NVP-TAE684
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- CAS-Nr.
- 761439-42-3
- Englisch Name:
- NVP-TAE684
- Synonyma:
- TAE684;NV--TAE684;NVP-TAE 684;NV--TAE684cas;TAE684 (NVP-TAE684);NVP-TAE684 - TAE 684;NVP-TAE684, ALK inhibitor;TAE684 (NVP-TAE684);NVP-TAE684;NVP-TAE684 - TAE 684 USP/EP/BP;5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin
- CBNumber:
- CB02446156
- Summenformel:
- C30H40ClN7O3S
- Molgewicht:
- 614.2
- MOL-Datei:
- 761439-42-3.mol
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NVP-TAE684 Eigenschaften
- Schmelzpunkt:
- 166-169°C
- Siedepunkt:
- 791.0±70.0 °C(Predicted)
- Dichte
- 1.296
- storage temp.
- Refrigerator, under inert atmosphere
- L?slichkeit
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
- Aggregatzustand
- Solid
- pka
- 8.14±0.42(Predicted)
- Farbe
- White to Pale Yellow
- CAS Datenbank
- 761439-42-3
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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NVP-TAE684 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Human anaplastic lymphoma kinase (ALK) is an oncogene that is amplified in neuroblastomas and when juxtaposed with various fusion partners, its constitutive kinase activity is associated with the development of a type of anaplastic large cell lymphoma (ALCL). NVP-TAE684 is an ALK inhibitor that blocks the proliferation of ALCL-derived and ALK-dependent cell lines with IC50 values of 2-5 nM. When tested against a panel of 35 cells transformed by various tyrosine kinases, TAE684 demonstrated 100- to 1,000-fold selectivity for inhibiting ALK-driven cell proliferation. NVP-TAE684 treatment induces cell cycle arrest and apoptosis in ALK-dependent cell lines and has been used to suppress tumor growth in in vivo models of ALK-positive ALCL and neuroblastoma. NVP-TAE684 is also reported to inhibit the activity of the Parkinson’s disease-linked leucine-rich repeat kinase 2 (IC50s = 7.8 and 6.1 nM for wild-type and G2019S mutant LRRK2, respectively).[Cayman Chemical]
IC 50
ALK IC50 = 0.15 nM
NVP-TAE684 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
NVP-TAE684 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 156)Lieferanten
761439-42-3()Verwandte Suche:
- NVP-TAE684 - TAE 684
- 5-Chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-pyrimidinediamine
- NVP-TAE 684
- 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine
- 5-Chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-pyrimidinediamine TAE684 (NVP-TAE684)
- NVP-TAE684
5-Chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-pyrimidinediamine
- 2,4-Pyrimidinediamine, 5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-
- TAE684 (NVP-TAE684)
- TAE684
- NV--TAE684
- 5-chloro-N~2~-{2-Methoxy-4-[4-(4-Methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N~4~-[2-(propan-2-ylsulfonyl)phenyl]pyriMidine-2,4-diaMine
- TAE684 (NVP-TAE684);NVP-TAE684
- 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin
- NV--TAE684cas
- NVP-TAE684 - TAE 684 USP/EP/BP
- 5-CHLORO-2-N-{2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]PHENYL}-4-N-[2-(PROPANE-2-SULFONYL)PHENYL]PYRIMIDINE-2,4-DIAMINE
- NVP-TAE684, ALK inhibitor
- 761439-42-3
- C30H40ClN7O3S
- Inhibitors
- API
