan-24-ethanesulfonicaci
  • 2-(((3-alpha,5-beta,7-beta)-3,7-dihydroxy-24-oxocholan-24-yl)amino)ethanesul
  • fonicacid
  • n-(3-alpha,7-beta-dihydroxy-5-beta-cholan-24-oyl)-taurin
  • ur906
  • 2-(((3-alpha,5-beta,7-beta)-3,7-Dihydroxy-24-oxocholan-24-yl)amino)ethanesulfonic acid
  • Ethanesulfonic acid, 2-(((3-alpha,5-beta,7-beta)-3,7-dihydroxy-24-oxocholan-24-yl)amino)-
  • Taurine, N-(3-alpha,7-beta-dihydroxy-5-beta-cholan-24-oyl)-, (8ci)
  • Tauroursodeoxycholic acid (6ci,7ci)
  • TUDCA (tauroursodexycholic acid)
  • Sodium tauroursodeoxycholate,3α,7β-Dihydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide, Tauroursodeoxycholic acid sodium salt
  • Tauroursedeoxycholic acid
  • tauroursodeoxycholate SodiuM (tauroursodeoxycholic acid) (TUDCA)
  • Ethanesulfonic acid,2-[[(3a,5b,7b)-3,7-dihydroxy-24-oxocholan-24-yl]aMino]-
  • Tauroursodeoxycholic acid dihydrate≥ 97% (Assay)
  • Sodium tauroursodeoxycholate≥ 98% (TLC)
  • 3α,7β-Dihydroxy-5β-cholan-24-oic acid n-(2-sulfoethyl)amide dihydrate
  • TUDCA/Tauroursodeoxycholic Acid powder
  • Taurous ursodeoxycholic acid
  • Tauroursodeoxycholic Acid-d4 (Tauroursodiol-d4)
  • Tauroursodeoxycholic-d5 Acid
  • Tauroursodeoxycholate acid
  • 3α,7β-Dihydroxy-5β-cholanoyltaurine
  • 9,10-secocholesta-5,7,10-trien-3-ol
  • Tauroursodeoxycholic-d4 Acid (Tauroursodiol-d4)
  • TAUROURSODEOXYCHOLIC ACID, SODIUM SALT (2,2,4,4-D4, 98%)
  • Tauroursodeoxycholic Dihydrate
  • Tauroursodeoxycholic Acid Standard
  • Ethanesulfonic acid, 2-[[(3α,5β,7β)-3,7-dihydroxy-24-oxocholan-24-yl]amino]-
  • TAUROURSODEOXYCHOLIC ACID, SODIUM SALT (2,2,4,4-D4, 98%) 100 UG/ML IN METHANOL
  • Potent Tudca Powder Ursodeoxycholic Acid
  • TAUROURSODEOXYCHOLIC ACID USP/EP/BP
  • TUDCA dihydrate
  • 2-[[(4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonic acid
  • TUDCA (TUD) (64)-1 gram
  • Tauroursodeoxycholic acidQ: What is Tauroursodeoxycholic acid Q: What is the CAS Number of Tauroursodeoxycholic acid Q: What is the storage condition of Tauroursodeoxycholic acid Q: What are the applications of Tauroursodeoxycholic acid
  • ursodeoxycholyltaurine
  • tauroursodeoxycholic acid sodium
  • Tauroursodeoxycholic acid-D4
  • TUDCA
  • Tauroursodeoxycholic Acid (TUDCA)
  • Taurolite
  • TUDCA Tauroursodeoxycholic Acid
  • Taursodeoxycholic acid
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