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Donepezil

Donepezil Struktur
120014-06-4
CAS-Nr.
120014-06-4
Englisch Name:
Donepezil
Synonyma:
5,6-Dimethoxy-2,3-dihydro-1H-inden-1-one;Donepenil;Donezepil;2-((1-Benzylpiperidin-4-yl)Methyl)-5,6-diMethoxy-2,3-dihydro-1H-inden-1-one;Donepezilo;N-Benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl] piperidine;2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-1h-inde;n-1-one;onepezil;HSDB7743
CBNumber:
CB0156314
Summenformel:
C24H29NO3
Molgewicht:
379.49
MOL-Datei:
120014-06-4.mol

Donepezil Eigenschaften

Schmelzpunkt:
207°C
Siedepunkt:
527.9±50.0 °C(Predicted)
Dichte
1.141±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
L?slichkeit
Acetone (Slightly), Chloroform (Slightly)
Aggregatzustand
Solid
pka
8.84±0.10(Predicted)
Farbe
White to Off-White
Wasserl?slichkeit
2.931 mg/L
CAS Datenbank
120014-06-4(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 26-36-36/37/39
RIDADR  UN 2811
HS Code  29333990
Giftige Stoffe Daten 120014-06-4(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Donepezil Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Donepezil is another “nonclassic,” centrally acting, reversible, noncompetitive AChEI that was approved in 1997 for treatment of mild-to-moderate AD and dementia. Its selectivity for AChE is 570- to 1,250-fold that for butyrylcholinesterase, and it also exhibits greater affinity for brain AChE than for AChE in the periphery.

Verwenden

Acetylcholine is a neurotransmitter involved in neural signaling throughout the body. Donepezil is a reversible acetylcholinesterase inhibitor that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine. It has a half-life in circulation of about 70 hours. As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system, donepezil is commonly used in the treatment of Alzheimer’s disease to improve cognition, memory, and behavior. In this way, it is intended to prevent or reverse dementia. Studies on these effects have been equivocal, indicating that more research into the therapeutic potential of donepezil is warranted.[Cayman Chemical]

Definition

ChEBI: Donepezil is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.

Allgemeine Beschreibung

Donepezil, (±)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one (Aricept), commonly referred to in the literature asE2020, is a reversible inhibitor of AChE. It is indicated forthe treatment of symptoms of mild-to-moderate Alzheimerdisease. Donepezil is approximately 96% bound to plasmaproteins, with an elimination half-life of 70 hours. It is metabolizedprincipally by the 2D6 and 3A4 isozymes of theP450 system.

Stoffwechsel

When compared to tacrine, donepezil exhibits greater CNS AChE selectivity, longer elimination half-life (70–104 hours in subjects older than 55 years) and little or no potential for hepatotoxicity. Donepezil is metabolized by CYP2D6 and CYP3A4 via demethylation, debenzylation, hydroxylation, oxidation to the cis-N-oxide, and glucuronidation. The 6-O-desmethyl metabolite accounts for 11% of a dose, and it exhibits AChE inhibitory activity comparable to that of the parent compound.

Donepezil Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Donepezil Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 377)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Anhui Dexinjia Biopharm Co., Ltd
+86-531-82375818 +8615064153060
sales01@jndxj.com China 291 58
Sinoway Industrial co., ltd.
0592-5800732; +8613806035118
xie@china-sinoway.com China 988 58
Hebei Dangtong Import and export Co LTD
+86-13910575315 +86-13910575315
admin@hbdangtong.com China 1000 58
Hangzhou Hyper Chemicals Limited
+86-0086-57187702781 +8613675893055
info@hyper-chem.com China 295 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 9087 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3009 60
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32957 60
Shanxi Naipu Import and Export Co.,Ltd
+86-13734021967 +8613734021967
kaia@neputrading.com China 1001 58

120014-06-4()Verwandte Suche:


  • DONEPEZIL
  • AKOS 226-23
  • n-1-one
  • 2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
  • 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL) METHYL] PIPERIDINE
  • 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride, hydrate(1:1:1)
  • Donepezil hydrochloride monohydrate
  • 2-[(1-Benzyl-4-piper
  • 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine
  • 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one
  • (2S)-2-[(1-benzylpiperidin-4-yl)Methyl]-5,6-diMethoxy-2,3-dihydro-1H-inden-1-one
  • Donepezil hydrochloride Monohydra
  • Donepezil HCl (Base)
  • Donepezil InterMediate
  • Donepezil, >=99%
  • Donepezil(2-((1-benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one)
  • Donepezil (as hydrochloride)
  • Aricept(Donepezil)
  • DONEPEZIL(E 2020)
  • (2R)-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-2,3-dihydroinden-1-one
  • 2-[(1-Benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
  • 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-
  • 2-[((1-benzyl-4-piperidyl) methyl] -5, 6-dimethoxy-2, 3-dihydroindene - 1-one
  • Donepezil USP/EP/BP
  • Donepezine
  • DonepezilQ: What is Donepezil Q: What is the CAS Number of Donepezil Q: What is the storage condition of Donepezil Q: What are the applications of Donepezil
  • 2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-1h-inde
  • N-Benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl] piperidine
  • 5,6-Dimethoxy-2,3-dihydro-1H-inden-1-one
  • Donezepil
  • 2-((1-Benzylpiperidin-4-yl)Methyl)-5,6-diMethoxy-2,3-dihydro-1H-inden-1-one
  • Donepenil
  • Donepezilo
  • 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindanon-2-yl)methyl]piperidine
  • onepezil
  • HSDB 7743
  • HSDB7743
  • HSDB-7743
  • 2-(1-Benzyl-piperidin-4-ylmethyl)-5,6-dimethoxy-indan-1-one
  • Asciminib Impurity 15
  • 120014-06-4
  • C24H28NO3
  • C23H38InNO2
  • Isotope
  • Other APIs
  • 120014-06-4
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