CFTRinh-172
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- CAS-Nr.
- 307510-92-5
- Englisch Name:
- CFTRinh-172
- Synonyma:
- CS-1067;CFTR(INH)-172;CFTR INHIBITOR-172;CFTRinh-172 USP/EP/BP;InSolution? CFTR Inhibitor-172;CFTR INHIBITOR-172;CFTRINH-172;CFTRinh 172 (CFTR Inhibitor-172);CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem;4-[[4-Oxo-2-Thioxo-3-[3-(Trifluoromethyl)Phenyl]Thiazolidin-;InSolution CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem
- CBNumber:
- CB0364629
- Summenformel:
- C18H10F3NO3S2
- Molgewicht:
- 409.4
- MOL-Datei:
- 307510-92-5.mol
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CFTRinh-172 Eigenschaften
- Schmelzpunkt:
- 181-183 °C
- Siedepunkt:
- 555.7±60.0 °C(Predicted)
- Dichte
- 1.61±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: ≥10mg/mL
- Aggregatzustand
- Yellow solid
- pka
- 3.88±0.10(Predicted)
- Farbe
- yellow
- CAS Datenbank
- 307510-92-5
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
 
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| H410 |
Sehr giftig für Wasserorganismen mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 1 |
Warnung |
![GHS hazard pictograms]() src="/GHS09.jpg" width="20" height="20" /> |
P273, P391, P501 |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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CFTRinh-172 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
The cystic fibrosis (CF) gene encodes a cAMP-regulated chloride channel, the CF transmembrane conductance regulator (CFTR). CFTR Inhibitor-172 is a thiazolidinone that selectively blocks the CFTR channel (Ki = 300 nM) in a voltage-independent manner. It appears to directly modulate the gating of chloride at the channel and does not prevent elevation of cAMP or inhibit other pumps or channels. In mice, CFTR inhibitor-172 prevents cholera toxin-induced fluid secretion in the small intestine, when given by intraperitoneal injection. It slows cyst growth in animal models of polycystic kidney disease. As CFTR also modulates glutathione (GSH) efflux, CFTR inhibitor-172 can affect intracellular GSH concentration and reactive oxygen species balance.
Definition
ChEBI: A thiazolidinone that is 2-thioxo-4-thiazolidinone which is substituted at position 3 by a (m--trifluoromethyl)phenyl group and at position 5 by a p-carboxybenzylidene group. It is an inhibitor of cystic fibrosis transmembrane con
uctance regulator, a membrane protein and chloride channel in vertebrates that is encoded by the CFTR gene.
Biologische Aktivit?t
Voltage-independent, selective CFTR chloride channel blocker (K i = 300 nM) that alters channel gating. Blocks intestinal fluid secretion induced by cholera toxin and Escherichia coli and suppresses cyst growth in animal models of polycystic kidney disease. Orally active. Inhibits mitochondrial respiration and increases reactive oxygen species (ROS) production independently of CFTR in several cell lines.
CFTRinh-172 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
CFTRinh-172 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 114)Lieferanten
307510-92-5()Verwandte Suche:
- 3-[(3-Trifluoromethyl)Phenyl]-5-[(4-Carboxyphenyl)Methylene]-2-Thioxo-4-Thiazolidinone
4-[(Z)-[4-Oxo-2-Sulfanylidene-3-[3-(Trifluoromethyl)Phenyl]-1,3-Thiazolidin-5-Ylidene]Methyl]Benzoic Acid
- 4-[[4-Oxo-2-Thioxo-3-[3-(Trifluoromethyl)Phenyl]Thiazolidin-
- InSolution? CFTR Inhibitor-172
- CFTR(INH)-172
- CFTR INHIBITOR-172
- 5-[(4-CARBOXYPHENYL)METHYLENE]-2-THIOXO-3-[(3-TRIFLUOROMETHYL)PHENYL-4-THIAZOLIDINONE]
- 3-[(3-TRIFLUOROMETHYL)PHENYL]-5-[(4-CARBOXYPHENYL)METHYLENE]-2-THIOXO-4-THIAZOLIDINONE
- 4-[4-OXO-2-THIOXO-3-(3TRIFLUOROMETHYL-PHENYL)-THIAZOLIDIN-5-YLIDENEMETHYL]-BENZOIC ACID (FOR R&D ONLY)
- 4-[[4-Oxo-2-thioxo-3-[3-trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]benzoicacid
- CFTRinh 172 (CFTR Inhibitor-172)
- Benzoic acid, 4-[[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]-
- 4-[[4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid
- CS-1067
- CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem
- InSolution CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem
- CFTR INHIBITOR-172;CFTRINH-172
- CFTRinh-172 USP/EP/BP
- 307510-92-5
- C18H10F3NO3S2
- Voltage-gated Ion Channels
- Chloride Channel Modulators
- Monovalent Ion Channels
- Ion Channels
- BioChemical
- Cell Biology
- Cell Signaling and Neuroscience
- Inhibitors
