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Estradiolvalerat

Estradiol valerate  Struktur
979-32-8
CAS-Nr.
979-32-8
Bezeichnung:
Estradiolvalerat
Englisch Name:
Estradiol valerate
Synonyma:
delestrogen;β-Estradiol 17-valerate;Nuvelle;femogex;pharlon;estraval;Climaval;Valergen;deladiol;atladiol
CBNumber:
CB0300193
Summenformel:
C23H32O3
Molgewicht:
356.51
MOL-Datei:
979-32-8.mol

Estradiolvalerat Eigenschaften

Schmelzpunkt:
144°C
Siedepunkt:
438.83°C (rough estimate)
Dichte
1.1024 (rough estimate)
Brechungsindex
1.4700 (estimate)
storage temp. 
Sealed in dry,Room Temperature
L?slichkeit
Practically insoluble in water, soluble in alcohol.
pka
10.25±0.60(Predicted)
Aggregatzustand
Solid
Farbe
White to off-white
Merck 
13,3738
BRN 
2480357
InChI
InChI=1/C23H32O3/c1-3-4-5-22(25)26-21-11-10-20-19-8-6-15-14-16(24)7-9-17(15)18(19)12-13-23(20,21)2/h7,9,14,18-21,24H,3-6,8,10-13H2,1-2H3/t18-,19-,20+,21+,23+/s3
InChIKey
RSEPBGGWRJCQGY-RBRWEJTLSA-N
SMILES
C[C@]12CC[C@]3([H])C4C=CC(O)=CC=4CC[C@@]3([H])[C@]1([H])CC[C@@H]2OC(=O)CCCC |&1:1,4,15,17,21,r|
CAS Datenbank
979-32-8(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T
R-S?tze: 60-61
S-S?tze: 53-45
WGK Germany  3
RTECS-Nr. KG5793000
HS Code  29372390
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H351 Kann vermutlich Krebs verursachen. Karzinogenit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
H362 Kann S?uglinge über die Muttermilch sch?digen. Reproductive toxicity, effects on or via lactation Additional category P201, P260, P263, P264, P270,P308+P313
H410 Sehr giftig für Wasserorganismen mit langfristiger Wirkung. Langfristig (chronisch) gew?ssergef?hrdend Kategorie 1 Warnung GHS hazard pictogramssrc="/GHS09.jpg" width="20" height="20" /> P273, P391, P501
Sicherheit
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P263 Kontakt w?hrend der Schwangerschaft /und der Stillzeit vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P273 Freisetzung in die Umwelt vermeiden.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Estradiolvalerat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R60:Kann die Fortpflanzungsf?higkeit beeintr?chtigen.
R61:Kann das Kind im Mutterleib sch?digen.

S-S?tze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Beschreibung

Estradiol valerate (EV), sold for use by mouth under the brand name Progynova and for use by injection under the brand names Delestrogen and Progynon Depot among others, is an estrogen medication. In women, it is used in hormone therapy for menopausal symptoms and low estrogen levels, hormone therapy for transgender women, and in hormonal birth control. It is also used in the treatment of prostate cancer in men. The medication is taken by mouth or by injection into muscle or fat once every 1 to 4 weeks.

Chemische Eigenschaften

White to off-white crystalline powder, odorless. Insoluble in water, easily soluble in ethanol, acetone, chloroform, slightly soluble in vegetable oil.

Verwenden

Estradiol valerate is a female hormone (estrogen). It is used to reduce symptoms of menopause which are vaginal dryness, hot flashes, and others. The symptoms of menopause manifest because the body is making less estrogen; with estradiol valerate, these symptoms are brought to the lowest minimum. This medication therapy can also produce enough estrogen in women with ovarian failure, hypogonadism and can be used by men to treat prostate cancer (palliation only).

Definition

ChEBI: Estradiol valerate is a steroid ester. It is the parenterally-administered synthetic valerate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females.

Indications

Estradiol valerate is commercially available as an intramuscular injection as the product Delestrogen and is indicated for the treatment of moderate to severe vasomotor symptoms and vulvovaginal atrophy due to menopause, for the treatment of hypoestrogenism due to hypogonadism, castration or primary ovarian failure, and for the treatment of advanced androgen-dependent carcinoma of the prostate (for palliation only). Estradiol valerate is also available in combination with Dienogest as the commercially available product Natazia used for the prevention of pregnancy and for the treatment of heavy menstrual bleeding.

Allgemeine Beschreibung

Estradiol valerate is a synthetic hormone that is extensively metabolized to estradiol and valeric acid before reaching the systemic circulation. It is well suited for treatment of the characteristic symptoms accompanying menopause in women.

