85643-19-2
中文名稱
仙茅苷
英文名稱
CURCULIGOSIDE
CAS
85643-19-2
分子式
C22H26O11
分子量
466.44
MOL 文件
85643-19-2.mol
更新日期
2024/12/23 13:12:25
85643-19-2 結(jié)構(gòu)式
基本信息
中文別名
仙茅甙仙茅苷
仙茅苷(標(biāo)準(zhǔn)品)
仙茅苷(仙茅甙)
仙茅苷, 來源于仙茅
CURCULIGOSIDE 仙茅苷
英文別名
CURCULIGOSIDECurculigosideA
Curculigoside, 98%, from Curculigo orchioides Gaertn.
β-D-Glucopyranoside,2-[[(2,6-diMethoxybenzoyl)oxy]Methyl]-4-hydroxyphenyl
β-D-Glucopyranoside, 2-[[(2,6-dimethoxybenzoyl)oxy]methyl]-4-hydroxyphenyl
2-[[(2,6-Dimethoxybenzoyl)oxy]methyl]-4-hydroxyphenyl beta-D-Glucopyranoside
[5-Hydroxy-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]methyl-2,6-dimethoxybenzoate
物理化學(xué)性質(zhì)
外觀性狀白色顆粒結(jié)晶，易溶于甲醇，幾乎不溶于乙醚，來源于仙茅。
熔點158-160 °C(Solv: methanol (67-56-1))
沸點734.9±60.0 °C(Predicted)
密度1.450±0.06 g/cm3(Predicted)
儲存條件-20°C冷凍
溶解度少許溶于甲醇
酸度系數(shù)(pKa)9.70±0.20(Predicted)
形態(tài)固體
顏色米白色
常見問題列表
概述
仙茅苷有補腎壯陽、益精血、強健筋骨、行血消腫的功效。用于腎虛不足、陽痊遺精、虛瘦內(nèi)傷、腰脊冷痛、寒虛冷瀉、帶下、小便頻數(shù)等臨床病癥。生物活性
Curculigoside 是 C. orchioide 中的主要皂苷，具有顯著的抗氧化，抗骨質(zhì)疏松，抗抑郁和神經(jīng)保護作用。
通過調(diào)節(jié) JAK/STAT/NF-κB 信號傳導(dǎo)途徑，在體內(nèi)和體外表現(xiàn)出顯著的抗關(guān)節(jié)炎作用。靶點
JAK; STAT; NF-κB
體外研究
Curculigoside (1-64 μg/ml; 72 hours) exerts significant inhibitory effects on MH7A cell viability between 1 and 64 μg/ml in MH7A cells. Curculigoside (4-16 μg/ml; 24 hours) decreases the protein expression of JAK1, JAK3 and STAT3 compared to the TNF-α group.
Cell Viability Assay
| Cell Line: | MH7A cells |
| Concentration: | 1 μg/ml; 2 μg/ml; 4 μg/ml; 8 μg/ml; 16 μg/ml; 32 μg/ml; 64 μg/ml |
| Incubation Time: | 72 hours |
| Result: | Had inhibitory effect on MH7A cells. |
Western Blot Analysis
| Cell Line: | MH7A cells |
| Concentration: | 4 μg/ml; 64 μg/ml |
| Incubation Time: | 24 hours |
| Result: | Downregulated JAK1, JAK3 and STAT3 protein expression. |