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PHA 767491 HYDROCHLORIDE

PHA 767491 HYDROCHLORIDE Struktur
845714-00-3
CAS-Nr.
845714-00-3
Englisch Name:
PHA 767491 HYDROCHLORIDE
Synonyma:
CS-229;CAY10572;PHA-767491;PHA-767491HCL;CAY10572(PHA-767491);PHA 767491;PHA-767491;PHA-767491 (CAY10572);PHA 767491 HYDROCHLORIDE;PHA 767491 HYDROCHLORIDE USP/EP/BP;PHA-767491;CAY10572;PHA767491;PHA 767491
CBNumber:
CB02458643
Summenformel:
C12H11N3O
Molgewicht:
213.24
MOL-Datei:
845714-00-3.mol

PHA 767491 HYDROCHLORIDE Eigenschaften

Dichte
1.287
storage temp. 
Desiccate at RT
L?slichkeit
insoluble in H2O; insoluble in EtOH; ≥10.65 mg/mL in DMSO
Aggregatzustand
solid
Stabilit?t:
Hygroscopic
CAS Datenbank
845714-00-3

Sicherheit

PHA 767491 HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Cdc7 kinase is a key regulator of the S-phase of the cell cycle. It is known to promote the activity of DNA replication origins in eukaryotic organisms. Inhibition of Cdc7 kinase causes blockade of DNA synthesis in human cell lines. Tumor cells are then funneled into the apoptotic pathway in a p53-independent manner. Pharmacological inhibition of Cdc7 kinase can be an effective strategy for the development of oncologic therapeutics useful for treatment of cancers. PHA 767491 HYDROCHLORIDE is a potent inhibitor of Cdc7 kinase with an IC50 value of 10 nM in the presence of 1.5 μM ATP. At 10 μM, PHA 767491 HYDROCHLORIDE induces apoptotic cell death in multiple cancer cell types. PHA 767491 HYDROCHLORIDE also inhibits Cdk9, a kinase involved in the phosphorylation of RNA polymerase II and in transcriptional regulation of gene expression, with an IC50 value of 34 nM.[Cayman Chemical]

Biologische Aktivit?t

Potent, ATP-competitive dual cdc7/cdk9 inhibitor (IC 50 values are 10 and 34 nM respectively) that prevents initiation of DNA replication. Inhibits cell proliferation in a variety of human cell lines (IC 50 ~ 0.86 - 5.87 μ M) and induces apoptosis in a p53-independent manner in vivo . Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK-2) (IC 50 = 171 nM).

PHA 767491 HYDROCHLORIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


PHA 767491 HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 97)Lieferanten
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ATK CHEMICAL COMPANY LIMITED
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Nantong HI-FUTURE Biology Co., Ltd.
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TargetMol Chemicals Inc.

support@targetmol.com United States 38631 58

  • PHA-767491
  • CAY10572
  • 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one
  • PHA 767491 HYDROCHLORIDE
  • 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-onehydrochloride
  • 2-(pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one
  • 2-pyridin-4-yl-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one
  • PHA-767491HCL
  • PHA-767491;CAY10572;PHA767491;PHA 767491
  • PHA-767491 (CAY10572)
  • PHA 767491;PHA-767491
  • CS-229
  • CAY10572(PHA-767491)
  • 4H-Pyrrolo[3,2-c]pyridin-4-one, 1,5,6,7-tetrahydro-2-(4-pyridinyl)-
  • PHA 767491 HYDROCHLORIDE USP/EP/BP
  • PHA-767491 PHA767491 Dihydrochloride Salt
  • 845714-00-3
  • C12H11N3OHCl
  • Inhibitors
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