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Ethinylestradiol

Ethinyl Estradiol Struktur
57-63-6
CAS-Nr.
57-63-6
Bezeichnung:
Ethinylestradiol
Englisch Name:
Ethinyl Estradiol
Synonyma:
ETHINYL ESTRADIOL;ETHYNYLESTRADIOL;17α-Ethynylestradiol;Estradio;17a-ethinylestradiol;17ALPHA-ETHYNYLESTRADIOL;(8R,9S,13S,14S,17R)-17-ethynyl-13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol;eed;17-Ethinylestradiol;LYNORAL
CBNumber:
CB1350377
Summenformel:
C20H24O2
Molgewicht:
296.41
MOL-Datei:
57-63-6.mol

Ethinylestradiol Eigenschaften

Schmelzpunkt:
182-183 °C(lit.)
Siedepunkt:
378°C (rough estimate)
Dichte
1.0944 (rough estimate)
Brechungsindex
-30 ° (C=0.4, Pyridine)
Flammpunkt:
9℃
storage temp. 
room temp
L?slichkeit
ethanol: 50 mg/mL, clear, slightly yellow
pka
pKa 10.32 (Uncertain)
Aggregatzustand
Solid
Farbe
White to Light yellow to Light orange
Merck 
14,3734
BRN 
2419975
BCS Class
3/1
InChIKey
BFPYWIDHMRZLRN-SLHNCBLASA-N
CAS Datenbank
57-63-6(CAS DataBase Reference)
NIST chemische Informationen
Ethinyl estradiol(57-63-6)
EPA chemische Informationen
Ethinyl estradiol (57-63-6)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T,F
R-S?tze: 45-22-39/23/24/25-23/24/25-11
S-S?tze: 53-36/37/39-45-36/37-16
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
RTECS-Nr. RC8925000
8
HS Code  29372390
Giftige Stoffe Daten 57-63-6(Hazardous Substances Data)
Toxizit?t LD50 oral in rat: 960mg/kg
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H350 Kann Krebs verursachen. Karzinogenit?t Kategorie 1A Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" />
H410 Sehr giftig für Wasserorganismen mit langfristiger Wirkung. Langfristig (chronisch) gew?ssergef?hrdend Kategorie 1 Warnung GHS hazard pictogramssrc="/GHS09.jpg" width="20" height="20" /> P273, P391, P501
Sicherheit
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P273 Freisetzung in die Umwelt vermeiden.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Ethinylestradiol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R45:Kann Krebs erzeugen.
R22:Gesundheitssch?dlich beim Verschlucken.

S-S?tze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Beschreibung

Estrogens direct the development of the female genotype in embryogenesis and at puberty. Estradiol is the major estrogen secreted by the premenopausal ovary. Ethynyl estradiol is a synthetic analog of 17β-estradiol . A USP-approved grade of ethynyl estradiol is often formulated in combination with a progestin such as norgestrel /levonorgestrel or desogestrel and provided for use as an oral contraceptive. Efficacy of oral administration of ethynyl estradiol is facilitated by the ethynyl substitution at the C-17 position, which inhibits first pass hepatic metabolism. Ethynyl estradiol is also rapidly and almost completely absorbed from the gastrointestinal tract.

Chemische Eigenschaften

Off-White to Light-Yellow Crystalline Powder

Verwenden

A metabolite of 17a-Ethynylestradiol

Definition

ChEBI: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.

Allgemeine Beschreibung

Fine white to creamy white powder. A synthetic steroid. Used in combination with progestogen as an oral contraceptive.

Air & Water Reaktionen

Air and light sensitive . Insoluble in water.

Reaktivit?t anzeigen

Ethynyl estradiol may react vigorously with strong oxidizing agents. May react exothermically with reducing agents to generate gaseous hydrogen.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition Ethynyl estradiol emits acrid smoke and fumes.

Brandgefahr

The flash point data for Ethynyl estradiol are not available. Ethynyl estradiol is probably combustible.

Mechanism of action

Synthetic estrogen with potent activity (inhibition of ovulation), widely used in oral contraceptives. Manufactured from natural estrogen, estrone, by reaction with potassium acetylide (HCRCK) in liquid ammonia. The synthetic 17α-ethynyl derivative of estradiol-17β. The 17α-ethynyl group increases the in vivo potency of estradiol- 17β by blocking the action of 17β-dehydrogenase, a major pathway of estradiol-17β metabolic inactivation. It is thus active orally and is among the most potent of the known estrogenic compounds.

Sicherheitsprofil

Confirmed carcinogen with experimental carcinogenic, tumorigenic, and neoplastigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Human systemic effects by ingestion: glandular effects. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTRADIOL

m?gliche Exposition

The working environment may be contaminated during sex hormone manufacture, especially during the extraction and purification of natural steroid hormones; grinding of raw materials; handling of powdered products and recrystallization. Airborne particles of sex hormones may be absorbed through the skin, ingested or inhaled. Enteric absorption results in quick inactivation of sex hormones in the liver. The rate of inactivation is decreased for the oral, alkylated steroid hormones (methyl testosterone, anabolic steroids, etc.). Sex hormones may accumulate and reach relatively high levels even if their absorption is intermittent. Consequently, repeated absorption of small amounts may be detrimental to health. Intoxication by sex hormones may occur in almost all the exposed workers if preventive measures are not taken. The effect in the industrial sector is more successful than the agricultural one (chemical caponizing of cockerels by stilbestrol implants and incorporation of estrogens in feed for body weight gain promotion in beef cattle), where measures taken are summary and the number of cases of intoxication is consequently bigger

