947914-18-3
中文名稱
ML-365
英文名稱
ML365
CAS
947914-18-3
分子式
C22H20N2O3
分子量
360.41
MOL 文件
947914-18-3.mol
更新日期
2024/10/28 15:27:06
947914-18-3 結(jié)構(gòu)式
基本信息
中文別名
化合物ML365KCNK3小分子抑制劑(ML365)
英文別名
ML365CS-2437
ML-365
ML365
ML 365
2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide
2-methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamide
Benzamide, 2-methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]-
所屬類別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)429.9±40.0 °C(Predicted)
密度1.253±0.06 g/cm3(Predicted)
儲(chǔ)存條件2-8°C
儲(chǔ)存條件Sealed in dry,2-8°C
溶解度DMSO:72.0(Max Conc. mg/mL);199.77(Max Conc. mM)
Ethanol:18.0(Max Conc. mg/mL);49.94(Max Conc. mM)
Ethanol:18.0(Max Conc. mg/mL);49.94(Max Conc. mM)
酸度系數(shù)(pKa)13.21±0.70(Predicted)
形態(tài)粉末
顏色White to off-white
ML-365價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/08/19 | HY-12345 | ML-365 ML365 | 947914-18-3 | 5mg | 750元 |
| 2024/08/19 | HY-12345 | ML-365 ML365 | 947914-18-3 | 10mM * 1mLin DMSO | 830元 |
| 2024/08/19 | HY-12345 | ML-365 ML365 | 947914-18-3 | 10mg | 1150元 |
常見(jiàn)問(wèn)題列表
生物活性
ML365是一種新型的TASK1或KCNK3小分子抑制劑。靶點(diǎn)
| Target | Value |
|
TASK1/KCNK3
() |
體外研究
ML365 blocks TASK1 channels in both the thallium influx fluorescent assay (IC
50
= 4 nM) and an automated electrophysiology assay (IC
50
= 16 nM).
ML365 displays little or no inhibition at 30 μM of more distantly related potassium channels, Kir2.1, potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2), and human ether-a go-go-related gene (hERG).
ML365 does not exhibit acute toxicity in cell-based assays at concentrations up to 30 μM.