Saikosaponin D
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- CAS-Nr.
- 20874-52-6
- Englisch Name:
- Saikosaponin D
- Synonyma:
- Saikoside d;saikosaponin;saikosaponins;SAIKOSAPONIN D;Saikosaponian D;SAILKOSAPONIN D;SAILKOSAPONINS D;Saikosaponin D(P);Saikosaponin D-RM;SAIKOSAPONIN D(RG)
- CBNumber:
- CB0329374
- Summenformel:
- C42H68O13
- Molgewicht:
- 780.99
- MOL-Datei:
- 20874-52-6.mol
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Saikosaponin D Eigenschaften
- Schmelzpunkt:
- 212～218℃
- Siedepunkt:
- 893.7±65.0 °C(Predicted)
- Dichte
- 1.36±0.1 g/cm3(Predicted)
- storage temp.
- Hygroscopic, Refrigerator, Under inert atmosphere
- L?slichkeit
- Methanol (Slightly), Pyridine (Slightly)
- Aggregatzustand
- Solid
- pka
- 12.83±0.70(Predicted)
- Farbe
- White to Off-White
- Stabilit?t:
- Hygroscopic
- LogP
- 3.756 (est)
- CAS Datenbank
- 20874-52-6
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| S-S?tze: |
24/25 |
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| RTECS-Nr. |
VN3099000 |
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| HS Code |
29389090 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P321 |
Besondere Behandlung |
| P332+P313 |
Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P362 |
Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen. |
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Saikosaponin D Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Saikosaponin D is a triterpene saponin found in Bupleurum that exhibits antioxidative, immunomodulatory, anti-fibrotic, anti-angiogenic, anticancer, and chemopreventive activities. Saikosaponin D increases activity of superoxide dismutase, catalase, and glutathione peroxidase and decreases activity of malondialdehyde in cellular models of oxidative damage. In other in vitro models, saikosaponin D increases secretion of IL-12, maturation of dendritic cells, and proliferation of lymphocytes. Saikosaponin D inhibits SERCA, increasing intracellular Ca2+ and inducing autophagy. In vivo, this compound decreases severity of fibrosis. In embryos, saikosaponin D decreases microvessel formation. Additionally, this compound decreases tumor formation in DEN-treated animal models and suppresses expression of CEBP-β and COX-2. Saikosaponin D also induces apoptosis and activation of caspases 3 and 7 in hepatocellular carcinoma cells. Saikosaponin D is a Glucocorticoid receptor agonist. It is a COX-2 and iNOS inhibitor.
Verwenden
Saikosaponin d (SSd) is an important active component of Bupleurum scorzonerifolium Willd., a traditional Chinese medicinal herb. Saikosaponins such as Saikosaponin D are used to help analyse and resolve the activities of herbal medicines such as Sho-saiko-to.
Biologische Aktivit?t
Saikosaponin D inhibits cell growth of human cancer cells by inducing apoptosis and blocking cell cycle progression in the G1 phase. Saikosaponin D was found to stimulate corticotropin-releasing factor (CRF) gene expression and CRF release.
Saikosaponin D Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Saikosaponin D Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 277)Lieferanten
20874-52-6()Verwandte Suche:
- (3b,4a,16a)-13,28-Epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-beta-D-glucopyranosyl beta-D-galactopyranoside
- SAIKOSAPONIN D
- saikosaponin
- saikosaponins
- Saikosaponian D
- SAIKOSAPONIN D 98+% BY HPLC
- SAILKOSAPONINS D
- Saikosaponin d std.
- SAILKOSAPONIN D
- SAIKOSAPONIN D(RG)
- Saikoside d
- SAIKOSAPONIN B2(P)
- Saikosaponin D, 98%, from Bupleurum chinense DC.
- Saikosaponin D 20874-52-6
- b-D-Galactopyranoside, (3b,4a,16a)-13,28-epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-b-D-glucopyranosyl-
- Bupleurum saikosaponin D
- β-D-Galactopyranoside, (3β,4α,16α)-13,28-epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-β-D-glucopyranosyl-
- (2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-3,5-Dihydroxy-2-(((3S,4R,4aR,6aR,6bS,8R,8aS,12aR,12bS,14aR,14bS)-8-hydroxy-4-(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,9,10,11,12,12a,14a,14b-octadecahydro-12b,8a-(epoxymethano)picen-3-yl)oxy)-6-methyltetrahydro-2H-pyran-4-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
- Saikosaponin D(P)
- Saikosaponin D-RM
- 20874-52-6
- 20736-52-6
- C48H78O18
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Aromatic Phenols
