94841-17-5
中文名稱
鹽酸螺普利
CAS
94841-17-5
分子式
C22H30N2O5S2.HCl
分子量
503.07
MOL 文件
94841-17-5.mol
更新日期
2023/03/20 15:41:17
94841-17-5 結(jié)構(gòu)式
基本信息
中文別名
鹽酸螺普利 英文別名
RenpressRenormax
Sandopril
TI 211-950
Spirapril HCl
Unii-occ25lm897
Spirapril hydrochloride
(8S)-7-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic Acid Monohydrochloride
1,4-Dithia-7-azaspiro(4.4)nonane-8-carboxylic acid, 7-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-, monohydrochloride, (8S-(7(R*(R*)),8R*))-
常見問題列表
生物活性
Spirapril (SCH 33844) hydrochloride 是一種有效的血管緊張素轉(zhuǎn)換酶 (ACE) 抑制劑，具有降壓作用。Spirapril hydrochloride 競(jìng)爭(zhēng)性地與 ACE 結(jié)合，阻止血管緊張素I向血管緊張素 II 的轉(zhuǎn)化。Spirapril hydrochloride 是螺普利拉的一種口服活性前藥，可用于高血壓、充血性心力衰竭的研究。靶點(diǎn)
IC50: angiotensin converting enzyme
體內(nèi)研究
Spirapril (feeding needle; 10 mg/kg; 3 weeks) decreases alcohol intake in TGM123 mice and dose not reduce the alcohol consumption in TLM mice. Spirapril shows a 40.2% reduction in ACE activity in brain membrane from treated-mice. It crosses the blood-brain barrier and suppresses the transgene effect in the experiments.
| Animal Model: | TGM123 mice (expressing a rat angiotensinogen transgene) and TLM ( lacking the angiotensinogen gene) mice |
| Dosage: | 10 mg/kg |
| Administration: | Feeding needle; 10 mg/kg; 3 weeks |
| Result: | Alter voluntary alcohol consumption in animals. Crossed the blood-brain barrier and may influences alcohol consumption mainly by decreasing central angiotensin II (AII) levels. |