Nebenwirkungen

As with all pharmaceutical medicines, some unwanted effects can occur from the use of estradiol valerate tablets.
Always consult a physician for medical advice before use.
Common side effects may include: bloating, vomiting, nausea, breast tenderness, headache, weight changes, and mood changes.
More severe side effects may include mental changes, breast lumps, vaginal bleeding, liver damage, increased thirst, and sudden vision loss.

Sicherheitsprofil

Suspected carcinogen with carcinogenic and teratogenic data. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTRADIOL.

Estradiolvalerat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Estradiolvalerat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 426)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Bonster Technology Co.,Limited
+8613315996897
bsterltd.wendy@gmail.com China 792 58
Anhui Yiao New Material Technology Co., Ltd
+86-18033737140 +86-17354101231
sales1@hbganmiao.com China 227 58
Lewoo Pharmatech(Shanghai)Co.,Ltd
+86-15800805830 +86-15800805830
miao@lewoopharma.com.cn China 184 58
Hebei Lingding Biotechnology Co., Ltd.
+86-18031140164 +86-19933155420
erin@hbldbiotech.com China 58 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-81148696 +86-15536356810
1022@dideu.com China 3882 58
Hong Kong Excellence Biotechnology Co., Ltd.

ada@sh-teruiop.com China 875 58
Wuhan Haorong Biotechnology Co.,ltd
+86-18565342920; +8618565342920
sales@chembj.net China 289 58
Anhui Ruihan Technology Co., Ltd
+8617756083858
daisy@anhuiruihan.com China 973 58
Nantong Guangyuan Chemicl Co,Ltd
+undefined17712220823
admin@guyunchem.com China 615 58
Hebei Kangcang new material Technology Co., LTD
+8615713292910
Nancy@kangcang.com.cn China 341 58

979-32-8(Estradiolvalerat)Verwandte Suche:


  • delestrogen4x
  • dura-estradiol
  • estradiol17-beta-valerate
  • estradiolvalerianate
  • estraval
  • 17BETA-ESTRADIOL VALERATE
  • 17B-ESTRADIOL-17-VALERATE
  • 17B-ESTRADIOL VALERATE
  • 17-BETA-ESTRADIOL 17-VALERATE
  • 17BETA-ESTRADIOL 17-VALERATE VETRANAL, 2
  • Estra-1,3,5(10)-triene-3,17-diol (17.beta.)-, 17-pentanoate
  • 1,3,5(10)-estratriene-3,17β-diol 17-pentanote
  • ESTRADIOLVALERATE,USP
  • Estrdiol Valerate
  • ESTRADIOL VALEATE
  • 3-Hydroxy-17β-valeroyloxyestra-1,3,5(10)-triene
  • Climaval
  • Estra-1,3,5(10)-triene-3,17-diol (17β)-, 17-pentanoate
  • Estra-1,3,5(10)-triene-3,17β-diol 17-valerate
  • Estradiol valerate (6CI)
  • Estradiol, 17-valerate (7CI, 8CI)
  • Gynogen LA
  • Gynogen LA 40
  • NSC 17590
  • Nuvelle
  • Oestradiol valerinate
  • Pelanin Depot
  • Primofol-Depot
  • Primogyn-Depot
  • Valergen
  • OESTRADIOL-17BETA-VALERATE
  • 1,3,5(10)-Estratriene-3,17b-diol 17-pentanote
  • Estradiol-17-valerate
  • BETA-ESTRADIOL 17-VALERATE
  • DIHYDROFOLLICULIN VALERATE
  • ESTRADIOL VALERATE
  • [(8R,9S,13S,14S,17S)-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] pentanoate
  • valeric acid [(8R,9S,13S,14S,17S)-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] ester
  • ESTRADIOL-17-VALERATE, 17B-(RG)
  • deladiol
  • delahormoneunimatic
  • femogex
  • neofollin
  • oestradiolvalerate
  • pharlon
  • progynon-depot
  • progynova
  • 1,3,5(10)-ESTRATRIENE-3,17BETA-DIOL 17-PENTANOATE
  • 1,3,5[10]-ESTRATRIENE-3,17BETA-DIOL 17-VALERATE
  • 1,3,5(10)-ESTRATRIEN-3,17-BETA-DIOL 17-VALERATE
  • 1,3,5(10)-ESTRATRIEN-3,17B-DIOL-17-VALERATE
  • Estradiol Valerate (100 mg)
  • (8R,9S,13S,14S,17S)-3-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl pentanoate
  • β-Estradiol 17-valerate, >=99%
  • Estradiol valerate for system suitability
  • 3,5(10)-triene-3,17-diol(17-beta)-estra-17-pentanoate
  • atladiol
  • b-estradiol17-valerate
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