18296-44-1
中文名稱
戊曲酯
英文名稱
Valtrate
CAS
18296-44-1
分子式
C22H30O8
分子量
422.47
MOL 文件
18296-44-1.mol
更新日期
2024/12/20 18:42:33
18296-44-1 結(jié)構(gòu)式
基本信息
中文別名
戊曲酯環(huán)氧戊喃
纈草三酯
戊曲酯標(biāo)準(zhǔn)品
戊曲酯對(duì)照品
戊曲酯/纈草素
纈草三酯(纈草素
戊曲酯,纈草三酯
纈草三酯(液體)
纈草素、環(huán)氧戊喃、戊曲酯
英文別名
ValtrateValtratuM
VALTRATE(P)
ValepotriatuM
HalazuchroMe B
Valtrate USP/EP/BP
VALTRATE(P)(PLEASE CALL)
(1S,7R)-4-Acetoxymethyl-6,7aα-dihydrospiro[cyclopenta[c]pyran-7(1H),2'-oxirane]-1α,6α-diol 1,6-bis(3-methylbutanoate)
[(1S,6S,7aS)-4-(Acetyloxymethyl)-1-(3-methylbutanoyloxy)spiro[6,7a-dihydro-1H-cyclopenta[c]pyran-7,2'-oxirane]-6-yl] 3-methylbutanoate
Butanoic acid, 3-methyl-, 1,1'-[(1S,2'R,6S,7aS)-4-[(acetyloxy)methyl]-6,7a-dihydrospiro[cyclopenta[c]pyran-7(1H),2'-oxirane]-1,6-diyl] ester
所屬類別
生物化工：中草藥成分物理化學(xué)性質(zhì)
外觀性狀黃色液體，可溶于甲醇、乙醇、DMSO等有機(jī)溶劑，來(lái)源于蛛蛛香，纈草。
沸點(diǎn)525.9±50.0 °C(Predicted)
密度1.22±0.1 g/cm3(Predicted)
儲(chǔ)存條件Refrigerator
溶解度可溶于氯仿（輕微，超聲處理），甲醇（輕微）
形態(tài)Oil
顏色淺棕色至深黃色
水溶解性微溶于水
常見(jiàn)問(wèn)題列表
生物活性
Valepotriate, 從 Valeriana jatamansi 分離而來(lái)，具有抗癲癇和抗癌活性。體內(nèi)研究
Valepotriate?showed significant anti-epileptic activity against MES- and PTZ-induced epilepsy at doses of 5, 10, and 20 mg/kg, and ED50?values for MES- and PTZ-induced epilepsy were 7.84 and 7.19 mg/kg, respectively. Furthermore,?valepotriate?(10 and 20 mg/kg) can significantly prolong sleeping time and shorten the latency time on the pentobarbital sodium-induced sleeping time test. Furthermore,?valepotriate?(5, 10, and 20 mg/kg) could significantly up-regulate the expression of GABAA, GAD65, and Bcl-2 and down-regulate the expression of caspase-3, but had no significant effect on the expression of GABAB.