成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Aztreonam

Aztreonam Struktur
78110-38-0
CAS-Nr.
78110-38-0
Bezeichnung:
Aztreonam
Englisch Name:
Aztreonam
Synonyma:
AZACTAM;clobetasol propionate powder;monobactam;Aztreonam/arginine;[2S-[2A,3B(Z)]]-2-[[[1-(2-AMINO-4-THIAZOLYL)-2-[(2-METHYL-4-OXO-1-SULFO-3-AZETIDINYL)AMINO]-2-OXOETHYLIDENE]AMINO]OXY]-2-METHYLPROPANOIC ACID;Azonam;Aztreon;NSC1245;sq26,776;Nebactam
CBNumber:
CB0386184
Summenformel:
C13H17N5O8S2
Molgewicht:
435.43
MOL-Datei:
78110-38-0.mol

Aztreonam Eigenschaften

Schmelzpunkt:
227°C
Dichte
1.83
Brechungsindex
1.6460 (estimate)
storage temp. 
room temp
L?slichkeit
DMSO (Slightly), Water (Slightly, Heated, Sonicated)
Aggregatzustand
solid
pka
pKa -0.7(H2O t=RT Iunde?ned) (Uncertain);2.75(H3O t=RT Iunde?ned) (Uncertain);3.91(H4O t=RT Iunde?ned) (Uncertain)
Farbe
white to beige
Wasserl?slichkeit
Soluble in DMF/water (1:1) at 50 mg/ml
Merck 
14,925
InChIKey
WZPBZJONDBGPKJ-VEHQQRBSSA-N
SMILES
C(O)(=O)C(O/N=C(/C1=CSC(N)=N1)\C(N[C@@H]1C(=O)N(S(O)(=O)=O)[C@H]1C)=O)(C)C
CAS Datenbank
78110-38-0(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 20/21/22-36/37/38
S-S?tze: 22-24/25-36-26
WGK Germany  2
RTECS-Nr. UA2451400
HS Code  29419000
Toxizit?t TDLo ivn-rat: 1100 mg/kg (7-17D preg):TER NKRZAZ33(Suppl 1),203,85
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H334 Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen. Sensibilisierung der Atemwege Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" /> P261, P285, P304+P341, P342+P311,P501
H400 Sehr giftig für Wasserorganismen. Kurzfristig (akut) gew?ssergef?hrdend Kategorie 1 Warnung GHS hazard pictogramssrc="/GHS09.jpg" width="20" height="20" /> P273, P391, P501
Sicherheit
P261 Einatmen von Staub vermeiden.
P273 Freisetzung in die Umwelt vermeiden.
P285 Bei unzureichender Belüftung Atemschutz tragen.
P304+P341 BEI EINATMEN: Bei Atembeschwerden an die frische Luft bringen und in einer Position ruhigstellen, die das Atmen erleichtert
P342+P311 Bei Symptomen der Atemwege: GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P391 Verschüttete Mengen aufnehmen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Aztreonam Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

Aztreonam is the first member of the monobactam class of antibiotics to be introduced into the world market. It possesses high β-lactamase stability and moderately good activity against gram negative aerobes such as E. coli, S. marcescens, -9 Proteus Providencia, Salmonella, g. influenzae, E. gonorrhea, and &. pneumonia. While somewhat less potent against Pseudomonas aeruginosa, it is nonetheless one of the better β-lactams against this species. It has poor activity against gram positive organisms.

Chemische Eigenschaften

White Crystalline Powder

History

Aztreonam was synthesized by the Squibb Institute for Medical Research in 1981 starting with l-threonine. The synthesis was based on findings about bacterial β-lactam compounds of a monocyclic nature . The β-lactam compounds, called monobactams, were isolated from Chromobacterium violaceum, Agrobacterium radiobacter, etc. Such monocyclic βlactams of bacterial origin had previously been found independently in 1981 by Takeda Chemicals Industries in the culture broths of Pseudomonas acidophila and P. mesoacidophila and named sulfazecin and isosulfazecin, respectively. Aztreonam was selected from among hundreds of derivatives as a candidate for clinical trials because of its unique antibacterial spectrum and strong activity. This antibiotic shows excellent activity against a variety of gram-negative aerobic bacteria but no activity against gram-positive bacteria or anaerobes. Its efficacy and safety are now being clinically evaluated.

Verwenden

Aztreonam is a synthetic β-lactam antibiotic of the monobactam class. It is effective against Gram-negative bacteria but inactive against Gram-positive bacteria. Its mechanism of action involves the inhibition of mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking. Aztreonam is resistant to hydrolysis by some β-lactamases, but is inactivated by extended-spectrum β-lactamases.

