Oxacillin
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Oxacillin Eigenschaften
- Schmelzpunkt:
- 188 °C
- Siedepunkt:
- 686.8±55.0 °C(Predicted)
- Dichte
- 1.49±0.1 g/cm3(Predicted)
- pka
- pKa 2.72 (Uncertain)
- CAS Datenbank
- 66-79-5
Sicherheit
Oxacillin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Chemically this is 3-methyl-5-phenyl-4-isoxazolyl penicillin. It was synthesized in 1961 and has been extensively used in North America. It is available as an oral solution of 120 mg/5 ml. It usually comes in an injectable formulation of 1 and 2 g. A 10-g injectable formulation is also marketed.Indications
In terms of the spectrum of antimicrobial action, oxacillin is analogous to benzylpenicillin. However, it combines the resistance to penicillinase with durability in an acidic medium, which allows it to be used not only intramuscularly, but also orally. It is used for infections caused by penicillinase-producing staphylococci that are resistant to benzyl- and phenoxymethylpenicillins (septicemia, pneumonia, abscesses, empyemia, osteomyelitis, infected burns, infected wounds, and others). Synonyms of this drug are cryptocillin, liucipen, optocillin, totocillin, and others.Definition
ChEBI: A penicillin antibiotic carrying a 5-methyl-3-phenylisoxazole-4-carboxamide group at position 6.Antimicrobial activity
There is complete cross-resistance and tolerance with other group 3 penicillins. Oxacillin is frequently used to replace methicillin for standardized susceptibility testing to detect resistant staphylococci.Acquired resistance
In addition to methicillin-resistant strains producing the low affinity PBP 2a, rare methicillin-susceptible isolates of Staph. aureus display reduced susceptibility to oxacillin, due to incompletely defined chromosomal resistance mechanisms.Kontakt-Allergie
Oxacillin is a semisynthetic penicillin of the group M. It is closely related to cloxacillin.Clinical Use
Uses are those of group 3 penicillinsNebenwirkungen
There is cross-allergy with other penicillins and reactions are generally typical of the group. Abnormalities of liver function, especially elevation of transaminase levels, may occur, sometimes accompanied by fever, nausea, vomiting and eosinophilia. As with benzylpenicillin, neurotoxicity may develop on high dosage in patients with renal failure. Pseudomembranous colitis has been reported.Oxacillin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Chlor
Hydroxylamin
Thionyldichlorid
6-Aminopenicillansure
Ethylacetoacetat
Benzaldehyd
Natriumhydrogencarbonat
Downstream Produkte
Oxacillin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 31)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 7724 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 43340 | 58 |
TargetMol Chemicals Inc. | +8613564774135 |
zijue.cai@tsbiochem.com | United States | 19863 | 58 |
Beijing HuaMeiHuLiBiological Chemical | 010-56205725 |
waley188@sohu.com | China | 12335 | 58 |
Alta Scientific Co., Ltd. | 022-6537-8550 15522853686 |
sales@altasci.com.cn | China | 4511 | 55 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 |
info@efebio.com | China | 9806 | 58 |
ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 |
2853530910@QQ.com | China | 8014 | 62 |
Hubei Yangxin Medical Technology Co., Ltd. | 15374522761 |
3003392093@qq.com | China | 8369 | 55 |
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd. | 027-51831887 15337167856 |
hubeixinyuanshun@163.com | China | 10295 | 58 |
BOC Sciences | -- |
info@bocsci.com | USA | 0 | 65 |
66-79-5(Oxacillin)Verwandte Suche:
Cloxacillinnatrium
Cloxacillin
Oxacillin
Flucloxacillin
Dicloxacillin
Natrium-[2S-(2α,5α,6β)]-6-[[[3-(2-chlor-6-fluorphenyl)-5-methylisoxazol-4-yl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylat
Natrium-[2S-(2α,5α,6β)]-3,3-dimethyl-6-[[(5-methyl-3-phenylisoxazol-4-yl)carbonyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylat
4-Thia-1-azabicyclo[3.2.0]heptan-2-carbonsure, 6-[[[3-(2-Chlorphenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, [2S-(2α,5α,6β)]-, Verbindung mit N,N'-Bis(phenylmethyl)-1,2-ethandiamin (2:1)
- OXACILLIN
- [2S-(2,5,6)]-3,3-dimethyl-6-(methyl-3-phenylisoxaz-4-ole-carboxamide-7-oxy-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
- (2S,5R,6R)-3,3-Dimethyl-6-[(5-methyl-3-phenylisoxazol-4-yl)carbonylamino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
- Bactocil
- Oxazina
- Penstapho
- UWYHMGVUTGAWSP-JKIFEVAISA-N
- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-6-[[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino]-7-oxo-, (2S,5R,6R)-
- OXACILLIN USP/EP/BP
- Oxacillin D5Q: What is Oxacillin D5 Q: What is the CAS Number of Oxacillin D5 Q: What is the storage condition of Oxacillin D5 Q: What are the applications of Oxacillin D5
- OxacillinQ: What is Oxacillin Q: What is the CAS Number of Oxacillin
- Annamycin Impurity 100
- 66-79-5
- C19H19N3O5S
- C19H19N3O5S1