| Identification | Back Directory | [Name]
Valtrate | [CAS]
18296-44-1 | [Synonyms]
Valtrate
ValtratuM
VALTRATE(P)
ValepotriatuM
HalazuchroMe B
Valtrate USP/EP/BP
VALTRATE(P)(PLEASE CALL)
(1S,7R)-4-Acetoxymethyl-6,7aα-dihydrospiro[cyclopenta[c]pyran-7(1H),2'-oxirane]-1α,6α-diol 1,6-bis(3-methylbutanoate)
[(1S,6S,7aS)-4-(Acetyloxymethyl)-1-(3-methylbutanoyloxy)spiro[6,7a-dihydro-1H-cyclopenta[c]pyran-7,2'-oxirane]-6-yl] 3-methylbutanoate
Butanoic acid, 3-methyl-, 1,1'-[(1S,2'R,6S,7aS)-4-[(acetyloxy)methyl]-6,7a-dihydrospiro[cyclopenta[c]pyran-7(1H),2'-oxirane]-1,6-diyl] ester | [EINECS(EC#)]
242-174-2 | [Molecular Formula]
C22H30O8 | [MDL Number]
MFCD00868024 | [MOL File]
18296-44-1.mol | [Molecular Weight]
422.47 |
| Chemical Properties | Back Directory | [Boiling point ]
525.9±50.0 °C(Predicted) | [density ]
1.22±0.1 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly, Sonicated), Methanol (Slightly) | [form ]
Oil | [color ]
Pale Brown to Dark Yellow | [Water Solubility ]
slightly soluble in water |
| Hazard Information | Back Directory | [Uses]
Valtrate is a Rev-transport inhibitor with anti-HIV activity from Valerianae Radix. | [Definition]
ChEBI: Valtratum is a fatty acid ester. | [in vivo]
Valepotriate?showed significant anti-epileptic activity against MES- and PTZ-induced epilepsy at doses of 5, 10, and 20 mg/kg, and ED50?values for MES- and PTZ-induced epilepsy were 7.84 and 7.19 mg/kg, respectively. Furthermore,?valepotriate?(10 and 20 mg/kg) can significantly prolong sleeping time and shorten the latency time on the pentobarbital sodium-induced sleeping time test. Furthermore,?valepotriate?(5, 10, and 20 mg/kg) could significantly up-regulate the expression of GABAA, GAD65, and Bcl-2 and down-regulate the expression of caspase-3, but had no significant effect on the expression of GABAB[2]. | [storage]
-20°C, protect from light |
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