Antimicrobial activity

Concentrations (mg/L) inhibiting 50% of other organisms are: Aeromonas spp., 0.1;Acinetobacter spp., 16; Mor. catarrhalis, 0.1; Burkholderia cepacia, 2; and Yersinia spp., 0.1. Synergy has been shown with gentamicin, tobramycin and amikacin against 52–89% of strains of Ps. aeruginosa and gentamicin-resistant Gram-negative bacteria.

Pharmakokinetik

Cmax 1 g intravenous: 90 mg/L end infusion
1 g intramuscular: 46 mg/L after 1 h
Plasma half-life: 1.7 h
Volume of distribution: 0.18 L/kg
Plasma protein binding: 56%
Absorption and distribution
Oral bioavailability is less than 1%. Peak concentrations above the median MIC for most Gram-negative pathogens are achieved in most tissues and body fluids after 1 g intramuscular or intravenous doses.
Metabolism and excretion
It is not extensively metabolized, the most prominent product, resulting from opening the β-lactam ring, being scarcely detectable in the serum and accounting for about 6% of the dose in the urine and 3% in the feces.
It is predominantly eliminated in the urine, where 58–72% appears within 8 h. Less than 12% is eliminated unchanged in the feces, suggesting low biliary excretion.

Clinical Use

Urinary tract infections, including pyelonephritis and cystitis
Lower respiratory tract infections, including pneumonia and bronchitis
caused by Gram-negative bacilli
Septicemia
Skin and skin structure infections, including postoperative wounds, ulcers
and burns
Intra-abdominal infections, including peritonitis
Gynecological infections, including endometritis and pelvic cellulitis

Nebenwirkungen

Local reactions occasionally occur at the injection site. Systemic reactions include diarrhea, nausea and/or vomiting and rash (1–1.3%). Neutropenia was seen in 11.3% of the pediatric patients younger than 2 years. Pseudomembranous colitis has been reported.
There are no reactions in patients with immunoglobulin E (IgE) antibodies to benzylpenicillin or penicillin moieties. It is rarely cross-reactive with other β-lactam antibiotics and is weakly immunogenic.

Sicherheitsprofil

Moderately toxic by severalroutes. An experimental teratogen. Other experimentalreproductive effects. When heated to decomposition itemits toxic fumes of NOx and SOx.

Aztreonam Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Aztreonam Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 537)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12835 58
Hebei Weibang Biotechnology Co., Ltd
+8617732866630
bess@weibangbio.com China 18151 58
Hangzhou Hyper Chemicals Limited
+86-0086-57187702781 +8613675893055
info@hyper-chem.com China 295 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3009 60
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3619 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58

78110-38-0(Aztreonam)Verwandte Suche:


  • Aztreonam L-Arginine
  • (E)-2-(((1-(2-aminothiazol-4-yl)-2-((2-methyl-4-oxo-1-sulfoazetidin-3-yl)amino)-2-oxoethylidene)amino)oxy)-2-methylpropanoic acid
  • Aztreonam(β-form)
  • Aztreonam94-103% (HPLC)
  • Aztreonam and Sodium Carbonate
  • (2s-(2-alpha,3-beta(z)))-dinyl)amino)-2-oxoethylidene)amino)oxy)-2-methyl
  • antibioticsquibb26,776
  • propanoicacid,2-(((1-(2-amino-4-thiazolyl)-2-((2-methyl-4-oxo-1-sulfo-3-azeti
  • sq26,776
  • Propanoic acid, 2-[[(Z)-[1-(2-amino-4-thiazolyl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfo-3-azetidinyl]amino]-2-oxoethylidene]amino]oxy]-2-methyl-
  • Propanoic acid, 2-[[[1-(2-amino-4-thiazolyl)-2-[(2-methyl-4-oxo-1-sulfo-3-azetidinyl)amino]-2-oxoethylidene]amino]oxy]-2-methyl-, [2S-[2α,3β(Z)]]-
  • Squibb 26776
  • Aztreonam, Azactam, Ayactam
  • [2S-[2a,3(Z)]]-2-[[(Z)-[1-(2-Amino-4-thiazolyl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfo-3-azetidinyl]amino]-2-oxoethylidene]amino]oxy]-2-methylpropanoic Acid
  • [2S-[2S-[2α,3β(Z)]]-2-[[[1-(2-Amino-4-thiazolyl)-2-[(2-methyl-4-oxo-1-sulfo-3-azetidinyl)amino]-2-oxoethylidene]amino]oxy]-2-methylpmpanoic acid
  • 2-[(2-Amino-Thiazol-4-Yl)-(2-Methyl-4-Oxo-1-Sulfo-Azetidin-3
  • Aztreonam,[2S-[2α,3β(Z)]]-2-[[[1-(2-Amino-4-thiazolyl)-2-[(2-methyl-4-oxo-1-sulfo-3-azetidinyl)amino]-2-oxoethylidene]amino]oxy]-2-methylpropanoic acid
  • Aztreonam (200 mg)
  • AztreonaM(AzactaM)
  • (2S,3S)-3-[(2E)-2-(2-azaniuMyl-1,3-thiazol-4-yl)-2-[(1-carboxy-1-Methylethoxy)iMino]acetaMido]-2-Methyl-4-oxoazetidine-1-sulfonate
  • AztreonaM(AzactaM, Cayston)
  • [2S-[2α,3β(Z)]]-2-[[(Z)-[1-(2-AMino-4-thiazolyl)-2-[[(2S,3S)-2-Methyl-4-oxo-1-sulfo-3-azetidinyl]aMino]-2-oxoethylidene]aMino]oxy]-2-Methylpropanoic Acid
  • 2-[[(Z)-[1-(2-Amino-4-thiazolyl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfo-3-azetidinyl]amino]-2-oxoethylidene]amino]oxy]-2-methylpropionic Acid
  • 2-((Z)-1-(2-aMinothiazol-4-yl)-2-((2S,3S)-2-Methyl-4-oxo-1-sulfoazetidin-3-ylaMino)-2-oxoethylideneaMinooxy)-2-Methylpropanoic acid
  • 2-[(2-AMINO-THIAZOL-4-YL)-(2-METHYL-4-OXO-1-SULFO-AZETIDIN-3-YLCARBAMOYL)-METHYLENEAMINOOXY]-2-METHYL-PROPIONIC ACID
  • 2-[[[(Z)-1-(2-AMINO-4-THIAZOLYL)-2-[[(2S,3S)-2-METHYL-4-OXO-1-SULFO-3-AZETIDINYL]AMINO]-2-OXOETHYLIDENE]AMINO]OXY]-2-METHYLPROPANOIC ACID
  • (2S-(2ALPHA,3BETA(Z)))-2-(((1-(2-AMINO-4-THIAZOLYL)-2-((2-METHYL-4-OXO-1-SULFO-3-AZETIDINYL)AMINO)-2-OXOETHYLIDENE)AMINO)OXY)-2-METHYL-PROPANOIC ACID
  • AZTHREONAM
  • AZTREONAM
  • AZTREONAM, E-ISOMER USP STANDARD
  • AZTREONAM, USP STANDARD
  • Azteronam
  • [2S-[2a,3b(Z)]]-2-[[(Z)-[1-(2-Amino-4-thiazolyl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfo-3-azetidinyl]amino]-2-oxoethylidene]amino]oxy]-2-methylpropanoic Acid
  • Aztreon
  • Nebactam
  • Squibb 2677
  • [2s-[2α,3β(z)]]-2-[[[1-(2-amino-4-thiazolyl)-2-[(2-methyl-4-oxo-1-sulfo-3-azetidinyl)amino]-2-oxoethylidene]amino]oxy]-2-methylpropanoic acid
  • (Z)-2-[[[(2-AMINO-4-AZTREONAM
  • {2S-[2a,3b(Z)]}-2-{[((2-amino-4-thiazolyl)-2-((2-methyl-4-oxo-1-sulfo-3-azetidinyl)amino)-2-oxoethyl
  • Azonam
  • Primbactam
  • Aztreonam for injection
  • 2S-[2a,3b(Z)]]-2-[[[1-(2-Amino-4-thiazolyl)-2-[(2-methyl-4-oxo-1-sulfo-3-azetidinyl)amino]-2-oxoethylidene]amino]oxy]-2-methylpropanoic acid
  • Aztreonam (Anhydrous)
  • Aztreonam/arginine mixing powder
  • Aztreonam Sterile powder
  • a-Form aztreonam
  • Aztrenom
  • Aztreonam,97%
  • (Z)-Anhydrous Aztreonam
  • 2-[(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-[[(2S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]amino]-2-oxoethylidene]amino]oxy-2-methylpropanoic acid
  • Aztreonam USP/EP/BP
  • 2-({[(2-amino-1,3-thiazol-4-yl)({[(2S,3S)-2-methyl-4 -oxo-1-sulfoazetidin-3-yl]carbamoyl})methylidene] amino}oxy)-2-methylpropanoic acid
  • treonam L-Arginine
  • Aztreonam (SQ-26776)
  • AztreonamQ: What is Aztreonam Q: What is the CAS Number of Aztreonam Q: What is the storage condition of Aztreonam Q: What are the applications of Aztreonam
  • α-Aztreonam
  • Sterile Grade Aztreonam API
Copyright 2019 ? ChemicalBook. All rights reserved