77603-42-0
77603-42-0 結(jié)構(gòu)式
基本信息
8-硝基吲哚并[2,1-B]喹唑啉-6,12-二酮
8-Nitrotryptanthrin
GNF-PF-3777 (8-Nitrotryptanthrin)
Indolo[2,1-b]quinazoline-6,12-dione, 8-nitro-
物理化學(xué)性質(zhì)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/08/19 | HY-100687 | 8-NITROTRYPTANTHRIN GNF-PF-3777 | 77603-42-0 | 1mg | 900元 |
| 2024/08/19 | HY-100687 | 8-NITROTRYPTANTHRIN GNF-PF-3777 | 77603-42-0 | 5mg | 2160元 |
| 2024/08/19 | HY-100687 | 8-NITROTRYPTANTHRIN GNF-PF-3777 | 77603-42-0 | 10mM * 1mLin DMSO | 2900元 |
常見問題列表
|
rhIDO2 1.8 μM (IC 50 ) |
rhIDO2 0.97 μM (Ki) |
The typtanthrin derivative GNF-PF-3777 (8-Nitrotryptanthrin; Compound 5i) is found to be a potent hIDO2 inhibitor with superior efficiency far better than that of the most frequently-used inhibitor L-1-MT. The IC 50 values show that all nine tryptanthrin compounds display hIDO2 inhibitory activities, GNF-PF-3777 demonstrates much stronger inhibition (1.87 μM) than both L-1-MT (82.53 μM) and D-1-MT (262.75 μM). GNF-PF-3777 exhibits significant antitrypanosomal activity with EC 50 of 0.82 μM. GNF-PF-3777 (8-Nitrotryptanthrin) has a microplate Alamar Blue assay (MABA) minimum inhibitory concentration (MIC) value of 0.032 μg/mL. GNF-PF-3777 also has a LORA MIC value of 2.4 μg/mL, while the majority of analogues lack LORA activity.