Candesartan
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- CAS-Nr.
- 139481-59-7
- Englisch Name:
- Candesartan
- Synonyma:
- Atacend;CV-11974;CILEXITIL;CANDESARTAN;tandishatan;Candesartan M1;Candesartan 98%;Candesartan Base;Candesartan (C8);Candesartan (Atacand)
- CBNumber:
- CB0209324
- Summenformel:
- C24H20N6O3
- Molgewicht:
- 440.45
- MOL-Datei:
- 139481-59-7.mol
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Candesartan Eigenschaften
- Schmelzpunkt:
- 183-185°C
- Siedepunkt:
- 754.8±70.0 °C(Predicted)
- Dichte
- 1.41±0.1 g/cm3(Predicted)
- RTECS-Nr.
- DD6671000
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- Soluble in DMSO (up to 40 mg/ml)
- Aggregatzustand
- solid
- pka
- 2.06±0.10(Predicted)
- Farbe
- White
- Wasserl?slichkeit
- Soluble in ethyl acetate, methanol, water (<1 mg/ml at 25°C), DMSO (88 mg/ml at 25°C), and ethanol (1 mg/ml at 25°C).
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
- CAS Datenbank
- 139481-59-7(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H312 |
Gesundheitssch?dlich bei Hautkontakt. |
Akute Toxizit?t dermal |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P280,P302+P352, P312, P322, P363,P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H332 |
Gesundheitssch?dlich bei Einatmen. |
Akute Toxizit?t inhalativ |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P271, P304+P340, P312 |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P304+P340 |
BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P405 |
Unter Verschluss aufbewahren. |
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Candesartan Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Crystalline Solid
Verwenden
Candesartan is a selective AT1 (angiotensin II receptor 1) antagonist. Antagonism of angiotensin receptors inhibits vasoconstriction and the production of aldosterone, leading to a decrease in water and sodium concentration in blood plasma. Exhibits antihypertensive effects in animal models. Used in treatment of congestive heart failure, as antihypertensive. Candesartan does not affect cell viability or proliferation but increases the expression of VEGF and interleukin-8 in the cultured medium of KU-19-19 cells. Candesartan (0.1 nM) could reduce the maximal contractile response to angiostensin II by approximately 50%.
Definition
ChEBI: A benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin
eceptor antagonist used for the treatment of hypertension.
Allgemeine Beschreibung
Candesartan, (+)-1-[[(cyclohexyloxy)carbonyl]-oxy]ethyl 2- ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylate(Atacand), like losartan, possesses the acidic tetrazole system,which most likely plays a role in binding to the angiotensin IIreceptor similarly to the acidic groups of angiotensin II. Also,the imidazole system has been replaced with a benzimidazolepossessing an ester at position. This ester must be hydrolyzedto the free acid. Fortunately, this conversion takesplace fairly easily because of the carbonate in the ester sidechain. This facilitates hydrolysis of the ester so much thatconversion to the free acid takes place during absorption fromthe gastrointestinal tract.
Candesartan Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Candesartan Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 504)Lieferanten
139481-59-7()Verwandte Suche:
- 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-2-ethoxy-1H-benzo[d]iMidazole-7-carboxylic acid
- 2-ethoxy-3-[[4-[2-(1h-tetrazol-5-yl)phenyl]phenyl]methyl]-3h-benzoimidazole-4-carboxylic acid
- 3-[[2'-(1H-Tetrazol-5-yl)biphenyl-4-yl]Methyl]-2-ethoxy-3H-benziMidazole-4-
carboxylic Acid
- Candesartan M1
- 2-ETHOXY1-2(1H-TETRAZOL-5YL)1,1-BIPHENYL)-4-YL)-4-YL)METHYL)1H-BENZIMIDAZOLE-7-CARBOXYLIC ACID
- Candesartan Cilexetil EP IMpurity G
- 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic
- 1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
- 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxy
- Candesartan Base
- 2-ETHOXY-1-[[2'-(1H-TETRAZOL-5-YL)(1,1'-BIPHENYL)-4-YL]METHYL]-1H-BENZIMIDAZOLE-7-CARBOXYLIC ACID
- Candesartan[CandesartanCilexetilIntermediates]
- Candesartan ( For Candesartan Cilexetil )
- CANDESARTAN
- CV-11974
- CILEXITIL
- 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic Acid, CV-11974
- 2-Ethoxy-1-[2'-(1-triphenylmethyltetrazol-5-yl)-biphenyl-4-yl-methyl]benzimidazole-7-carboxylicacidcyclohexyl-1-chloroethylcarbonate
- 2-ethoxy-1-[[(2-(1Htetrazol-5-yl)biphenyl-4-yl-) methyl]
- 2-Ethoxy-3-[[4-[2-(1H-tetrazol-5-yl)phenyl]phenyl]
- Atacend
- 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazol-7-carboxylic acid
- (±)-2-Ethoxy-1-[[2’-(1H-tetrazol-5-y1)[1，l'-biphenyl]-4-y1]methyl]-1H-benzimidazole-7-earboxylic acid
- 3-(2'-Cyano-biphenyl-4-ylMethyl)-2-ethoxy-3H-benzoiMidazole-4-carboxylic acid Me
- 2-ethoxy-1-({4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}Methyl)-1H-1,3-benzodiazole-7-carboxylic acid
- Candesartan (Atacand)
- Candesartan 98%
- Candesartan (Candesartan Cilexetil impurity G)
- Candesartan Solution, 1000ppm
- Candesartan Cilexetil Impurity 7(EP Impurity G)
- Candesartan Solution, 100ppm
- tandishatan
- Candesartan Cilexetil EP Impurity G(Candesartan)
- 2-Ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid
- 2-Ethoxy-1-[[(2′-(1Htetrazol-5-Yl)Biphenyl-4-Yl-) Methyl]Benzimidazole-7-Carboxylic Acid
- Candesartan (C8)
- 1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid
- Candesartan USP/EP/BP
- Cesartan intermediates
- Candesartan EP Impurity G
- Candesartan Cilexetil EP Impurity G (Candesartan Acid)
- Candesartan Impurity -G Candesartan Cilexetil EP Impurity G
- High Quality Intermediates Candesartan CAS: 139481-59-7
- Candesartan (CV 11974)
- candesartan cilexetil impurity1364
- CandesartanQ: What is
Candesartan Q: What is the CAS Number of
Candesartan Q: What is the storage condition of
Candesartan Q: What are the applications of
Candesartan
- Candesartan Cilexetil Related Compound G (1-{[2''-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-2-ethoxybe (1087870)
- Candesartan Cilexetil USP Related Compound G
- Candesartan Cilexetil Impurity 7(Candesartan Cilexetil EP Impurity G)
- 3-((2'-(2H-Tetrazol-5-yl)biphenyl-4-yl)methyl)-2-ethoxy-3H-benzo[d]imidazole-4-carboxylic acid [CS-VII (Acid)
- Candesartan Impurity-G
- 1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid
- 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-Biphenyl]-4-yl)Methyl)-2-Ethoxy-1H-Benzo[d]iMidazole-7-Carboxylicacid
- Candesartan in methanol
- 139481-59-7
- C24H20N6O3
- Isotope
- Pharmaceutical raw material