Versand/Shipping

UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials

l?uterung methode

17--Ethynylestradiol forms a hemihydrate on recrystallising from MeOH/H2O. It dehydrates on melting and remelts on further heating at m 182-184o. The UV has max at 281nm ( 2040) in EtOH. Its solubility is 17% in EtOH, 25% in Et2O, 20% in Me2CO, 25% in dioxane and 5% in CHCl3. [Petit & Muller Bull Soc Chim Fr 121 1951.] The diacetyl derivative has m 143-144o (from MeOH) and [] D 20 +1o (c 1, CHCl3) [Mills et al. J Am Chem Soc 80 6118 1958]. [Beilstein 6 IV 6877.]

Inkompatibilit?ten

May react exothermically with reducing agents to generate flammable gaseous hydrogen. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, and epoxides.

Waste disposal

It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator

Ethinylestradiol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Ethinylestradiol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 549)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Wuhan Han Sheng New Material Technology Co.,Ltd
+8617798174412
admin01@hsnm.com.cn China 2097 58
airuikechemical co., ltd.
+undefined86-15315557071
sales02@sdzhonghuimaterial.com China 983 58
Dorne Chemical Technology co. LTD
+86-86-13583358881 +8618560316533
Ethan@dornechem.com China 3106 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971
deasea125996@gmail.com China 2472 58
Wuhan Haorong Biotechnology Co.,ltd
+86-18565342920; +8618565342920
sales@chembj.net China 289 58
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +8617865335152
Mandy@hangyubiotech.com China 10986 58
Nantong Guangyuan Chemicl Co,Ltd
+undefined17712220823
admin@guyunchem.com China 615 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20288 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
+86-18600796368 +86-18600796368
sales@sjar-tech.com China 375 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
sales01@cooperate-pharm.com CHINA 1803 55

57-63-6(Ethinylestradiol)Verwandte Suche:


  • 19-NORPREGNA-1,3,5(10)-TRIEN-20-YNE-3,17ALPHA-DIOL
  • 19-NOR-1,3,5[10],17ALPHA-PREGNATRIEN-20-YNE-3,17-DIOL
  • 1,3,5(10)-ESTRATRIEN-17-ALPHA-ETHYNYL-3,17-BETA-DIOL
  • ACETENYL ESTRADIOL
  • 17ALPHA-ETHYNYL-DELTA1,3,5(10)-ESTRA-TRIENE-3,17BETA-DIOL
  • 17-ALPHA-ETHYNLESTRADIOL
  • 17ALPHA-ETHYNYL-1,3,5[10]-ESTRATRIENE-3,17BETA-DIOL
  • 17a-ethynyl-1,3,5(10)-estratriene-3,17b-diol
  • 17 A-ETHYNYLESTRADIOL
  • 17alpha-ethinylestra-1,3,5(10)-triene-3,17beta-diol
  • (17-alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17,diol
  • 17-alpha-ethinyl-17-beta-estradiol
  • 17alpha-Ethinyl-17beta-estradiol
  • 17alpha-Ethinyl-3,17-dihydroxy-delta(sup1,3,5)-estratriene
  • 17alpha-ethinyl-3,17-dihydroxy-delta(sup1,3,5)oestratriene
  • 17alpha-ethinyl-delta(sup1,3,5(10))oestratriene-3,17-beta -diol
  • 17-alpha-ethinyl-delta(sup1,3,5(10))oestratriene-3,17-beta-diol
  • 17-alpha-ethinylestra-1,3,5(10)-triene-3,17-beta-diol
  • NOVESTROL
  • NEO-ESTRONE
  • 17A-ETHYNYLESTRADIOL VETRANAL, 250 MG
  • (1S,10R,11S,14S,15S)-14-ethynyl-15-Methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-triene-5,14-diol
  • Ethinylestradiol Solution, 100ppm
  • 17α-Ethynylestradiol solution
  • Ethinylestradiol Imp.(EP)
  • Ethinylestradio
  • (8R,9S,13S,14S)-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
  • 17alpha-ethynyl-3,17-dihydroxy-delta-(sup1,3,5)-estratriene
  • 17alpha-Ethynyl-3-hydroxy-1,3,5(10)-estratrien-17beta-ol
  • estroals
  • primogyn c(or m)
  • roldiol
  • Quinestriol
  • 19-Nor-17alpha-pregna-1,3,5(10)-trien-20-yne-3,17-diol
  • 19-nor-17-alpha-pregna-1,3,5(10)-triene-20-yne-3,17-diol
  • 19Nor-17-pregna-1,3,5-(10)-trien-20yne-3,17-diol
  • diprol
  • Dyloform
  • ee(sub2)
  • Ertonyl
  • Esteed
  • Estigyn
  • Estoral
  • Estoral (orion)
  • estoral(orion)
  • Estorals
  • Estra-1,3,5(10)-triene-3,17beta-diol, 17alpha-ethynyl-
  • Estra-1,3,5(10)-triene-3,17beta-diol, 17-ethynyl-
  • Estradiol, 17-ethynyl-
  • estradiol,17-ethynyl-
  • Ethidol
  • Ethinoral
  • Ethinylestriol
  • ethinyloestriol
  • ethynyloestradiol
  • Eticyclin
  • Eticyclol
  • Eticylol
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